Clinical trials: Effectiveness
PreDiabetes
Examining the Impact of a Self-compassion Intervention on Physical Activity Behaviour Among People With Prediabetes
The investigators plan to examine whether teaching people at risk for type two diabetes to use self-compassion (orientation to care for oneself during difficult situations) helps them self-manage and increase their physical…
- Trial name
- NCT04863235
- Testing
- Control Group, Intervention Group
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gingivitis
The Efficacy of OrasaltsTM in the Treatment of Gingivitis
Gingivitis is defined as inflammation of the gingiva. It is a common disease that is prevalent in both children and adults, and in both genders .
- Trial name
- NCT02168335
- Testing
- OrasaltsTM, Sea salt
- Where
- South Africa
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Parenting Stress, Parent Child Relationship
Bashaoor Tarbiyat-e-Aulad Program for Reducing Parenting Stress
This randomized controlled trial evaluated the effectiveness of the culturally adapted Bashaoor Tarbiyat-e-Aulad (BTA) program, an Urdu adaptation of the Mindful Parenting Program developed by Bögels and Restifo, in reducing…
- Conditions
- Parenting Stress, Parent Child Relationship, Parent Stress
- Trial name
- NCT07802535
- Testing
- Bashaoor Tarbiyat-e-Aulad
- Where
- Pakistan
- Volunteers
- 127 people
- Sponsor
- National University of Modern Languages
Central Venous Catheter Care
SKİN PROTECTİVE BARRİER FİLM İN CENTRAL VENOUS CATHETER CARE İN INTENSİVE CARE PATİENTS
This randomized controlled study evaluated the effectiveness of a skin protective barrier film used during central venous catheter (CVC) care in adult intensive care unit patients.
- Trial name
- NCT07855835
- Testing
- Skin Protective Barrier Film, Standard Central Venous Catheter Dressing Care
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bezmialem Vakif University
Liver Failure
Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant Patients
The goal of this observational study is oo compare the pharmacokinetic parameters of different tacrolimus containing medications in liver transplant patients.
- Trial name
- LTA (NCT05744635)
- Testing
- Tacrolimus
- Where
- 2 sites in Hungary, Slovenia
- Volunteers
- 110 people
- Sponsor
- Chiesi Hungary Ltd.
Aspiration Skill Self-assessment, General Competence Belief
The Effect of Computer-Aided Simulation Training on Aspiration Skills and General Efficacy Beliefs
Purpose This study was conducted to determine the effect of computer-aided simulation education on nursing students' aspiration skills and general competence beliefs.
- Trial name
- NCT06800235
- Testing
- Computer-Assisted Simulation, Control grup
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Hepatocellular Carcinoma
Observation Study: Superselective Drug-Eluting Chemoembolization in Unresectable Intermediate and Advanced HCC Patients
The purpose of this multicenter registry is to gather the safety, efficacy and survival data in intermediate and advanced HCC patients treated drug-eluting microsphere in Taiwan in order to provide clinical evidence in HCC…
- Trial name
- NCT03273608
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Chronic Migraine, Chronic Migraine, Headache
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
This is a phase 2, double-blind, randomized, multicenter, placebo-controlled, three arm parallel study to evaluate the efficacy and safety of two different dosages (30 IU daily and 60 IU daily) of TNX-1900 in patients with…
- Conditions
- Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura, Aura Migraine
- Trial name
- PREVENTION (NCT05679908)
- Testing
- TNX-1900
- Where
- 26 sites in United States
- Volunteers
- 88 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Corneal Diseases, Effectiveness of Microdrops
Efficacy of Nanodropper-mediated Topical Anesthetic
The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a…
- Trial name
- NCT06636708
- Testing
- Nanodropper and Proparacaine HCl 0.5%, Standard Eye Drop Bottle with Proparacaine HCl 0.5%
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hypertension
A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen
A Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat an aldosterone synthase inhibitor (ASI), administered as an add-on to a standardized anti-hypertensive (AHT) medication regimen, in subjects with…
- Trial name
- NCT05769608
- Testing
- lorundrostat Dose 1, lorundrostat Dose 2
- Where
- 104 sites in United States
- Volunteers
- 285 people
- Sponsor
- Mineralys Therapeutics Inc.
Nonsmall Cell Lung Cancer
A Study to Evaluate Safety, PK and Efficacy of HS-10296 in Patients With NSCLC
This is a Phase 1/2, open-label, multicenter study of HS-10296 with dose escalation, dose expansion and extension cohorts in locally advanced or metastatic non-small-cell lung cancer (NSCLC) patients who have progressed following…
- Trial name
- NCT02981108
- Testing
- HS-10296
- Where
- 10 sites in United States
- Volunteers
- 364 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Obsessive Compulsive Disorder
Comparing the Effectiveness of Two Family-based Therapies in Treating Young Children With Obsessive-Compulsive Disorder
This study will compare the effectiveness of family-based cognitive behavioral therapy to family-based relaxation therapy in treating young children with obsessive-compulsive disorder.
- Trial name
- NCT00533806
- Testing
- Cognitive Behavior Therapy, Relaxation Therapy
- Where
- 3 sites in United States
- Volunteers
- 127 people
- Sponsor
- Rhode Island Hospital
Metastatic Colorectal Cancer
An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer (mCRC)
The purpose of this study is to examine the correlation between UGT1A1 genotypes and the efficacy of CPT-11 based regimens (FOLFIRI, CPT-11+S-1, CPT-11) for patients with metastatic colorectal cancer.
- Trial name
- NCT01039506
- Testing
- CPT-11 based regimens
- Where
- Japan
- Volunteers
- 1,376 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Analgesia
Comparing the Efficacy of Ultrasound Guided Erector Spinae Plane Block, Ultrasound Guided Caudal Block, and Local Infiltration for Postoperative Pain Control in Pediatric Patients Undergoing Unilateral Inguinal Hernia Repair as a Day-Case Surgeries: A Randomized Controlled Trial
The aim of this study is to evaluate the efficacy of ultrasound guided Erector block versus caudal block versus local wound infiltration perioperatively according to: Primary outcome: to assess and compare the postoperative…
- Trial name
- ECLU (NCT06849804)
- Testing
- Erector Spinae (ESP) Block with Bupivacaine (Marcaine®), Caudal Block Anesthesia, Local infiltration in the wound
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tanta University
Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.
- Trial name
- NCT06713733
- Testing
- Dexamethasone, Chymotrypsin
- Where
- Nepal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Maculopathy
Ozonized Oil as Dietary Supplement in Macular Degeneration
Macular degeneration, also called age-related macular degeneration (AMD), is a leading cause of visual impairment and severe vision loss. AMD is a disease with a multifactorial etiology.
- Trial name
- NCT06351033
- Testing
- High ozonide (HOO) ozonated oil
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Alba Di Pardo
Mammary Neoplasms, Human
The Efficacy and Safety of Eutideron, Etoposide, and Bevacizumab in Patients With Brain Metastases From Breast Cancer.
This study was a single-arm, open-label, phase II study of breast cancer patients with brain metastases. Eligible patients received a regimen of eutidrone(30mg/m2/d,iv,d1-5,21d/cycle), etoposide(30mg/m2/d,iv,d1-3,21d/cycle), and…
- Trial name
- NCT05781633
- Testing
- eutidrone etoposide bevacizumab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Post Operative Analgesia
Comparison of Efficacy of Bupivacaine Alone vs. Bupivacaine-Tramadol in Lower Limb Surgery
This randomized controlled trial aims to compare the effectiveness of bupivacaine alone versus bupivacaine combined with tramadol for postoperative analgesia in patients undergoing lower limb surgeries under spinal anesthesia.
- Trial name
- BUP-TRA-PAIN (NCT07827352)
- Testing
- Bupivacain only, bupivacain-tramadol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Farooq Hospital / Akhtar Saeed Medical college Rawalpindi
Painful Diabetic Neuropathy
A Clinical Trial to Study the Effects of GRC 17536 in Patients With Painful Diabetic Neuropathy (Painful Extremities Due to Peripheral Nerve Damage in Diabetic Patients)
Diabetic peripheral neuropathy (DPN) represents a diffuse symmetric and length-dependent injury to peripheral nerves that has major implications on quality of life (QOL), morbidity, and costs from a public health perspective.
- Trial name
- NCT01556152
- Testing
- GRC 17536 (Medium Dose), GRC 17536 (Low Dose)
- Where
- 2 sites in Germany, United Kingdom
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Postoperative Analgesia
Evaluation of Safety and Efficacy of Nalbuphine Versus Morphine for Postoperative Analgesia
Evaluation of safety and efficacy of Nalbuphine versus Morphine patient controlled intravenous analgesia (PCIA) for the treatment of postoperative analgesia
- Trial name
- NCT06949852
- Testing
- Nalbuphine Hydrochloride Injection, Morphine Hydrochloride Injection
- Where
- 24 sites in China
- Volunteers
- 289 people
- Sponsor
- Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd
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