Clinical trials: Early Osteoarthritis
Osteoarthritis, Knee
Mobile Technology to Measure Knee Health in Osteoarthritis
Veterans face a high prevalence of knee osteoarthritis (OA), but current diagnostic methods often miss early stages when interventions are more effective.
- Trial name
- NCT07580222
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
a Single Intraarticular Injection of PRP for Early Knee OA
This study aimed to investigate the efficacy of a single intraarticular injection of PRP for the treatment of early knee OA.
- Trial name
- NCT04027738
- Testing
- PRP
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis, Knee
Early Surgical Effects and Influencing Factors of High Tibial Osteotomy in the Treatment of Knee Osteoarthritis
Exploring the factors influencing postoperative functional recovery after high tibial osteotomy
- Trial name
- NCT06512948
- Testing
- High tibial osteotomy
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Shufeng Li
Osteoarthritis, Knee, Meniscus; Degeneration
Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: KNEE-DEeP Study
Knee pain due to a degenerative meniscal tear (DMT) or early osteoarthritis (OA) is a frequent presentation in middle-aged and older adults.
- Trial name
- KNEE-DEeP (NCT06576557)
- Testing
- KNEE-DEeP intervention- Knowledge translation and exercise for early degenerative knee pain
- Where
- Ireland
- Volunteers
- 36 people
- Sponsor
- University of Limerick
Insulin Resistance, Postoperative Complication
Evaluation of Preoperative Oral Rehydration Solution in Colectomy
Elective colectomy procedures typically require bowel preparation starting 2 days prior to the surgery. Osmotic laxatives such as Colyte® are administered 2 days prior, and Nothing by mouth (NPO) is required 1 day prior to ensure…
- Trial name
- NCT02062788
- Testing
- Oral rehydration solution
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Coxarthrosis
Measurement of Early Bone Loss Around a Total Hip Arthroplasty
Research with DXA has shown the pattern of bone remodelling around an implant. The baseline and reference value for such calculations is the first measurement after the operation.
- Trial name
- DXACorail (NCT01046019)
- Volunteers
- 23 people
- Sponsor
- Ullevaal University Hospital
Osteoarthritis, Hip
H-29 DELTA Multihole TT Study.
This study is aimed to provide a clinical and radiographic evaluation of 50 suitable subjects who underwent a complex primary or a revision Total Hip Arthroplasties with DELTA Multihole TT acetabular cup in 2019 onwards.
- Trial name
- NCT05007067
- Testing
- DELTA Multihole TT
- Where
- Poland
- Volunteers
- 7 people
- Sponsor
- Limacorporate S.p.a
Unilateral Primary Osteoarthritis of Hip
Comparing the Clinical Effects of Posterior Approach Versus Lateral Approach in Osteoarthritis Patients With a THA
The aim of this study is to investigate the clinical outcome of the two different, but widely used, surgical approaches (Posterior approach and Lateral approach) of primary total hip arthroplasty in patients diagnosed with…
- Trial name
- COMPALA (NCT01616667)
- Testing
- Total hip arthroplasty
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Total Knee Arthroplasty Recovery, Total Knee Replacement
Telerehabilitation Versus Clinic-Based Rehabilitation for Functional Recovery Following Primary Total Knee Arthroplasty
The goal of this clinical trial is to determine if rehabilitation delivered by telehealth works as well as rehabilitation delivered in person at a clinic, for people recovering from total knee replacement surgery.
- Conditions
- Total Knee Arthroplasty Recovery, Total Knee Replacement, Total Knee Arthroplasty\(TKA\), Knee Arthritis Osteoarthritis
- Trial name
- NCT07834229
- Testing
- Rehabilitation treatment sessions focussing on education and exercise prescription.
- Where
- Australia
- Volunteers
- 108 people
- Sponsor
- The University of Western Australia
Knee Osteoarthritis (Knee OA), Total Knee Arthroplasty
Early Clinical Benefits of Robot-Assisted vs Manual Total Knee Arthroplasty (RATKA-EARLY)
This study, called the RATKA-EARLY trial, was designed to compare two surgical techniques used in total knee replacement (also known as total knee arthroplasty or TKA).
