Clinical trials: Edema, Pulmonary
Acute Heart Failure
Early and Comprehensive Care Bundle in Elderly for Acute Heart Failure: a Stepped Wedge Cluster Randomized Trial
This is a prospective multicentre (N=15), stepped-wedge randomized trial that aims to evaluate the benefit of a protocolised comprehensive care bundle for early management of acute heart failure in the ED.
- Trial name
- ELISABETH (NCT03683212)
- Testing
- Early intensive care bundle
- Where
- France
- Volunteers
- 503 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transfusion-associated Circulatory Overload, Blood Transfusion Reaction
TACO Crossover TRIAL
This is an open-label, prospective crossover randomized controlled trial to investigate wether TACO is solely hydrostatic pressure overload or arises from a combination of hydrostatic pressure overload and capillary leakage, by…
- Trial name
- NCT03135457
- Testing
- Autologous RBC transfusion, Saline transfusion
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
High Altitude Pulmonary Hypertension, Sleep Apnea
Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT03165019
- Where
- Kyrgyzstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Hypertension, Oxygen Therapy
Effect of Oxygen Therapy for Patients With Precapillary Pulmonary Hypertension Who Experience an Altitude Related Adverse Health Effect (ARAHE) During 30h Exposure to 2500m
To study whether oxygen therapy titrated to maintain oxygenation (SpO2) > 90% at 2500m would resolve altitude-related adverse health effects, symptoms and impaired exercise during 30h exposure to high altitude.
- Trial name
- NCT05112172
- Testing
- Oxygen Therapy
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
High Altitude Pulmonary Hypertension
Altitude Related Adverse Health Effects (ARAHE) in Patients With Precapillary Pulmonary Hypertension During 30h Exposure to 2500m
The interest of journeys to high altitude regions for recreational or professional purposes is increasing, also among potentially vulnerable groups including patients with chronic cardiopulmonary diseases such as pulmonary…
- Trial name
- NCT05107700
- Testing
- Stay at altitude 2500 m above sea level (high altitude), Stay at altitude 470 m above sea level (low altitude)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Pneumonia, Pulmonary Edema
Chest U/S in Differentiating Lung Congestion & Pneumonia in Adult Critically-ill Patients and Its Prognostic Impact
This study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion .
- Trial name
- NCT05636631
- Testing
- Chest ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Neurogenic Lung Edema
Rule of Carbone Monoxyde in the Ex Vivo Lung Perfusion Reconditionning
Ex vivo lung perfusion (EVLP) is not a new concept and has been widely used to study lung function in small animals. It also has been shown to be a useful technique to evaluate lungs from donation after cardiac death (DCD)…
- Trial name
- NCT02032082
- Testing
- Carbone monoxide
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital of Mont-Godinne
Congenital Cystic Adenomatoid Malformation
Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
Congenital cystic adenomatoid malformations (CCAMs) are theorized to be growing immature lung tissue. Administration of maternal steroids in the mid-trimester may stop the growth or decrease the size of the CCAM, thus increasing…
- Trial name
- CCAM Steroids (NCT00670956)
- Testing
- Betamethasone
- Where
- 3 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Weaning Failure, Weaning-induced Pulmonary Edema
Incidence and Risk Factors of Weaning-induced Cardiac Dysfunction: Results From a Multicenter, Observational Study
During weaning from mechanical ventilation, the shift from positive to negative pressure ventilation may be responsible for a cardiac dysfunction that can lead to the development of pulmonary oedema (weaning-induced pulmonary…
- Conditions
- Weaning Failure, Weaning-induced Pulmonary Edema, Spontaneous Breathing Trial
- Trial name
- WIPO (NCT05318261)
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
Pneumonia, Coronavirus Infection in 2019 (COVID-19)
Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19
This phase I/II trial studies low-dose radiation therapy as a focal anti-inflammatory treatment for patients with pneumonia or SARS associated with COVID-19 infection.
- Conditions
- Pneumonia, Coronavirus Infection in 2019 (COVID-19), Severe Acute Respiratory Syndrome (SARS) Pneumonia
- Trial name
- RESCUE 1-19 (NCT04366791)
- Testing
- Low Dose Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Emory University
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
PEP-device for Treatment of Swimming-induced Pulmonary Edema (SIPE)
In swimming induced pulmonary edema (SIPE), there is a lack of knowledge regarding optimal treatment. The present study was designed to assess the benefit of treatment with positive expiratory pressure device (PEP-device)…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases
- Trial name
- NCT05227222
- Testing
- PEP-device
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Dalarna County Council, Sweden
Fluid Volume Excess
Lung Ultrasound Versus Cardiometry in Detection of Extravascular Lung Water in Pediatric Patients on Hemodialysis.
Comparing the efficacy of both lung ultrasound and electrical cardiometry to detect the extravascular lung water and volume status in pediatric patients on regular hemodialysis and use them as non-invasive methods for early…
- Trial name
- NCT05943717
- Testing
- lung ultrasound and electrical cardiometry
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
High Altitude Pulmonary Hypertension
The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of theophylline and bambuterol in healthy human…
- Trial name
- NCT01566565
- Testing
- Theophylline and Bambuterol
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Norwegian Armed Forces Medical Service
Contrast Induced Nephropathy
Preventing Contrast Nephropathy With Sodium Bicarbonate in Patients With Pulmonary Edema,Heart Failure,Uncontrolled HTN
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents.
- Trial name
- NCT00513825
- Testing
- Sodium Bicarbonate
- Where
- Iran
- Volunteers
- 72 people
- Sponsor
- Tehran University of Medical Sciences
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS)
In swimming induced pulmonary edema (SIPE), there is a lack of knowledge regarding optimal treatment. The present study was designed to assess the benefit of continuous positive airway pressure (CPAP) compared to oxygen as a…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases
- Trial name
- OCTOPUS (NCT04307615)
- Testing
- Oxygen + continuous positive airway pressure (CPAP), Oxygen
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Dalarna County Council, Sweden
Heart Failure
Mechanically Optimizing Cardiac Preload in Heart Failure Patients
The purpose of the current study is to determine if partial balloon occlusion of the inferior vena cava can optimize cardiac pre-load and subsequently pulmonary pressures and cardiac output as a novel method to unload pulmonary…
- Trial name
- NCT04338503
- Testing
- Partial IVC occlusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cardioflow Technologies, LLC
Dyspnea, Paroxysmal, Heart Failure, Left Sided
Management of Cardiogenic Pulmonary Edema (RENAU-OAP)
The prevalence of heart failure is estimated to 2.3 percent of the adult population and strongly increases with age, according to french disability-health surveys.
- Trial name
- RENAU-OAP (NCT03148847)
- Testing
- Baseline care, Referential's dissemination
- Where
- France
- Volunteers
- 859 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Weaning-induced Pulmonary Edema
Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema
Weaning-induced pulmonary edema (WIPE) from the ventilator is a frequent cause of extubation failure or delay, which prolongs the duration of invasive mechanical ventilation and the associated morbidity and mortality.
- Trial name
- WAPITI 2 (NCT07666880)
- Testing
- T-piece SBT, PS-ZEEP SBT
- Where
- 4 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Limoges
Covid19
Chest Radiography in COVID-19 Patients
To assess the prognostic performance of the RALE score with respect to duration of ventilation, and to describe changes in the RALE score over time.
- Trial name
- NCT04485338
- Where
- Netherlands
- Volunteers
- 139 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)