Clinical trials: Effect Increased
Risk Reduction, Breast Cancer
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens
Women at risk for development of breast cancer and experiencing vasomotor menopausal symptoms (hot flashes) will be randomized to bazedoxifene (BZA) plus conjugated estrogens (CE) for 6 months versus a wait list control.
- Trial name
- NCT04821141
- Testing
- Bazedoxifene and Conjugated Estrogens
- Where
- 6 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Melanoma
STA-4783/Paclitaxel or Paclitaxel Alone in Melanoma
This study is designed to assess the efficacy of a weekly treatment regimen of STA-4783 and paclitaxel in comparison to paclitaxel alone on tumor response in metastatic melanoma patients.
- Trial name
- NCT00084214
- Testing
- STA-4783, Paclitaxel
- Where
- 28 sites in United States
- Volunteers
- 103 people
- Sponsor
- Synta Pharmaceuticals Corp.
Polycystic Ovary Syndrome
Long Term Metformin in Women With Polycystic Ovary Syndrome
The investigators analyzed collection data of 10 years for the efficacy of metformin on body mass, menstrual frequencies, metabolic and hormonal outcomes in women with polycystic ovary syndrome (PCOS) and BMI ≥ 25kg/m2.
- Trial name
- NCT04043221
- Where
- Slovenia
- Volunteers
- 180 people
- Sponsor
- University Medical Centre Ljubljana
Overweight, Obesity
The Beneficial Effects of a Protein-rich Breakfast on Appetite Control & Cognition in Overweight and Obese Adolescents
The purpose of this study is to assess whether the daily addition of a protein-rich breakfast leads to beneficial changes in appetite control, food intake regulation,and cognitive function in overweight \& obese 'breakfast…
- Trial name
- NCT01192100
- Testing
- Breakfast Skipping, Normal Protein Breakfast Meals, Protein-rich Breakfast Meals
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Gastroesophageal Disease
To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure
The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.
- Trial name
- IRUSESOM0428 (NCT01093339)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Southern Arizona VA Health Care System
Aggression, Stress
The Therapeutic Effects of Equine-Assisted Psychotherapy
Equine-assisted interventions (EAI) are an emerging form of alternate psychotherapy that has been increasingly found to produce improvements in various treatment outcomes.
- Conditions
- Aggression, Stress, Psychopathy, Empathy
- Trial name
- EAP (NCT04200612)
- Testing
- Equine-Assisted Psychotherapy, Equine-Assisted Activities
- Where
- Singapore
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Chua Yi Rong Shawn
Intracranial Pressure Increase
Evaluation of the Effect of Trendelenburg Position Duration on Intracranial Pressure
The Lloyd Davies position is a position used in laparoscopic hysterectomies where the head is lowered 45 degrees and the legs are bent from the knee area.It is a version of the Trendelenburg position.
- Trial name
- NCT06048900
- Testing
- ultrasound guided optic nerve sheath diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Dilek Cetinkaya
Premature Infant
Effect of Increased Enteral Protein on Body Composition of Preterm Infants
The study hypothesis is that, in human milk-fed extremely preterm infants, higher protein intake compared to usual protein intake reduces percent body fat (%BF) at 3 months of age.
- Trial name
- NCT03586102
- Testing
- High protein supplementation, Standard protein supplementation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Alabama at Birmingham
Angina Pectoris
Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation.
