Clinical trials: Elderly Cancer Patients
Oesophagus Cancer, Elderly Patients
Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Management of elderly patient with cancer is a therapeutic challenge and a public health problem. The mean age of esophageal cancer is 64.5 years and 72.1 years in men and women respectively.
- Trial name
- OSAGE (NCT02735057)
- Testing
- Carboplatin
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Non-Small Cell Lung Cancer
Study of Chemotherapy and PD-1 Inhibitor Combination With Anti-angiogenesis to Treat Elderly Lung Cancer
This single-center, open-label, phaseⅠstudy is to evaluate the efficacy of Tislelizumab in combination with Bevacizumab and Pemetrexed for the first-line treatment of advanced Non-squamous Non-small Cell lung cancer in Elderly…
- Trial name
- NCT05273814
- Testing
- Tislelizumab, Pemetrexed, Bevacizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Esophageal Cancer, Esophageal Neoplasms
Esophageal Cancer Multimodal Prehabilitation Study
The goal of this research study is to investigate the feasibility of implementing a prehabilitation program that aims to improve a patient's physical, nutritional, and sleep health before surgery in an older, at-risk group with…
- Trial name
- NCT06027515
- Testing
- Prehabilitation Program
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Hodgkin Lymphoma
A Multi-centre Study of MBVD in Elderly and/or Cardiopathic Patients Affected by Hodgkin's Lymphoma (HL)
The study has the purpose to evaluate in elderly and/or cardiopathic HL patients, the cardiologic toxicity of the MBVD regimen, where liposomal doxorubicin (Myocet®) is substituted for doxorubicin in the conventional ABVD regimen.
- Trial name
- HD0803 (NCT01523847)
- Testing
- MBVD (Myocet+BVD)
- Where
- 26 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Diffuse Large B-Cell Lymphoma, Lymphoma, Diffuse Large-Cell
Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma
The purpose of this research study is to learn about the safety of the treatment with a combination of bendamustine and rituximab and to find out what effects, both good and bad this treatment has on DLBCL.
- Conditions
- Diffuse Large B-Cell Lymphoma, Lymphoma, Diffuse Large-Cell, Diffuse Large-Cell Lymphoma, Lymphoma
- Trial name
- NCT01234467
- Testing
- Bendamustine, Rituximab
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diffuse Large B-Cell Lymphoma
Study of Bendamustine and Ofatumumab in Elderly Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Who Are Poor Candidates for R-CHOP Chemotherapy
This is a single-arm, Phase II study designed to enroll and treat up to 64 patients. All patients in this study will receive ofatumumab and bendamustine as an IV infusion for 6 cycles (a cycle is defined as 21 days in length).
- Trial name
- NCT01626352
- Testing
- Bendamustine, Ofatumumab
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- SCRI Development Innovations, LLC
Plasma Cell Myeloma
Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
This trial studies how well exercise prescription works in improving quality of life in elderly patients with multiple myeloma. Engaging and adhering to an exercise program may improve functional status and quality of life and…
- Trial name
- NCT04100044
- Testing
- Exercise Counseling, Exercise Intervention, Questionnaire administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Jefferson University
Advanced Gastric Cancer
Laparoscopic Versus Open Gastrectomy for Elderly Local Advanced Gastric Cancer Patients
Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing.
- Trial name
- NCT03564834
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University
Nutrition Related Cancer, Aging
Effects of Chocolate Consumption in Elderly Patients With Cancer in Palliative Care
Elderly patients with advanced cancer stage constitute an important demand for palliative care, a scenario in which metabolic and nutritional status changes may be present.
- Trial name
- NCT04367493
- Testing
- Chocolate
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Colorectal Neoplasms
Study of Andrographolides With or Without Capecitabine to Treat Colorectal Cancer
The purpose of this study is to determine the efficacy and safety of Andrographolides combined with Capecitabine in treatment of elderly patients with locally advanced or recurrent or metastasis inoperable colorectal cancer
- Trial name
- AGCRC-013 (NCT01993472)
- Testing
- Andrographolides, Capecitabine
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Gu Yanhong
Diffuse Large B Cell Lymphoma (DLBCL)
Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly Patients With Diffuse Large B-Cell Lymphoma
This single-arm, interventional phase 2 study is designed to evaluate whether the inclusion of mosunetuzumab subcutaneous and polatuzumab vedotin (Mosun-Pola) to a split-dose CHP chemotherapy backbone will improve outcomes for…
- Trial name
- NCT06594939
- Testing
- Polatuzumab Vedotin, Mosunetuzumab, Cyclophosphamide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Medical College of Wisconsin
Diffuse Large B-cell Lymphoma
Trial of R-GemOx Regimen in Previously Untreated Elderly Patients With DLBCL.
