Clinical trials: Elderly Cancer Patients
Carcinoma, Non-Small-Cell Lung
An Dose Escalation Trial of Oral BIBF 1120 in Combination With Intravenous Vinorelbine in Elderly Patients With Advanced Non Small Lung Cell Cancer - Stage IV (VENUS-1)
To investigate the maximum tolerated dose of BIBF 1120, safety and pharmacokinetics in escalating doses administered with Vinorelbine i.v. in elderly patients with advanced Non-Small Lung Cancer (Stage IV).
- Trial name
- VENUS-1 (NCT01684111)
- Testing
- BIBF 1120, Vinorelbine
- Where
- 4 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Aktion Bronchialkarzinom e.V.
Diffuse Large B Cell Lymphoma
Polatuzumab, Rituximab and Orelabrutinib Combination Regimen (PRO) in the Treatment of Elderly Frail Patients with Treatment-naive Non-GCB DLBCL
This prospective, single-arm, multicenter clinical study aims to enroll 30 frail elderly patients with Non-GCB DLBCL. This study is to evaluate the preliminary efficacy and safety of the combination of Polatuzumab, Rituximab, and…
- Trial name
- NCT06530511
- Testing
- Polatuzumab vedotin, Rituximab, Orelabrutinib
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
Breast Cancer
FACILE: FeAsibility of First-line RiboCIclib in OLdEr Patients with Advanced Breast Cancer
Phase II, multicenter, single arm trial to assess the feasibility of first line ribociclib in combination with a non steroidal aromatase inhibitor in women or men aged 70 years-old or older, with hormone receptor positive/HER2…
- Trial name
- FACILE (NCT03944434)
- Testing
- Ribociclib, Aromatase Inhibitors, non steroideal, LHRH agonist
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione Sandro Pitigliani
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
NSCLC Stage IV, NSCLC, Stage III
Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
ROS1 rearrangements are rare, accounting for only 1-2% of NSCLC cases, but have been associated with response to ROS1 inhibitors, such as crizotinib and entrectinib.
- Trial name
- REPOROS (NCT06552234)
- Testing
- Repotrectinib
- Where
- 20 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Mantle Cell Lymphoma
Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma
This phase II trial studies the side effects of acalabrutinib and rituximab and its effect in treating patients with previously untreated mantle cell lymphoma.
- Trial name
- NCT04765111
- Testing
- Acalabrutinib, Rituximab
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- M.D. Anderson Cancer Center
HR+HER2- Advanced Breast Cancer
A Prospective Non-interventional Study to Evaluate Clinical Outcomes of Ribociclib Combined With Endocrine Therapy in Elderly Patients With HR+HER2 - Advanced Breast Cancer in Routine Clinical Practice in Russian Federation
This is а prospective, non-interventional, primary data collection study to evaluate the effectiveness, safety and quality of life in older patients (≥65 years) with HR+HER2- advanced breast cancer receiving ribociclib with ET in…
- Trial name
- PARFENOPA (NCT06625333)
- Where
- 20 sites in Russia
- Volunteers
- 329 people
- Sponsor
- Novartis Pharmaceuticals
Metastatic Colorectal Cancer
Phase II Study to Evaluate Safety and Efficacy of Cetuximab in Combination With XELOX for 12 Weeks Followed by Maintenance Treatment With Cetuximab Plus Capecitabine as First-line Treatment in Elderly Patients With Metastatic Colorectal Cancer.
The purpose of this study is to determine confirmed objective response rate to combination therapy with cetuximab plus XELOX for 4 cycles followed by maintenance treatment with cetuximab plus capecitabine as first line treatment…
- Trial name
- NCT00531115
- Testing
- cetuximab 5mg/ml
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Pancreatic Cancer, Surgery
Quality of Life in Elderly Patients After Pancreatic Cancer Surgery
Pancreatic cancer mainly affects the elderly, with over 85% of patients diagnosed after the age of 60 and over half after the age of 70.
- Conditions
- Pancreatic Cancer, Surgery, Elderly
- Trial name
- ADL_DPC_PA (NCT06079229)
- Testing
- Phone call
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Advanced Cancer, Older Adults (65 Years and Older)
A Pilot Randomized Controlled Trial of a Social Network Intervention
This is a pilot randomized controlled trial to assess the feasibility, acceptability, appropriateness, and structure of the SONATA intervention.
