Clinical trials: Effects, Longterm
Severe Depression
Psilocybin and Depression
The main aim of the study is to investigate the possible long-term therapeutic effects of psilocybin on the symptoms of severe depression, as well as the brain mechanisms underlying these changes.
- Trial name
- Psilo101 (NCT03380442)
- Testing
- Psilocybin, Ketamine (Ketalar)
- Volunteers
- 60 people
- Sponsor
- University of Helsinki
Mood Disorders, Anxiety Disorders
First Experimental Study of Transference-Interpretations (FEST)
Analysis of the ongoing patient-therapist interaction, the transference, is considered a key active ingredient in psychoanalytically oriented psychotherapy and psychoanalysis.However, one century after Sigmund Freuds's famous…
- Conditions
- Mood Disorders, Anxiety Disorders, Personality Disorders
- Trial name
- NCT00423462
- Testing
- Brief dynamic psychotherapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Crohn Disease, Colitis, Ulcerative
A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
The primary objective of the study is to evaluate the efficacy of 2 different maintenance dose regimens of TEV-48574 subcutaneous (sc) administered every 4 weeks (Q4W) in adult participants with inflammatory bowel disease (IBD).
- Trial name
- NCT05668013
- Testing
- TEV-48574 Dose Regimen A, TEV-48574 Dose Regiment B
- Where
- 93 sites in United States, Austria and 14 more
- Volunteers
- 247 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Primary Aldosteronism
The Long-term Effect of SAAE and Medical Treatment for Primary Aldosteronism
In this prospective controlled trial, we aim to determine whether superselective adrenal artery embolization is superior to medical treatment for patients with PA who refuse surgery for medication.
- Trial name
- NCT05262660
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Breast Cancer, Chemotherapeutic Agent Toxicity
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
RATIONALE: Gathering information over time from laboratory tests, imaging scans, and assessment tests may help doctors learn more about the side effects of chemotherapy and plan the best treatment.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Fatigue
- Trial name
- NCT00755313
- Testing
- trastuzumab, aromatase inhibition therapy, carboplatin
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes Mellitus, Type 2
Long-Term Effects of Sucontral(TM) on Mild and Moderate Cases of Diabetes Mellitus (Type 2)
In patients with diabetes mellitus type 2 stably adjusted to diet long-term intake of aqueous-ethanolic extract from Hintonia latiflora over more than 12 months leads to a statstically significant amelioration of parameters of…
- Trial name
- NCT00315718
- Testing
- Extract from Hintonia latiflora bark
- Where
- Slovakia
- Volunteers
- 10 people
- Sponsor
- Harras Pharma Curarina GmbH
Newborn Morbidity, Pain
Epidemiology of Painful Procedures in Neonates
Sick or premature neonates are exposed to frequent painful and stressful procedures during their stay in neonatal intensive care units.
- Conditions
- Newborn Morbidity, Pain, Procedures, Intratracheal Intubation
- Trial name
- EPIPPAIN (NCT01346813)
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Hôpital Armand Trousseau
Laryngectomy; Status
Long Term Effects of Heat and Moisture Exchangers (HMEs)
Assessment of long term effect of Provox Life HME use on pulmonary symptoms in laryngectomized patients.
- Trial name
- NCT06084611
- Testing
- Provox Life
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Atos Medical AB
Becker Muscular Dystrophy
Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy
EDG-5506-203 MESA is an open-label extension study to assess the long-term effect of sevasemten (EDG-5506) on safety, biomarkers, and functional measures in adults and adolescents with Becker muscular dystrophy
- Trial name
- MESA (NCT06066580)
- Testing
- Sevasemten
- Where
- 48 sites in United States, Australia and 10 more
- Volunteers
- 260 people
- Sponsor
- Edgewise Therapeutics, Inc.
Pain
Effect of Dry Needling on Myofascial Trigger Point
Myofascial trigger point is one of the most common causes of musculoskeletal disorders. Myofascial trigger point in upper trapezius has been reported as a symptom in patients with neck and upper thoracic pain.
- Trial name
- NCT02107456
- Testing
- Dry Needling
- Where
- Iran
- Volunteers
- 33 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Hemorrhoids
Ligasure Hemorrhoidectomy Versus Open Hemorrhoidectomy
This is a single center randomized clinical trial comparing Ligasure Hemorrhoidectomy and Open Hemorrhoidectomy for the treatment of prolapsing haemorrhoids.
