Clinical trials: Ejection Fraction
Heart Failure
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure.
- Trial name
- 8282-Reduced (NCT06979375)
- Testing
- CDR132L
- Where
- 92 sites in Australia, Czechia and 8 more
- Volunteers
- 200 people
- Sponsor
- Novo Nordisk A/S
Heart Failure, Diastolic, Coronary Artery Disease
Assessment of Functional Capacity and Inflammatory Markers in Women With Heart Failure With Preserved Ejection Fraction
This study assesses the impact of diastolic heart failure on exercise capacity in women who have a previous coronary condition. All the participants will go through the same evaluation.
- Conditions
- Heart Failure, Diastolic, Coronary Artery Disease, Inflammation
- Trial name
- NCT02649400
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Stable Ischemic Heart Disease, Coronary Artery Disease
De-Adoption of Beta-Blockers in Patients With Stable Ischemic Heart Disease
Patients with heart disease are often prescribed many medications and these patients may experience drug interactions or negative drug related side effects.
- Conditions
- Stable Ischemic Heart Disease, Coronary Artery Disease, Beta-blocker Therapy
- Trial name
- ABBREVIATE (NCT05081999)
- Testing
- Medical Assessment, Quality of Life Assessment
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of Alberta
Heart Failure
Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction
Heart failure (HF) affects more than 6 million adults in the U.S. alone, with increasing prevalence. Cardiovascular congestion with resultant limitation in physical activity is the hallmark of chronic and decompensated HF.
- Trial name
- Splanchnic X (NCT06733012)
- Testing
- Splanchnic nerve block
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Duke University
Heart Failure With Preserved Ejection Fraction (HFpEF), Sarcopenia
Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quality of Life
This prospective study will randomize (1:1) women with heart failure with preserved ejection fraction (HFpEF) and sarcopenia to receive standard management alone or a combined 12-week supervised exercise program (combining…
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFpEF), Sarcopenia, Women
- Trial name
- TRAIN-SARC (NCT06655532)
- Testing
- Exercise Program, Usual Care
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure With Reduced Ejection Fraction
Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure
This a single-center, retrospective, observational study of patients that undergo coronary sinus(CS) lead revision, comparing epicardial lead placement to coronary sinus pacing(CSP) in those that had lead failure.
- Trial name
- NCT06342492
- Testing
- Coronary Sinus Lead Revision
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Heart Failure, Left Bundle Branch Pacing
Clinical Efficacy of Early Left Bundle Branch Pacing for Cardiac Resynchronization Therapy
This is a two-center, prospective randomized controlled trial. The aim of this study is to compare the clinical efficacy of early left bundle branch pacing for cardiac resynchronization therapy and guideline-directed medical…
- Trial name
- Early-RESYNC (NCT06126081)
- Testing
- LBBP+GDMT, GDMT
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Heart Failure, Heart Failure With Reduced Ejection Fraction
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Obesity, Overweight
- Trial name
- SLEnDR (NCT05942287)
- Testing
- Diet intervention
- Where
- 2 sites in Jersey, United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Heart Failure With Reduced Ejection Fraction
Comparing ARNI With ACE Inhibitor on Endothelial Function
PARADOR is multisite, randomized, double-blind, phase IV clinical trial to compare the effect of sacubitril/valsartan (Entresto™) to enalapril (Vasotec®) on blood vessel function in subjects with heart failure with reduced…
- Trial name
- PARADOR (NCT03119623)
- Testing
- sacubitril/valsartan, Enalapril
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Congestive, Dyspnea
Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF
Heart failure (HF) is a disease that is caused by a reduced heart muscle function. Reduced heart muscle function can occur as a consequence of reduced pumping activity from a weak heart muscle or because of a stiff heart muscle.
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00505791
- Testing
- Nesiritide
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Heart Failure With Reduced Ejection Fraction
Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® Software
The goal of this clinical trial investigation with device is to determinate the effectiveness of remote monitoring of patients with heart failure with reduced ejection fraction heart (EFS40%) using Caaring® software.
