Clinical trials: Effects, Longterm
Chronic Obstructive Pulmonary Disease
Long-term Effect of an Health Education Program on Daily Physical Activity in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Main objective: To compare the level of physical activity (PAL) at 12 months in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) between those who completed a health education program and those…
- Trial name
- EA-EPOC (NCT02924870)
- Testing
- Health education program, Conventional management
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Universitario La Paz
Dry Eye
Long-term Effects of Acoltremon vs. Control in Dry Eye Disease
This is a prospective, longitudinal, single-center study designed to evaluate the long-term changes in symptoms and tear production in subjects with dry eye disease.
- Trial name
- NCT07659626
- Testing
- Acoltremon 0.003%, Refresh classic preservative free
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Eye Care Institute
Spinal Cord Injuries
Long-term Effect of Hypnosis in Spinal Cord Injury Patients
Coping-oriented hypnotic suggestions aimed at reducing pain catastrophizing was shown to reduce pain in people with chronic tension-type headache and experimental pain in healthy volunteers during hypnosis (Kjøgx et al., 2016).
- Trial name
- NCT03063333
- Testing
- Coping-oriented hypnosis, Neutral hypnosis
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Lone Knudsen, MSc Psych, PhD
Anemia, Iron Deficiency (Without Anemia)
The Immediate and Long-term Effects of a Novel Marine-based Iron Supplement in Adult Females
The goal of this study is to identify how well a fish-based iron supplement is absorbed and to learn how many, if any, digestive related side effects are caused by ingesting the supplement.
- Conditions
- Anemia, Iron Deficiency (Without Anemia), Iron Absorption
- Trial name
- NCT07199244
- Testing
- marine-based heme iron
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Cicatrix
Observational Study for the Long-Term Effects of a Dermal Substitute on Patients With Facial Burns.
The aim of this observational study is to investigate the long-term (between 10-20 years) results for the surgical treatment of third degree burn injury in the face and/or the neck by means of Integra® Dermal Regeneration…
- Trial name
- NCT03971968
- Testing
- Skin replacement with artificial skin
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitair Ziekenhuis Brussel
Feeding Difficulties, Feeding Problems
Long-Term Effect of Online Occupational Therapy-Based Parent Training on Feeding Problems in Infants
This study type is a clinical trial (randomized controlled longitudinal study). The primary purpose is to determine whether an online occupational therapy-based parent training program can prevent or reduce feeding problems…
- Conditions
- Feeding Difficulties, Feeding Problems, Food Neophobia
- Trial name
- NCT07050927
- Testing
- Online occupational therapy group training
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Parkinson Disease
Long-term Effects of Combined Balance and Brisk Walking in Parkinson's Disease
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized with both clinical motor and non-motor features, as well as decrease in balance performance and walking endurance.
- Trial name
- NCT04665869
- Testing
- Combined balance and brisk walking training, Flexibility and strengthening exercise
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Endothelial Dysfunction, Biochemical Markers
Acute Effects of E-Cigarette Aerosol Inhalation
This study comprises a portion of a larger study designed to compare results of vascular function in non-smokers to vascular function in healthy smokers chronically exposed to nicotinized electronic cigarette aerosol versus…
- Trial name
- NCT03479203
- Testing
- Electronic Cigarette Aerosol
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Severe Depression
Psilocybin and Depression
The main aim of the study is to investigate the possible long-term therapeutic effects of psilocybin on the symptoms of severe depression, as well as the brain mechanisms underlying these changes.
- Trial name
- Psilo101 (NCT03380442)
- Testing
- Psilocybin, Ketamine (Ketalar)
- Volunteers
- 60 people
- Sponsor
- University of Helsinki
Age Related Maculopathy
Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation on Optical Density of AMD Patients (LUTEGA)
The primary objective of LUTEGA is it to determine the long term effect (about 1 year) of the supplementation with a fixed combination of lutein/zeaxanthin and omega-3- fatty acids on the optical density (OD) of macular pigment…
- Trial name
- LUTEGA (NCT00763659)
- Testing
- Lutein/ Zeaxanthin + Omega-3-FA
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- University of Jena
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Transsexualism
Observational Study on Metabolism and Psychopathology in Transsexual Patients
Gender identity disorders (also known as transsexualism) is defined as a condition in which a person with apparently normal somatic sexual differentiation is convinced that he or she is actually a member of the other sex.
- Trial name
- NCT02185274
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Plantar Fascitis, Achilles Tendon Pain
Effect of HILT vs LLLT in Treatment of Patients With Achilles Tendinitis or Plantar Fasciitis
The aim of this study is to evaluate and compare the changes of heel pain, functional health and well-being after high-intensity and low-level laser therapy for plantar fasciitis or Achilles tendinopathy
- Trial name
- NCT03873961
- Testing
- High-intensity laser therapy, Low-level Laser therapy
- Where
- Lithuania
- Volunteers
- 155 people
- Sponsor
- Lithuanian University of Health Sciences
Long-term Effects Secondary to Cancer Therapy in Children, Neuroblastoma
Observation of Young Patients With Localized Neuroblastoma Who Have Undergone Surgery Only
RATIONALE: Observation is closely monitoring a patient's condition and not giving treatment until symptoms appear or change. Observation may help doctors see how effective surgery is in treating neuroblastoma.
- Trial name
- NCT00416559
- Testing
- clinical observation
- Volunteers
- 140 people
- Sponsor
- Children's Cancer and Leukaemia Group
Coronary Artery Disease
Long-term Effects of Individualized Follow-up With an App for One Year
The aim of this study is to examine the long-term (3-5 year post intervention) effects post individualized follow-up with an app for one year, compared to a control group that received usual care on factors related to healthy…
- Trial name
- NCT05697120
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Oslo Metropolitan University
Skin Pigmentation Over Contour Deformities of Face, Trauma, Rhomberg Disease
Long Term Effects on Skin Hyper Pigmentation With and Without Mesenchymal Stem Cell Enriched Adipose Tissue Grafting for "Contour Deformities With Pigmentary Changes on Face"
MSCs one injected along with fat, regulate pigmentation over the contour defects of face
- Trial name
- MSCs (NCT03564808)
- Testing
- MSC
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Children Born Extremely Premature, Disturbance of Visuo-spatial Working Memory
Long-term Effects of Visual Spatial Working Memory Training Program Performed at Preschool Age in Very Preterm Infants With Visual Spatial Working Memory Deficit. A Randomized Controlled Trial
Prematurity tends to increase in France in recent years and more children born extremely premature infants survive. If severe impairments have stabilized, the majority of former extremely premature children have…
- Trial name
- EPIREMED (NCT02757794)
- Testing
- computerized cognitive remediation program, standard remediation
- Where
- 18 sites in France
- Volunteers
- 166 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Electrophysiology
Study of the Long-Term Effect of Frequent Anti-VEGF Dosing on Retinal Function in Patients With Neovascular AMD
THis study aims to determine whether frequent dosing of intravitreal injections of Ranibizumab (Lucentis) or Bevacizumab (Avastin), which act as VEGF inhibitors, has a deleterious effect on the retina, studied by…
- Trial name
- NCT00533689
- Testing
- Electroretinography (ERG), Visual Evoked Potentials (VEP)
- Where
- Israel
- Volunteers
- 2,008 people
- Sponsor
- Tel-Aviv Sourasky Medical Center