- Trial name
- NCT04139876
- Testing
- Open Haemorrhoidectomy, LigaSure Hemorrhoidectomy
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Holbaek Sygehus
Spinal Cord Injuries, Neuralgia
Long-term Effects of Repetitive TMS in Chronic Neuropathic Pain in People With SCI
Around 80% of people with spinal cord injury (SCI) develop chronic neuropathic pain (CNP). This is a debilitating condition with major negative impacts on people's quality of life.
- Conditions
- Spinal Cord Injuries, Neuralgia, Chronic Pain
- Trial name
- NCT05226676
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Interstitial Lung Diseases, Systemic Sclerosis Associated Interstitial Lung Disease
A Study Using a Disease Registry to Observe the Long-term Effects of Nintedanib in People With Scleroderma-related Lung Fibrosis
This post-approval registry study is planned to generate data to address remaining questions on long-term effectiveness and to better characterize longer term beneficial effects of Nintedanib in patients with systemic sclerosis…
- Trial name
- NCT07080125
- Testing
- Ofev®
- Where
- Switzerland
- Volunteers
- 2,000 people
- Sponsor
- Boehringer Ingelheim
Patellofemoral Pain Syndrome, Patellofemoral Pain
Long-term Effects of the Addition of Diathermy by Emission of Radiofrequency to Therapeutic Exercise in Patellofemoral Pain Syndrome Patients
Introduction: the management of Patellofemoral Pain (PFP) is focused on therapeutic exercise (TE) to improve muscle strength and motor control.
- Conditions
- Patellofemoral Pain Syndrome, Patellofemoral Pain, Patello Femoral Syndrome
- Trial name
- NCT05471089
- Testing
- Diathermy by emission of Radiofrequency, Therapeutic exercise
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- University of Jaén
Chronic Migraine
A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency
The purpose of this study is to evaluate sustained tolerability, quality of life, and change in cognitive efficiency following treatment with OnabotulinumtoxinA and daily topiramate vs.
- Trial name
- NCT01700387
- Testing
- onabotulinumtoxinA, Topiramate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cady, Roger, M.D.
Diabetes Mellitus, Heart Failure
Sodium-glucose Co-transporter 2 Inhibitors Effects in Failing Heart Patients
SLGT2 therapy is safety used in heart failure (HF) patients with depressed left ventricle ejection fraction (LVEF) and diabetes mellitus (DM).
- Conditions
- Diabetes Mellitus, Heart Failure, Ventricular Arrythmia
- Trial name
- NCT03977116
- Testing
- SLGT2
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Aspirin, Drug Safety
Pharmacy Based Pharmacoepidemiological Observational Study With Aspirin Protect 100 mg
In this non-interventional one year study, data about overall and particularly gastrointestinal tolerability, indications, cardiovascular risk factors and compliance are collected by basic questionnaires, which are handed out by…
- Conditions
- Aspirin, Drug Safety, Effects, Longterm
- Trial name
- NCT01669824
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465)
- Where
- Germany
- Volunteers
- 4,235 people
- Sponsor
- Bayer
Non-Specific Chronic Low Back Pain
Non-Specific Chronic Low Back Pain Treatment Methods
In Turkish society, almost all people experience back pain. When this pain lasts longer than 3 months and is not related to any cause, it is called "non-specific chronic back pain".
- Trial name
- NCT07057687
- Testing
- Conventional Physical Therapy Group, Relaxation Techniques Group, Mulligan Treatment Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Medipol University Hospital
Attention Deficit Disorder With Hyperactivity
Adherence and Long-term Effect of OROS Methylphenidate (CONCERTA): A Follow-up Study
The objectives of this study are to investigate: 1. the evolution of ADHD symptoms, remission rate of ADHD, social and school function, and familial relationship; 2.
- Trial name
- NCT00598182
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Blood and Marrow Transplant (BMT)
Long Term Effects On Recipients of Hematopoietic Stem Cell Transplantation
This project allows for the systematic collection and analysis of long-term follow-up clinical parameters in children who have received a stem cell transplant.
- Trial name
- NCT01629017
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Stanford University