The purpose of this study is to investigate efficacy and safety of GemOx(Gemcitabine and Oxaliplatin) combination with rituximab(R) as first-line treatment of elderly patients with DLBCL
- Trial name
- NCT01670370
- Testing
- R-GemOx
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Leukemia
AT9283 in Treating Young Patients With Relapsed or Refractory Acute Leukemia
RATIONALE: AT9283 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I/IIa clinical trial is studying the side effects and best dose of AT9283 in treating young…
- Trial name
- NCT01431664
- Testing
- multikinase inhibitor AT9283, laboratory biomarker analysis, pharmacological study
- Where
- 5 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Cancer Research UK
Diffuse Large B Cell Lymphoma
Prospective Clinical Study of ZPR Regimen in Elderly Treatment-naive Diffuse Large B-cell Lymphoma
This is a prospective, single-arm, single-center clinical study. This clinical study aims to explore the efficacy and safety of the ZPR（Zanubrutinib, Polatuzumab vedotin and Rituximab）regimen in elderly patients with…
- Trial name
- NCT05940064
- Testing
- Zanubrutinib, Polatuzumab Vedotin, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peng Liu
Leukemia, Myelomonocytic, Acute
Umbilical Cord Blood Transfusion in Consolidation Therapy of Elderly Patients With Acute Myeloid Leukemia
After complete remission, elderly AML patients cannot tolerate hematopoietic stem cell transplantation and standard-dose consolidation chemotherapy, and the 5-year survival rate is around 10%.
- Trial name
- NCT04687657
- Testing
- umbilical cord blood
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diffuse Large B-Cell Lymphoma
Study to Evaluate the Efficacy and Safety of Subsequent Treatment With the Zevalin (Ibritumomab Tiuxetan) in Elderly (More Than 60 Years) Patients With Diffuse Large B Cell Lymphoma After 4 Cycles of CHOP21-Rituximab (CHOP21-R) Therapy
Study phase: Phase II Investigational product, dosage, and route of administration: Ibritumomab tiuxetan ("Zevalin) is composed of a murine IgG1 monoclonal antibody (ibritumomab) covalently bound to the chelating agent tiuxetan.
- Trial name
- CHOP21+R-Z (NCT00850512)
- Testing
- CHOP21-R, Zevalin
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- University of Bologna
Colorectal Cancer
Study to Evaluate the Use of Capecitabine in Monotherapy and in Combination With Oxaliplatin in Elderly Patients as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer.
All patients with locally advanced colorectal cancer after radical surgical intervention who have not previously received systemic antitumor treatment will be randomized into two groups receiving fluoropyrimidines in mono-regimen…
- Trial name
- AHTCRR-1 (NCT06888843)
- Testing
- Capecitabine, Oxaliplatin
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Nizhny Novgorod Regional Clinical Oncology Center
Endometrial Cancer
A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Endometrial (uterine) cancer affects over 40,000 women each year in the United States. At this time there are no medications to prevent endometrial cancer. Women who are heavy are at increased risk of this cancer.
- Trial name
- NCT00161226
- Testing
- Levonorgestrel intrauterine system
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cancer, Elderly Patients
Modification of the Quality of Life Based on Objective Geriatric Tests
The analysis of this study will achieve an improvement in the management of patients over 70 years with adaptation of chemotherapy regimens after analysis of the subject and its psychosocial environment.
- Trial name
- MEGERIA (NCT02873533)
- Testing
- geriatric care and longitudinal follow up
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Antoine Lacassagne
Pancreatic Cancer, Cholangiocarcinoma
Oral Protein Supplements for Nutritional and Quality of Life Improvement After Pancreatic Resection in Elderly Patients
This study investigates the effects of oral protein supplements on the nutritional status and quality of life in elderly patients following standard pancreatic resection.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Intraductal Papillary Mucinous Neoplasm, Neuroendocrine Tumor
- Trial name
- NCT06570174
- Testing
- oral protein supplements
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
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