Clinical trials: Effects of Chemotherapy
Bile Duct Cancer, Chemotherapy Effect
DDR-Umbrella Study of DDR Targeting Agents in Advanced Biliary Tract Cancer
To assess the effect of AZD6738 and Durvalumab combination or AZD6738 and Olaparib combination in biliary tract cancer patients who have failed to 1st-line chemotherapy.
- Trial name
- NCT04298021
- Testing
- AZD6738, Durvalumab, Olaparib
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer, Chemotherapy Effect
Pembrolizumab Plus Chemotherapy in 1st Line Treatment of Pancreatic Cancer
This is an open-label, phase 2 study of Pembrolizumab in combination with chemotherapy in chemotherapy-naïve advanced pancreatic cancer
- Trial name
- NCT04447092
- Testing
- Gemcitabine, Nab-paclitaxel, Pembrolizumab
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Hospital
Cancer, Ovarian, Chemotherapy Effect
Fasting Mimicking Diet in Chemotherapy of Gynecologic Malignancies
This study evaluates how lifestyle modifications that may be made to manage chemotherapy side effects in patients with gynecologic malignancies.
- Conditions
- Cancer, Ovarian, Chemotherapy Effect, Calorie Deficiency, Fasting, Intermittent
- Trial name
- NCT06376604
- Testing
- Fasting Mimicking Diet, Chemotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- L-Nutra Inc
Colorectal Cancer, Surgery
MRD Application in Colorectal Cancer Patients
We first collect tumor tissue and adjacent tissue to peform the WES sequencing, then collect blood after postoperative surgery 1, 3. 6, 9, 12, 18, 24 month to detect ctDNA.
- Conditions
- Colorectal Cancer, Surgery, Chemotherapy Effect
- Trial name
- NCT06028516
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong First Medical University
Breast Cancer, Chemotherapy Effect
The Prediction Model of NAC Response for Breast Cancer Based on The Parametric Dynamics Features.
The main purpose of this study is to develop a computer-aided prediction model for NAC treatment response. Based on the heterogeneity of internal parametric tumor composition commonly observed, this study will utilize the…
- Conditions
- Breast Cancer, Chemotherapy Effect, Diffusion Weighted MRI, PET Imaging
- Trial name
- NCT06370234
- Testing
- Whole body 18F-FDG Positron Emission Tomography
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Vitamin D Deficiency, Chemotherapy Effect
Vitamin D Can Increase Pathological Response of the Breast Cancer Patients Treated With Neoadjuvant Therapy
The aim of the study is to evaluate the relationship between the vitamin D replacement and pathological response in patients undergoing neoadjuvant therapy according to different molecular sub types.
- Conditions
- Vitamin D Deficiency, Chemotherapy Effect, Pathology
- Trial name
- NCT03986268
- Testing
- Vit D
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
Dysgeusia, Acupressure
Application of Auricular Point Sticking in Patients With Taste Alteration
To explore the intervention effect of auricular point sticking on chemotherapy-induced taste alterations in cancer patients, and analyze its relationship with quality of life, nutritional status and psychology of patients.
- Conditions
- Dysgeusia, Acupressure, Chemotherapy Effect
- Trial name
- NCT05868850
- Testing
- auricular point sticking
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiangnan University
Stomach Cancer, Gastric Cancer
Docetaxel and Irinotecan in Gastric Cancer
To assess the role of docetaxel and irinotecan combination in second line gastric cancer. The primary end point is response rate. Secondary end points are toxicity, PFS and OS.
- Conditions
- Stomach Cancer, Gastric Cancer, Chemotherapy Effect
- Trial name
- NCT04770623
- Testing
- Docetaxel, Irinotecan
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Menoufia University
Gynecologic Cancer, Ovarian Cancer
Role of the ATP7A Transporter in Ovarian Cancer
Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting with advanced stage tumors.
- Conditions
- Gynecologic Cancer, Ovarian Cancer, High Grade Serous Carcinoma, Chemotherapy Effect
- Trial name
- ATHOC (NCT05490407)
- Testing
- Carboplatin
- Where
- 2 sites in Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Colorectal Neoplasms, Chemotherapy Effect
Other Oncogene Mutations for Anti-EGFR Efficacy in Patients With Left-sided RAS-wild Type Metastatic Colorectal Cancer
Patients meeting the inclusion criteria will be randomized 1:1 into Cohort A (n ≈ 177) or Cohort BC (n ≈ 177). Cohort A is the control: patients receive combination chemotherapy with FOLFOX plus anti-EGFR therapy (panitumumab or…
- Conditions
- Colorectal Neoplasms, Chemotherapy Effect, Molecular Sequence Variation
- Trial name
- CRC01 (NCT06226857)
- Testing
- Cetuximab
- Where
- 3 sites in Russia
- Volunteers
- 355 people
- Sponsor
- City Clinical Oncology Hospital No 1
Breast Cancer Metastatic, Chemotherapy Effect
Effect of Low Dose Metronomic Chemotherapy in Metastatic Breast Cancer
Low dose metronomic chemotherapy (LDMC) in patients with metastatic breast cancer (MBC) is used as a palliative regiment with the aim to prolong and improve quality of life. The effect of LDMC is not fully elucidated.
- Trial name
- METRO (NCT04350021)
- Testing
- Capecitabine, Cyclophosphamide
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Depression, Anxiety
The Effect of Music During Chemotherapy
Purpose: Chemotherapy treatment is a very different and difficult process. Considering the many physiological and psychological problems that patients experience during and after the treatment process, chemotherapy symptoms and…
- Conditions
- Depression, Anxiety, Stress, Chemotherapy Effect
- Trial name
- EMDC (NCT06180629)
- Testing
- Music conset, normal treatment routine
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Chemotherapy Effect
Evaluation of a Mobile App to Promote Social Support for Oncology Patients
Our study will evaluate patient and caregiver use of a new mobile application (app) to support patients undergoing chemotherapy treatment for cancer.
- Trial name
- NCT04331678
- Testing
- Comparator App
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- West Cancer Center
Metastatic Colorectal Cancer, Chemotherapy Effect
Rechallenge of Prior Regimen in Third or Later-line Chemotherapy in Metastatic Colorectal Cancer
This is a single-arm, open-label, single-center prospective phase II study to evaluate the efficacy and safety of rechallenge chemotherapy in the third or later-line treatment in patients with advanced colorectal cancer.
- Trial name
- NCT03485027
- Testing
- the rechallenge regimen
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fudan University
Colorectal Cancer Metastatic, Tumour Metastasis
Evaluation of Tumour Growth and Oncological Treatment in Patients With CRLM Using Zebra Fish Embryo Model
In order to improve and individualize cancer treatment, personalized treatment needs to be developed much further. Liver metastasizing colorectal cancer is treated with a combination of oncological and surgical interventions.
- Conditions
- Colorectal Cancer Metastatic, Tumour Metastasis, Chemotherapy Effect, Tumor Growth
- Trial name
- CRLM-Z (NCT05289076)
- Testing
- Chemotherapy drug
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- University Hospital, Linkoeping
Chordoma, Chemotherapy Effect
Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma
This phase II trial studies how well Camrelizumab combined with Apatinib work in treating participants with chordoma that has spread to other places in the body, which may interfere with the ability of tumor cells to grow and…
- Trial name
- NCT06140732
- Testing
- camrelizumab and apatinib
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Gastric Cancer, Gastric Adenocarcinoma
Perioperative Leucovorin, Oxaliplatin, Docetaxel and S-1 (LOTS) For Locally Advanced Gastric or Gastroesophageal Junction Cancer
The aim of the trial is to investigate the clinical efficacy and toxicity of perioperative chemotherapy with leucovorin, oxaliplatin, docetaxel and S-1 (LOTS) in patients with locally advanced gastric or gastroesophageal junction…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Effects of Chemotherapy, Toxicity Due to Chemotherapy
- Trial name
- LOTS (NCT04999332)
- Testing
- leucovorin, oxaliplatin, docetaxel, S-1
- Where
- 4 sites in Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Anxiety, Chemotherapy Effect
The Effect of Music Applied During Chemotherapy on Anxiety, Nausea and Satisfaction Levels
Chemotherapy is a treatment that uses natural or synthetic chemicals and biological agents to kill rapidly proliferating cells. As chemotherapeutic drugs prevent the growth and proliferation of cancer cells, they also inhibit the…
- Conditions
- Anxiety, Chemotherapy Effect, Satisfaction, Patient, Cancer
- Trial name
- NCT05687838
- Testing
- Music
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uludag University
Gastric Cancer, Chemotherapy Effect
Predicting Biomarker of Gastric Cancer Chemotherapy Response
discovery and validation of biomarker predicting gastric cancer chemotherapy response Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response Analysis for…
- Conditions
- Gastric Cancer, Chemotherapy Effect, Predictive Cancer Model
- Trial name
- NCT03253107
- Testing
- Chemotherapy
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Kyungpook National University Hospital
Myelodysplastic Syndrome, Effects of Chemotherapy
Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery
Broadly speaking, the goal of this study is to better understand the influence of chemotherapy treatment on the cognitive and neural mechanisms underlying human behavior.
- Conditions
- Myelodysplastic Syndrome, Effects of Chemotherapy, Mild Cognitive Impairment, Multiple Myeloma
- Trial name
- Chemobrain (NCT02767388)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nebraska