Clinical trials: Effects, Longterm
Colitis, Ulcerative, Crohn's Disease
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- NCT02620046
- Testing
- Vedolizumab SC
- Where
- 301 sites in United States, Argentina and 31 more
- Volunteers
- 746 people
- Sponsor
- Takeda
Diffuse Astrocytoma, Anaplastic Astrocytoma
Pediatric Long-Term Follow-up and Rollover Study
A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.
- Conditions
- Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
- Trial name
- NCT03975829
- Testing
- dabrafenib, trametinib
- Where
- 54 sites in United States, Argentina and 17 more
- Volunteers
- 163 people
- Sponsor
- Novartis Pharmaceuticals
Post-dural Puncture Headache, Post-dural Puncture Backache
Long-term Effects of Accidental Dural Puncture in Patients Having Had an Epidural Blood Patch (LEAP)
Accidental dural puncture (ADP) during placement of an epidural catheter for anesthesia and analgesia is a well known complication. Previous studies have found audiometric deterioration following ADP.
- Trial name
- LEAP (NCT02149680)
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Periodontitis, Periodontal Pocket
Amoxicillin Plus Metronidazole in Periodontal Maintenance
Gum disease require a lifetime supportive periodontal care aiming at preventing additional inflammation and bone resorption. During this phase it is also relevant to keep germs under acceptable levels through proper daily hygiene…
- Trial name
- NCT05934227
- Testing
- Amoxicillin 500 milligrams capsules plus metronidazole 400 milligrams
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Minas Gerais
Electrophysiology
Study of the Long-Term Effect of Frequent Anti-VEGF Dosing on Retinal Function in Patients With Neovascular AMD
THis study aims to determine whether frequent dosing of intravitreal injections of Ranibizumab (Lucentis) or Bevacizumab (Avastin), which act as VEGF inhibitors, has a deleterious effect on the retina, studied by…
- Trial name
- NCT00533689
- Testing
- Electroretinography (ERG), Visual Evoked Potentials (VEP)
- Where
- Israel
- Volunteers
- 2,008 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Morbid Obesity
Long Term Effects of Weight Loss on Post-prandial Gut Hormone Responses and Meal Induced Thermogenesis
A study to examine post-prandial gut-hormone secretion, meal-induced thermogenesis, fasting plasma metabolomic/lipidomic and cardiovascular indices among surgically managed obese individuals in the long term compared to…
- Trial name
- NCT04170010
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- National and Kapodistrian University of Athens
Brain and Central Nervous System Tumors, Long-term Effects Secondary to Cancer Therapy in Children
Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma
RATIONALE: Specialized radiation therapy that delivers radiation directly to the area where a tumor was surgically removed may kill any remaining tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00105560
- Testing
- radiation therapy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital
Obesity
Vitamin D Supplementation in Vitamin D Deficient Obese Children During Weight-loss Program
1. Analyze the influence of vitamin D supplementation in obese children during weight-loss program on BMI, body composition and bone mineral density. 2.
- Trial name
- NCT02828228
- Testing
- Vitamin D 1200 IU
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University Clinical Centre, Gdansk
HIV Infections, HIV-Associated Lipodystrophy Syndrome
Follow-up on the HIGH: Low Study - the Longterm Effects of Growth Hormone
A follow-up study on the randomized, controlled, double-blind HIGH: low study. We will examine the participants from the HIGH: low study min. 6 months after finishing the HIGH: low study.
- Trial name
- NCT00662181
- Where
- Denmark
- Volunteers
- 46 people
- Sponsor
- Hvidovre University Hospital
Coinfection With Hepatitis B Virus and Hepatitis C Virus, Monoinfection With Hepatitis C Virus
Long Term Effects of Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C/B Co-Infection and Chronic Hepatitis C
Chronic hepatitis C may relapse in simple chronic hepatitis C patients who initially obtained sustained virologic responses. Although the HCV SVR could be maintained in around 90%, the remaining 10% of these patients may develop…
- Trial name
- NCT00361179
- Where
- China
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Obesity
Short- and Longterm Effects of Physical Activity and Dietary Restriction Postpartum
The study will investigate whether physical exercise, or dietary restrictions, or a combination of both, among overweight and obese postpartum women lead to a significantly larger reduction in weight in a longer perspective…
- Trial name
- LEVA (NCT01343238)
- Testing
- Diet, Exercise, Diet and Exercise
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Göteborg University