- Trial name
- NCT00184444
- Testing
- Hypoxic interval training, Normoxic interval training
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Healthy
Randomized Study on Salt Intake and Energy Metabolism
To perform a randomized, double-blind clinical study on the effects of an increased salt intake on metabolic, cardiovascular and immunological parameters and the gut microbiota
- Trial name
- TS4 (NCT03024567)
- Testing
- Salt
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Stroke Rehabilitation
Mirror Feedback, Augmented Task-Specific, Impairment-Oriented Therapy, Home Practice, Stroke Rehabilitation
In this study, the investigators will (1) examine immediate and long-term effects of MT priming with task-specific training versus MT-priming with impairment-oriented training, relative to a dose-matched control therapy on motor…
- Trial name
- NCT04978311
- Testing
- Mirror therapy (MT) priming with task-specific training, Mirror therapy priming with impairment-oriented training, Control therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 21 people
- Sponsor
- National Taiwan University Hospital
Stroke
Effects of Augmented Reality Functional Integrated Training (AR-FIT) on Balance and Mobility in Stroke
The present study aims to develop and validate an evidence-based functional balance task library for Augmented Reality-Functional Integrated Training (AR-FIT), incorporating standardized real-object integration through expert…
- Trial name
- NCT07487207
- Testing
- Augmented Reality-Functional Integrated Training (AR-FIT) Group, Augmented Reality-Generic Balance Training (GBT) Group, Conventional Balance Training (CBT) Group
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Riphah International University
Diabetes Mellitus, Fat; Intolerance, Pancreas
Effect of Empagliflozin on Body Composition and Ketones
The purpose of this study is to evaluate changes of body composition induced by Sodium-glucose cotransporter-2 (SGLT2) inhibitor and its metabolic consequence in Korean type 2 diabetes (T2D).
- Trial name
- NCT03877406
- Testing
- Empagliflozin 10 MG, Hypoglycemics Oral
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Bundang Hospital
Overweight, Obesity
Effect of Chili Pepper Extract on Weight and Fat Loss and Metabolism Increase
The purpose of this study is to test the safety and effectiveness of a purified extract of CH-19 Sweet, containing capsinoids.
- Trial name
- NCT00825838
- Testing
- Chronic consumption of chili pepper extract
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ajinomoto USA, INC.
Cervical Dysplasia
Can Alternative Treatment Have an Impact on Cervical Dysplasia?
In this study two questions will be answered: can mindfulness meditation help cell-changed on the cervix to disappear? can mindfulness meditation lower the psychological distress when women have abnormal cervical cancer screening…
- Trial name
- NCT00842738
- Testing
- Mindfulness meditation, No meditation, Controls
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypothyroidism
Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding
The study aims to describe the changes in Levothyroxine dosage requirements in patients with hypothyroidism started on enteral feeding, and assess whether giving levothyroxine on empty stomach affects the mean percentage increase…
- Trial name
- NCT02577367
- Testing
- Levothyroxine
- Where
- United States
- Sponsor
- Jocelyne Karam
Hyperuricemia
Effect of Increased Daily Water Intake in Patients With Hyperuricemia
The purpose of this study is to explore the clinical effect of reducing uric acid by drinking water, and provide scientific evidence and clinical guidance for reducing uric acid by drinking water.
- Trial name
- NCT06315543
- Testing
- Drink water
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Xijing Hospital
HIV Infections
A Study on the Effect of High-Calorie Infant Formula on Growth and Nutrition in HIV-Infected Infants
This study examines the effects of an infant formula containing increased calories, as compared to commercial formulas, when given during the first 6 months of life.
- Trial name
- NCT00000873
- Testing
- Infant Formula
- Where
- 72 sites in United States, Brazil and 2 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adolescent Idiopathic Scoliosis
Augmented Reality-Based Exercise Training in Adolescents With Idiopathic Scoliosis
This randomized controlled trial investigates the effects of augmented reality (AR)-based exercise training in adolescents with idiopathic scoliosis.
- Trial name
- AR-SCOLIO (NCT07201103)
- Testing
- Conventional PSSE-Schroth, AR-Assisted PSSE-Schroth
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Organ Donation
Investigating Affective Attitude Question-behaviour Effects on Intention to Become an Organ Donor
The investigators aim to experimentally manipulate presence of questions on positive or negative affective attitudes to see if including these moderate as intention to become an organ donor.
- Trial name
- NCT02825862
- Testing
- Question-behaviour effect (for affective attitudes), Question-behaviour effect (negatively-worded attitudes)
- Where
- 4 sites in India, Ireland and 2 more
- Volunteers
- 999 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland