Clinical trials: Elderly Cancer Patients
Cancer, Rectal
Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer
This study will help determine if a short course of radiation therapy is effective to treat rectal cancer in older patients. A shorter course of radiation treatment may be better tolerated than a longer course or surgery for the…
- Trial name
- NCT04139967
- Testing
- Short course radiation therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Follicular Lymphoma
BRIEF Bendamustine and Rituximab In Elderly Follicular
The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular…
- Trial name
- BRIEF (NCT01313611)
- Testing
- Rituximab + bendamustine
- Where
- 117 sites in Belgium, France
- Volunteers
- 62 people
- Sponsor
- The Lymphoma Academic Research Organisation
Breast Cancer, Recurrent Breast Cancer
A Study of Diffusing Alpha Radiation Therapy for Patients With Breast Carcinoma in Frail or Elderly Patients.
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for the treatment of newly diagnosed or Recurrent Breast Carcinoma in frail or elderly patients.
- Conditions
- Breast Cancer, Recurrent Breast Cancer, Breast Carcinoma
- Trial name
- NCT06202118
- Testing
- Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Alpha Tau Medical LTD.
Postoperative Delirium, Postoperative Neurocognitive Disorder
Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms
This is a prospective cohort study to explore the differences of serum indicators between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative…
- Conditions
- Postoperative Delirium, Postoperative Neurocognitive Disorder, Gastrointestinal Surgery
- Trial name
- NCT06466096
- Testing
- no intervention
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Colorectal Cancer
Study of First-line Single-agent Panitumumab in Frail Elderly Patients With Advanced Wild Type K-RAS Colorectal Cancer
The purpose of the study is to evaluate the efficacy and safety of first-line single-agent panitumumab in frail elderly patients with advanced Wild Type K-RAS colorectal cancer
- Trial name
- FRAIL (NCT01126112)
- Testing
- Panitumumab
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Acute Myeloid Leukemia (AML)
"InDACtion" vs "3+7" Induction in AML
Older patients with acute myeloid leukemia (AML) have a small (< 10%) chance of long-term survival. Despite the treatment of elderly AML patients with intensive chemotherapy, the survival has not been improved during the last…
- Trial name
- NCT02172872
- Testing
- standard combination chemotherapy, decitabine
- Where
- 53 sites in Belgium, Bulgaria and 7 more
- Volunteers
- 606 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Non-Small Cell Lung Cancer
OSI-774 (Erlotinib, Tarceva) in Elderly Patients
The purpose of this research study is to determine if OSI-774 (Tarceva) is effective in the treatment of non-small cell lung cancer and to further study its side effects.
- Trial name
- NCT00200395
- Testing
- Tarceva
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Montefiore Medical Center
Kidney Cancer, Renal Cell Cancer
Cabozantinib and Nivolumab Among Older Patients With Renal Cell Carcinoma
The goal of the study is to describe real-life use and exposition to nivolumab-cabozantinib among older patients with metastatic clear-cell renal cell cancer
- Trial name
- CABOLD (NCT06934057)
- Testing
- Nivolumab, Cabozantinib
- Where
- 7 sites in France
- Volunteers
- 50 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Multiple Myeloma
Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy
This is a Phase 3, randomized (study drug assigned by chance), open-label (participants and researchers are aware about the treatment, participants are receiving), active-controlled (study in which the experimental treatment or…
- Trial name
- IFM2017_03 (NCT03993912)
- Testing
- Daratumumab SC in combination with Lenalidomide, Lenalidomide PO (25mg), Dexamethasone PO (20mg): days 1, 8, 15, 22 of each 28-day cycle, until progression
- Where
- 23 sites in France
- Volunteers
- 294 people
- Sponsor
- University Hospital, Lille
Elderly Patients, Metastatic Lung Cancer
Single-drug Chemotherapy Plus Immunotherapy in Metastatic Non-small Cell Lung Cancer Elderly Patients
Lung cancer is the cancer with the highest morbidity and mortality among men in the world. The proportion of elderly lung cancer patients in the global lung cancer population is steadily increasing, at the same time, it is also…
- Trial name
- NCT06032052
- Testing
- Single drug chemotherapy plus immunotherapy
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Hubei Cancer Hospital
Esophageal Cancer, Esophageal Neoplasms
Esophageal Cancer Multimodal Prehabilitation Study