- Conditions
- Advanced Cancer, Older Adults (65 Years and Older), Social Networks
- Trial name
- SONATA 2 (NCT07393529)
- Testing
- SONATA
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Breast Cancer
Addtional Effect of Hyperbaric Oxygen to Programmed Physical Activity on Musckoloskeletal Pain in Breast Cancer Elderly
patienst who survived from breast cancer are prescribed long administraion of aromatase inhbitors.. these inhibitors usually induce musckloskeletal pains.
- Trial name
- NCT07662629
- Testing
- hyperbaric therapy and exercise, exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cancer, Cancer-related Problem/Condition
Cancer and Aging Research Group (CARG) Chemotherapy Toxicity Risk Scores in Older Adults With Cancer in China
The goal of this observational study is to learn about the impact of chemotherapy-related toxicity on older cancer patients in China.
- Trial name
- NCT06717178
- Testing
- Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Pancreatic Neoplasms
Onco-geriatric Database of Patients With Pancreatic Cancer
This data base has been set in order to gather oncogeriatric information from elderly patients with pancreatic cancer who underwent an oncogeriatric evaluation.
- Trial name
- NCT02858141
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Paoli-Calmettes
Head Neck Cancer Squamous Cell Recurrent
Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer
To test whether cetuximab improves efficacy/tolerance as compared to methotrexate in first line treatment of unfit patients ³ 70 years old with recurrent and /or metastatic HNSCC. Efficacy assessed by failure free survival
- Trial name
- ELAN-UNFIT (NCT01884623)
- Testing
- Cetuximab, Methotrexate
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cancer
Remote Monitoring for Ambulatory Care of Elderly Patients With Cancer
Monocentric, prospective cohort pilot study evaluating the feasibility of a online remote monitoring tool during the care of patients over 65 years of age being medically treated for cancer.
- Trial name
- TS-PAC (NCT04913259)
- Testing
- Remote monitoring
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Institut Bergonié
Adenocarcinoma Pancreas
Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients
The GrantPax study is a multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/- nab-paclitaxel in elderly pancreatic cancer patients.
- Trial name
- GrantPax (NCT02812992)
- Testing
- Nab-paclitaxel, Gemcitabine, Best Supportive Care
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- AIO-Studien-gGmbH
Non-Small Cell Lung Cancer
Erlotinib Versus Carboplatin/Vinorelbine in Elderly Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
60% of all malignant diseases occur in patients who are 65 years or older. For these patients, aggressive treatments are often not suitable due to reduced life-expectancy, reduced general condition, comorbidities, and reduced…
- Trial name
- TIE (NCT00678964)
- Testing
- Erlotinib, Vinorelbine and Carboplatin
- Where
- 40 sites in Germany
- Volunteers
- 260 people
- Sponsor
- LungenClinic Grosshansdorf
Acute Myeloid Leukemia
Decitabine Combined With Unrelated Cord Blood Transplantation for Elderly Patients With AML
Acute myeloid leukemia (AML) is a clonal disease caused by genetic mutations in Hematopoietic stem progenitor cells. Unfortunately, advanced age (>60 years old) is considered to be one of the most important adverse prognostic…
- Trial name
- NCT03913312
- Testing
- Unrelated cord blood
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Tumor, Health Services Research
Care Pathways and Disparities in Care for Older Patients With Cancer: Typology, Determinants and Effect on Prognosis ( PASSAGE )
More than half of new cases of cancer in Europe in 2022 occurred in people aged over 70. In addition to cancer, the majority of older people have one or more illnesses that may interact with the treatment decision, cancer…
- Conditions
- Tumor, Health Services Research, Causality, Geriatric Assessment
- Trial name
- PASSAGE (NCT07092800)
- Where
- France
- Volunteers
- 75,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
DLBCL, Diffuse Large B-Cell Lymphoma
Clinical Study of HiR+X Therapy for Newly Diagnosed Elderly Patients With DLBCL Intolerant to Chemotherapy
To explore the application of HiR (Zebtorizumab, Lenalidomide) + X (targeted drug) guided by NGS molecular typing, the aim is to assess the therapeutic efficacy and safety in newly diagnosed unfit or frail elderly patients with…
- Trial name
- HiR+X (NCT06758037)
- Testing
- Drug therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Ningbo University
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