- Trial name
- RATKA-EARLY (NCT07078149)
- Testing
- Robotic-assisted TKA (RATKA)., Conventional manual TKA (mTKA)
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitario Santa Cristina
Meniscus Tear
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears.
- Trial name
- NCT06532851
- Testing
- Progressive Resistance Exercise (PRE), Aerobic Exercise, Control
- Where
- 2 sites in Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Ankle Osteoarthritis, Ankle - Recurrent Dislocation
Early MOtion Total Ankle Artroplasty
Evaluate the clinical and radiographic results of patients undergoing total ankle arthroplasty and treated in the post-operative period in a randomized manner with early mobilization of the ankle joint or with cast immobilization…
- Conditions
- Ankle Osteoarthritis, Ankle - Recurrent Dislocation, Cartilage Disease, Ankle Arthropathy
- Trial name
- EMOTAA (NCT06525545)
- Testing
- early mobilizzation of the ankle
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthrosis
Early Stability of the Delta-TT Cup With Polyethylene Insert Versus a Ceramic Insert. A RSA Study.
The goal of this study is to study the stability of the Delta-TT cup with polyethylene insert and the Delta-TT cup with ceramic insert both combined with the H-MAX femoral stem by means of RSA to assess whether the differences in…
- Trial name
- RSA-DELTA-TT (NCT03093038)
- Testing
- H-MAX stem & Delta-TT cup + polyethylene, H-MAX stem & Delta-TT cup + ceramic, C2 stem & Delta-TT cup + ceramic
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- JointResearch
Knee Osteoarthritis
Early Outcomes of MAKO Medial Unicompartmental Knee Arthroplasty
To determine if robotically-assisted UKA results in more consistent and improved component positioning and better patient reported outcome scores compared to manual TKA and MAKO TKA.
- Trial name
- NCT05736601
- Testing
- focus motion knee brace
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Washington University School of Medicine
Treatment Complication
Autologous Bone Marrow Aspirate Concentrate Injection for the Treatment of Early Osteoarthritis:Baghdad 2022
We present a randomized controlled trial (RCT) to assess the efficacy of autologous bone marrow aspirate concentrate BMAC of 1.8x 10 9 median cellular content in the treatment of early symptomatic knee OA.
- Trial name
- NCT05193877
- Testing
- autologous bone marrow aspirate concentrate by centrifugation
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Global Stem Cell Center, Baghdad
Knee Arthritis, Osteoarthritis
A Single-Center Phase 1 Study of ceAF for Knee Osteoarthritis (KOA)
Approximately 25 participants aged 18-70 years, with knee pain rated 4-7 on a 10-point visual analogue scale (VAS) and a disease duration of 6 months to 10 years, will be enrolled. The study has two parts.
- Trial name
- KOA (NCT07902128)
- Testing
- Animal early embryo extract
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Knee Chondropathy, Osteoarthritis, Knee
Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
The investigators hypothesized that intra-articular injections of Platelet-rich Plasma (PRP) to treat knee degenerative articular cartilage pathology could determine pain relief and recovery of knee function with overall clinical…
- Trial name
- PRP2009 (NCT01670578)
- Testing
- PRP, Hyaluronic acid
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
Effects of Bandaging and Kinesiotaping® in Patients With Total Knee Arthroplasty
The study aimed to compare the effectiveness of elastic bandaging, Kinesio taping, and short stretch bandaging techniques on postoperative pain, edema, and functional level in the early stage after total knee arthroplasty.
- Trial name
- NCT05847725
- Testing
- Elastic bandaging, Short stretch bandaging, Kinesio taping
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Early Osteoarthritis
Clinical and Molecular Aspects of Early Osteoarthritis
The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis.
- Trial name
- NCT04267510
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Montpellier