Clinical trials: Effect Neonatal
Vitamin D Receptor Target Gene Expression, Serum 25(OH)D Concentration
The Effect of a High-dose Oral Vitamin D3 Bolus on Serum 25(OH)D3 and Vitamin D Receptor Target Gene Expression
The purpose of the study is to investigate whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual variation.
- Trial name
- VitDbol (NCT02063334)
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Respiratory Distress, Transient Tachypnea of the Newborn
Effect of Supine or Prone Position After Caesarean Birth
Respiratory Distress is a frequent clinical diagnosis of babies delivered by elective Caesarean birth. There has been no study comparing the efficacy of immediately positioning a newly born infant prone vs.
- Conditions
- Respiratory Distress, Transient Tachypnea of the Newborn, Delayed Transition of the Newborn, Persistent Pulmonary Hypertension
- Trial name
- NCT01310153
- Testing
- prone positioning, Supine
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Education, Mobile Messages
Effects of Education on Breastfeeding
Objective: This study aims to investigate the effectiveness of education on breastfeeding and basic maternal-neonatal care and mobile message support given to primiparous women in the postpartum period on breastfeeding and…
- Conditions
- Education, Mobile Messages, Breastfeeding Self-efficacy, Breastfeeding Attitude
- Trial name
- NCT05998681
- Testing
- Breastfeeding and Basic Maternal-Neonatal Care and mobile messages
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hypogonadism
Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio, high insulin levels in the…
- Trial name
- NCT00470990
- Testing
- GnRH antagonist (Acyline)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kangaroo Care
The Effect of Mother and Father Kangaroo Care on Newborn and Parent Outcomes in Premature Infants
First aim is to determine the effect of mother and father kangaroo care on the premature baby's Comfort Behavior level and physiological parameters (respiratory rate, heart rate, oxygen saturation and body temperature).
- Trial name
- NCT06195410
- Testing
- kangaroo care application
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Gout
Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia
Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.
- Trial name
- NCT05454423
- Testing
- the Aquatic exercises +Traditional physical therapy programs +anti-hyperuricemia medication, traditional physical therapy + anti-hyperuricemia medication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Merit University
Infant, Premature, Diseases
Effect of Tactile-Kinesthetic Stimulation on Preterm Neonates
An interventional study to evaluate the effect of tactile-kinesthetic stimulation (TKS) on growth, neurobehavior and development among preterm neonates in the neonatal unit of Dr. Cipto Mangunkusumo Hospital.
- Trial name
- NCT04807088
- Testing
- Tactile-kinesthetic Stimulation
- Where
- Indonesia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Kidney Calculi
Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones
High amounts of calcium in the urine (hypercalciuria) can cause development of kidney stones in children. Treatment for these children includes plenty of fluids, a low-salt diet and medications such as potassium citrate.
- Trial name
- NCT00120731
- Testing
- Potassium Citrate, Acetazolamide, Diet low in oxalate and purines
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Healthy Volunteers, Sickle Cell Disease
A Study on the Effect of Etavopivat on Heart Rhythm in Healthy Participants
Novo Nordisk is developing a new study medicine, Etavopivat, to treat individuals with sickle cell disease (SCD). The purpose of the study is to determine the effect of Etavopivat on the electrical activity of the heart in…
- Conditions
- Healthy Volunteers, Sickle Cell Disease, Thalassemia
- Trial name
- NCT07023029
- Testing
- Etavopivat, Moxifloxacin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Wrinkle, Elastic Skin
Straberi Epistamp Needling Treatment For Skin Rejuvenation
This pilot study will expand knowledge and application needling using the Epistamp device for the improvement of a new vitalized epidermal layer with new vibrant active cells, supported by more robust collagen and elastin fine…
- Conditions
- Wrinkle, Elastic Skin, Collagen Degeneration
- Trial name
- ESAA (NCT04742803)
- Testing
- Straberi Epistamp Microneedling Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universal Skincare Institute
Uric Acid, Cardiovascular Diseases
Acute Effects of Tart Cherry on Uric Acid and Biomarkers of CVD Risk in Healthy Individuals
This study aims to provide evidence as to whether consumption of tart cherry juice can reduce the risk of gout and cardiovascular disease (CVD) in an acute context.
- Conditions
- Uric Acid, Cardiovascular Diseases, Gout
- Trial name
- NCT04960527
- Testing
- Tart cherry juice, Water
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Dyslipidemias, Familial Hypercholesterolemia
Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetcs and pharmacodynamics of single- and multiple doses of ARO-ANG3 in healthy adult volunteers and in dyslipidemic patients including familial…
- Conditions
- Dyslipidemias, Familial Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT03747224
- Testing
- ARO-ANG3, sterile normal saline (0.9% NaCl)
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Hypovitaminosis D, Pregnancy Complications
Effect of Vitamin D Replacement on Maternal and Neonatal Outcomes
The optimal vitamin D replacement dose during pregnancy remains undefined. Therefore, the aim of this study is to test the hypothesis that a daily equivalent dose of vitamin D of 3,000 IU/day is needed for Middle Eastern women…
- Conditions
- Hypovitaminosis D, Pregnancy Complications, Infant, Newborn, Diseases
- Trial name
- NCT02434380
- Testing
- Euro D
- Where
- Lebanon
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Healthy
Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants
This is a Phase 1, randomized, 2 way crossover, open label study of the effect of PF-04965842 on metformin (a probe for MATE1/2K activity) PK in healthy adult participants.
- Trial name
- NCT03796182
- Testing
- Metformin, PF-04965842
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Down Syndrome
Blood Flow Regulation in Individuals With Down Syndrome - Training Study
Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption.
- Trial name
- NCT04854122
- Testing
- Combined exercise intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Prader-Willi Syndrome, Self-Injurious Behavior
Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome
Prader-Willi syndrome (PWS) is a genetic disorder usually caused by the deletion of a specific gene. One of the symptoms of PWS is self-injurious behavior (SIB); a common form of SIB in PWS patients is skin picking.
- Trial name
- NCT00065923
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hereditary Angioedema
A Study of the Relative Bioavailability of a New Formulation of BCX4161 and the Effect of Food on BCX4161
The purpose of the study is to compare how the body takes up and then eliminates the study drug BCX4161 when it is taken orally as a hard gelatin capsule and as a soft gelatin capsule.
- Trial name
- NCT02125162
- Testing
- BCX4161
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Flatfoot, Flexible
The Effect of Insoles on Functional Performance in Pediatric Flexible Flatfoot
Flexible flatfoot is a condition that increase the load of the foot structure.With prolonged standing or walking, some children with flatfoot experience rapid discomfort or fatigue in the foot In this study, the investigators…
- Trial name
- NCT05533762
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Massage Therapy, Pregnancy Related
The Effects of Whole Body Prenatal Massage Therapy During Pregnancy: A Randomized Controlled Experimental Trial
Background: Massage therapy in many parts of the world is used in all periods of pregnancy. Aim: The study aimed to determine the effect of massage therapy during pregnancy on women and their fetuses in a university hospital in…
- Conditions
- Massage Therapy, Pregnancy Related, Fetus Fetus
- Trial name
- NCT05007210
- Testing
- Prenatal massage therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ege University
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