- Trial name
- (CAARdioRING) (NCT06920160)
- Testing
- software Caaring (remote monitoring app)
- Where
- 2 sites in Spain
- Volunteers
- 196 people
- Sponsor
- Persei Vivarium
Chronic Stable Heart Failure
Qishenyiqi for Ventricular Remodeling After Myocardial Infarction
The effects of Qishenyiqi dripping pill on cardiac remodeling in patients with chronic stable heart failure have not been reported.
- Trial name
- NCT06699407
- Testing
- Qishenyiqi dripping pills
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure With Reduced Ejection Fraction (HFrEF)
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
The primary purpose of the study is to evaluate the safety and efficacy of 2 doses of AC01 compared to placebo over 12 weeks in participants with chronic advanced HFrEF.
- Trial name
- GOAL-HF2 (NCT07584967)
- Testing
- AC01
- Volunteers
- 400 people
- Sponsor
- AnaCardio AB
Pulmonary; Hypertension, Heart Failure
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown…
- Conditions
- Pulmonary; Hypertension, Heart Failure, Preserved Ejection Fraction
- Trial name
- PMED (NCT02980068)
- Testing
- 15N Nitrate, 14N Nitrate
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Heart Failure and Reduced Ejection Fraction, Transitional Care
Effects of a Transitional Care Program on Depression, Self-Efficacy, and Self-Care in Patients With Heart Failure
This randomized controlled trial aims to evaluate the effects of a structured transitional care program on depression, self-efficacy, and self-care behaviors in patients with heart failure.
- Trial name
- NCT07660237
- Testing
- Structured Transitional Care Program, Usual Care
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Chang Gung Memorial Hospital
Heart Failure, Pulmonary Hypertension
Rivet PVS Therapy in Group 2 PH-HFpEF Canada
This clinical investigation is a prospective, multicenter, non-randomized, open-label, Early Feasibility Study to evaluate the safety, performance, and initial clinical efficacy of the Rivet PVS therapy in patients with…
- Trial name
- NCT05332873
- Testing
- Rivet Shunt
- Where
- Canada
- Sponsor
- NXT Biomedical
Heart Failure, Mortality
The Comparative Effectiveness Between ARNI and ACE Inhibitor/ARB Medication in Patient With HFrEF
This study aimed to evaluate the effectiveness, safety, and cost-effectiveness of ARNI and ACEi/ARBs in real-world practice. This study could find out what the unmet medical needs are in real world practice.
- Trial name
- PARADE-HF (NCT05329727)
- Testing
- Angiotensin receptor neprilysin inhibitor (ARNI), Renin-Angiotensin System Inhibitor (RAS inhibitor)
- Where
- South Korea
- Volunteers
- 1,000,000 people
- Sponsor
- Wonju Severance Christian Hospital
Heart Failure With Reduced Ejection Fraction (HFrEF), Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
This retrospective study will take advantage of an existing EU-funded dataset, the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF), which was designed to identify biomarkers related to the response to…
- Trial name
- NCT07470554
- Where
- Italy
- Volunteers
- 4,254 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure With Preserved Ejection Fraction, Hypertension
Clinical Significance and Diagnosis of Sarcopenia in Cardiac Patients
Obesity sarcopenia, characterized by the coexistence of excess fat and muscle mass reduction, may contribute to the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertension, Sarcopenic Obesity
- Trial name
- NCT04175080
- Where
- Poland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
HFrEF - Heart Failure With Reduced Ejection Fraction
Vsling™ III: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
Prospective, multi-center, open-label clinical study of the feasibility and initial safety and performance of the Vsling™ in patients with heart failure (HF) with evidence of reduced left ventricular ejection fraction, associated…
- Trial name
- Vsling III (NCT06002386)
- Testing
- Vsling
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Cardiac Success
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