The goal of this research study is to investigate the feasibility of implementing a prehabilitation program that aims to improve a patient's physical, nutritional, and sleep health before surgery in an older, at-risk group with…
- Trial name
- NCT06027515
- Testing
- Prehabilitation Program
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Diffuse Large B Cell Lymphoma
Zanubrutinib, Lenalidomide and Rituximab (ZR2) in Elderly Treatment-naive Patients With Diffuse Large B-cell Lymphoma (DLBCL)
This is a prospective, single-center, open-label, single-arm clinical study designed to evaluate the efficacy and safety of the Zanubrutinib, Lenalidomide and Rituximab (ZR2) regimen in elderly treatment-naive patient with…
- Trial name
- NCT04460248
- Testing
- Zanubrutinib, Lenalidomide and Rituximab (ZR2)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Untreated CD20-positive Large B-cell Lymphoma
Study of R-ACVBP Regimen Supported by Pegfilgrastim in High-Risk Diffuse Large B-Cell Lymphoma
Evaluation of the efficacy of a single injection of Pegfilgrastim (6mg) administered at day 3 of each cycle of R-ACVBP regimen during 4 cycles in patients with CD20+ diffuse large B-cell lymphoma presenting at least 2 adverse…
- Trial name
- NCT00169143
- Testing
- Rituximab + ACVBP regimen plus Pegfilgrastim, Autologous stem cell transplant
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- Lymphoma Study Association
Nasopharyngeal Carcinoma
Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
- Trial name
- NCT03058432
- Testing
- Radiotherapy alone, Concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Zhejiang Cancer Hospital
Colorectal Cancer
S-1/Leucovorin (SL) Versus sLV5FU2 as the First-line Treatment for Elderly Patients With Colorectal Cancer
This phase II trial on the assumption that S-1 combined with Leucovorin may have better efficacy and safety than simplified 5-FU/LV infusion therapy in elderly patients with advanced colorectal cancer.
- Trial name
- NCT01193452
- Testing
- S-1, Leucovorin, leucovorin, 5-fluorouracil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Non-squamous Non-small-cell Lung Cancer, Cancer, Lung
Pembrolizumab Plus Pemetrexed for Elderly Patients With Non-Sq NSCLC With PD-L1 < 50%: CJLSG1901
To evaluate the efficacy and safety of Pembrolizumab + Pemetrexed in elderly patients with non-squamous non-small cell lung cancer with Programmed cell death (PD) -ligand1 (L1) tumor proportion score (TPS) of less than 50%.
- Trial name
- NCT04396457
- Testing
- Pembrolizumab, Pemetrexed
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- National Hospital Organization Nagoya Medical Center
Geriatric Disorder, Cancer
Adaptation of the STEPPING ON Fall Prevention Program for Older Adults Receiving Cancer Therapy
Chronic disease self-management is the ability of the individual, in conjunction with family, community and healthcare professionals to manage symptoms, treatments, lifestyle changes and psychosocial, cultural and spiritual…
- Conditions
- Geriatric Disorder, Cancer, Patient Fall
- Trial name
- NCT02737839
- Testing
- Stepping On Education Program, Home visit, Patient Questionnaire
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Nutrition and Exercise Program for Elderly Colorectal Cancer Patients
The goal of this interventional study is to evaluate the effect of mobile health intervention on frailty, physical fitness, physical activity, and nutritional status of elderly patients with colorectal cancer.
- Trial name
- NCT06502275
- Testing
- Mobile Health Management Frailty Care Program
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia
Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. Phase II trial to study the effectiveness of tipifarnib in treating older patients who have previously untreated acute myeloid…
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Erythroid Leukemia (M6)
- Trial name
- NCT00027872
- Testing
- tipifarnib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- National Cancer Institute (NCI)
Breast Neoplasms, Breast Self-Examination
Health Belief Model-Based Survey on Breast Self-Examination Awareness and Practice Among Community-Dwelling Middle-Aged and Older Women
This observational study aims to evaluate the current status of breast self-examination (BSE) practices and related influencing factors among middle-aged and older women in urban communities, using the Health Belief Model (HBM)…
- Conditions
- Breast Neoplasms, Breast Self-Examination, Cancer Screening, Health Belief Model
- Trial name
- HBM-BSE (NCT07149636)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
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