Clinical trials: Early Interventions
HIV
Efficacy of SMS to Improve Early Retention in HIV Care for PLWH in Lima
Randomized controlled study that will evaluate the effect of a text message-based strategy to improve retention in HIV care.
- Trial name
- NCT03862196
- Testing
- Tailored text messages to improve retention in HIV care
- Where
- Peru
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- NGO Via Libre
Infant Behavior, Child Behavior
Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics
This study tests a comprehensive approach to the promotion of school readiness in low-income families, beginning shortly after the birth of the child, through enhancement of positive parenting practices (and when present…
- Conditions
- Infant Behavior, Child Behavior, Parenting, Child Rearing
- Trial name
- NCT02459327
- Testing
- Video Interaction Project, Family Check Up
- Where
- 2 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- New York University
Child Maltreatment
Evaluation of a 2-session Parent Training Programme for Caregivers of Younger Children in Zimbabwe
A pilot, exploratory cluster Randomised Controlled Trial (RCT) with two arms will be conducted to test a two-session parent training programme for caregivers of children enrolled in early childhood development classes in Harare…
- Trial name
- NCT06431321
- Testing
- Tabudira Parenting Intervention for Early Childhood Development, Nutritional guide for younger children
- Where
- Zimbabwe
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Type 2 Diabetes, Subjective Cognitive Decline
China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society.
- Conditions
- Type 2 Diabetes, Subjective Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06650969
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Child Development, Father-Child Relations
A Quasi-experimental Evaluation of the Malezi Program in Tanzania
The quality of caregiving and the parent-child relationship is critical for early child development (ECD) and has been shown to be modifiable.
- Conditions
- Child Development, Father-Child Relations, Knowledge, Attitudes, Practice, Safety Issues
- Trial name
- Malezi II (NCT05244161)
- Testing
- RMV-ECD
- Where
- Tanzania
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Cardiovascular Risk Factor
Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity
Our goal is to develop personalized decision rules for selecting the frequency, timing, and content of messages to promote physical activity.
- Trial name
- RandomAIM (NCT03907683)
- Testing
- Short Message with Text and Optional Image
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Penn State University
Myopia
Early Intervention for High Risk Premyopic Children
The purpose of this research project is to add evidence of pharmacological (0.025% atropine) and optical (Defocus Integrated Multiple Segments Triple Enhanced Design spectacle lenses ) approaches for myopia prevention among…
- Trial name
- NCT07863713
- Testing
- 0.025% atropine eye drops, DIMS TED
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Achievement
The Positive Family Support Project - Partnering With Families for a Successful Transition to School
The Positive Family Support Project seeks to understand some of the factors that increase success for children in early elementary school, such as positive family support at home.
- Trial name
- NCT02289092
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Psychosis, Schizophrenia and Related Disorders
Community Reinforcement Approach and Family Training for Substance Use in Early Psychosis Intervention
The goal of this pilot feasibility and proof of concept study is to evaluate whether Community Reinforcement and Family Training (CRAFT) as adapted for group delivery in an early psychosis intervention (EPI) program has a…
- Conditions
- Psychosis, Schizophrenia and Related Disorders, Schizophrenia Spectrum and Other Psychotic Disorders, Substance Use
- Trial name
- CRAFT-EPI (NCT05300633)
- Testing
- Group-Based Community Reinforcement Approach and Family Training-Early Psychosis Intervention (CRAFT-EPI)
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Child Development
KeySteps@JC Phase One Follow-up Study
This proposed study is a 5-year follow-up study of "KeySteps Phase One Study", which focused on bridging the gap between students from privileged and underprivileged families.
- Trial name
- NCT05778669
- Testing
- Monitoring of medical, health and psychosocial conditions
- Where
- Hong Kong
- Volunteers
- 1,486 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Endovascular Therapy, Neurological Complications
Nurse-Led Predictive Protocol Cuts Neuro-Endovascular Complications
The goal of this prospective cohort study was to develop and test a 12-item, nurse-led predictive checklist that can quickly identify patients at high risk for neurological complications (bleeding, re-blockage, brain swelling…
- Trial name
- NCT07304973
- Testing
- predictive checklist
- Where
- China
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Smoking, Health Behavior
Early Detection of and Intervention Towards Chronic Diseases Among Individuals Without Formal Education
In this randomized controlled study it is investigated if a proactive action by the general practitioner offering individuals without formal education a preventive health check will lead to a larger number of diagnoses in form of…
- Conditions
- Smoking, Health Behavior, Chronic Disease
- Trial name
- NCT01979107
- Testing
- Proactive action by the general practitioner
- Where
- Denmark
- Volunteers
- 1,104 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Autism Spectrum Disorder
Tailoring Treatment Targets for Early Autism Intervention in Africa
Naturalistic Developmental Behavioral Interventions (NDBIs), an evidence-based early autism spectrum disorder (ASD) intervention approach, target key behaviors that help language development.
- Trial name
- NCT04068688
- Testing
- Early Start Denver Model (ESDM), Telehealth coaching
- Where
- South Africa
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Duke University
Delirium
Haloperidol Prophylaxis in Older Emergency Department Patients
The investigators propose a multicenter, randomized, double-blinded, placebo-controlled trial to study the effect of additive low-dose haloperidol prophylaxis on top of exciting care in a general population of older patients (age…
- Trial name
- HARPOON (NCT01530308)
- Testing
- Haloperidol
- Where
- 6 sites in Netherlands
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Dementia
Two Interventions for Early Stage Dementia: A Comparative Efficacy Trial
Alzheimer's disease (AD) is increasing exponentially, with a projected quadrupling of cases by the mid 21st century. Individuals with AD are at increased risk for a host of medical and psychiatric conditions, and evidence is…
- Trial name
- NCT01550718
- Testing
- ESML-EX (Physical Activity Program), ESML-Social (Social Activity Program)
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Washington
School Readiness, School Environment
Every Newborn Reach Up Early Education Intervention for All Children Education (ENREACH) Education
The goal of the project is to assess the scale-up of the program, focusing on improving school readiness among preschool children, enhancing capacity building for parents and teachers, and utilizing a cluster randomized…
- Trial name
- ENREACH-ED (NCT06890156)
- Testing
- ENREACH child-parent-teacher triad
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Infant Sleep Problem
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
Over the last 40 years, obesity has increased dramatically among all age groups, especially in infants and young children, and became an important global public health challenge, thus early prevention is the highest priority.
- Trial name
- NCT05159141
- Testing
- Behavioral sleep intervention
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Post-Traumatic Osteoarthritis of Knee
Early Regenerative Intervention for Post-Traumatic Osteoarthritis
The goal of the proposed research is to compare the ERIPTO protocol for post-traumatic osteoarthritis of the knee with that of bone marrow aspirate concentrate (BMAC) only.
- Trial name
- ERIPTO (NCT04222140)
- Testing
- ERIPTO Protocol, BMAC Only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Affinity Health Research Institute
Obesity
Prevention of Childhood Obesity
This study is conducting preliminary testing to find out whether a particular educational program can alter parental overcontrol of their children's eating.
- Trial name
- NCT00788203
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Stanford University