Clinical trials: Elderly Cancer Patients
Precursor Cell Lymphoblastic Leukemia-lymphoma
Intravenous Ixazomib in Pediatric Participants With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy)
The purpose of this study is to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D), safety and toxicity, and pharmacokinetics (PK) of ixazomib administered intravenously in combination with…
- Trial name
- NCT03888534
- Testing
- Ixazomib
- Where
- 7 sites in United States, Spain
- Sponsor
- Millennium Pharmaceuticals, Inc.
Acute Myeloid Leukemia
Maintenance Therapy in Acute Myeloid Leukemia (AML) Patients
The purpose of this study is to determine if Revlimid will help maintain patients with acute myeloid leukemia in remission.
- Trial name
- NCT00957385
- Testing
- Revlimid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Elderly Patients, Solid Organ Cancer
Epidural Anesthesia and Long-term Outcomes in Elderly Patients After Surgery
Surgical resection is one of the most important treatments for solid organ cancer. Whereas cancer recurrence and/or metastasis are the major reasons of treatment failure.
- Conditions
- Elderly Patients, Solid Organ Cancer, Surgical Resection, Epidural Anesthesia
- Trial name
- NCT03335826
- Testing
- Combined epidural-general anesthesia, General anesthesia
- Where
- 5 sites in China
- Volunteers
- 1,802 people
- Sponsor
- Peking University First Hospital
Non Small Cell Lung Cancer
Elderly Independent Patients With Non Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine duration before progression of first-line treatment chemotherapy following erlotinib in second-line comparing erlotinib in first-line following chemotherapy in second-line in old patients…
- Trial name
- NCT00418704
- Testing
- Erlotinib, taxotere
- Where
- 22 sites in France
- Volunteers
- 100 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Breast Cancer
S0029 Docetaxel in Treating Older Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of docetaxel in treating older women who have metastatic…
- Trial name
- NCT00025493
- Testing
- docetaxel
- Volunteers
- 27 people
- Sponsor
- SWOG Cancer Research Network
Rectal Cancer
Laparoscopic Intersphincteric Resection in Elderly Patients
The aim of the present study is to assess if it is possible to offer intersphincteric rectal resection (IRR) to selected patients older than 70 years affected by ultra-low rectal cancer.
- Trial name
- NCT04673526
- Testing
- Laparoscopic intersphincteric resection, Laparoscopic abdomino-perineal procedures
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ASL Verbano Cusio Ossola
Colorectal Cancer
Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer
Fried Scale and its related scales were used to analyze the status and risk factors of preoperative frailty in elderly patients with colorectal cancer.
- Trial name
- NCT05879861
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Zunyi Medical College
Prostatic Cancer
Effect of Adding Sufentanil to Epidural Ropivacaine on Perioperative Metabolic and Stress Responses in Combined General/Epidural Anaesthesia for Geriatric Radical Retropubic Prostatectomy
The purpose of this study is to compare metabolic and stress responses in combined general/epidural anesthesia in geriatric cancer patients.
- Trial name
- NCT01086956
- Testing
- epidural infusion of saline, ropivecaine, or ropivacaine and sufentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Locally Advanced Cervical Carcinoma
Decision Aid for Chemotherapy in Cisplatin-Intolerant Patients With Locally Advanced Cervical Cancer
The goal of this clinical trial is to investigate the utility and effectiveness of a decision aid in cisplatin-intolerant patients with locally advanced cervical cancer. The main questions it aims to answer are: 1.
- Trial name
- CECIL (NCT05701735)
- Testing
- CECIL Patient Decision Aid
- Where
- 3 sites in Philippines
- Volunteers
- 45 people
- Sponsor
- University of Santo Tomas Hospital, Philippines
Breast Cancer, Cognitive/Functional Effects
Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly Diagnosed Breast Cancer or Colon Cancer
RATIONALE: Gathering health information from older patients undergoing chemotherapy may help doctors plan better treatment and improve the quality of life for these patients.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00873600
- Testing
- chemotherapy, medical chart review, questionnaire administration
- Sponsor
- Case Comprehensive Cancer Center
Esophagus Squamous Cell Carcinoma
Raltitrexed Concurrent With Radiotherapy for Elderly Chinese Patients With Squamous Cell Carcinoma of Esophagus
Concurrent chemoradiotherapy is one of the curative options for esophageal squamous cell carcinoma. We evaluated the efficacy and toxicity of raltitrexed with concurrent radiotherapy in elderly patients with esophageal cancer.
- Trial name
- NCT03585530
- Testing
- raltitrexed
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Huai'an First People's Hospital
Lymphoma
Pegfilgrastim and Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Aggressive B-Cell Non-Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, and vincristine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00726700
- Testing
- pegfilgrastim, rituximab, cyclophosphamide
- Volunteers
- 109 people
- Sponsor
- Universität des Saarlandes
Non-small Cell Lung Cancer
Study of Gleevec and Weekly Paclitaxel in Patients Aged 70 or Older With Advanced Non-small Cell Lung Cancer
This study will evaluate the clinical efficacy of combining Gleevec (imatinib mesylate), a PDGFR antagonist, with front-line, single-agent paclitaxel in a cohort of elderly patients with advanced, non-small cell lung cancer.
- Trial name
- 6137p (NCT01011075)
- Testing
- Imatinib mesylate, Paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- New Mexico Cancer Research Alliance
Colorectal Cancer Metastatic
Radioembolization in Elderly/ Fragile Patients With mCRC
Radioembolization (RE) is a minimally invasive treatment with administration of radioactive microspheres into the hepatic artery via a microcatheter.
- Trial name
- CAIRO7 (NCT05092880)
- Testing
- radioembolization, Standard of care first-line systemic therapy
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- UMC Utrecht
Esophageal Cancer
Gefitinib Combined With Radiotherapy in Elderly Patients With Esophageal Cancer
Elderly patients with esophageal cancer will receive thoracic radiation therapy 54-60Gy over 30 fractions, and concurrent with Gefitinib.
- Trial name
- NCT01291823
- Testing
- gefitinib, Thoracic radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhejiang Cancer Hospital
Multiple Myeloma
Velcade, Melphalan, Prednisone And Thalidomide Versus Velcade, Melphalan, Prednisone in Multiple Myeloma Patients
The proposed study will evaluate whether the combination of VELCADE, Thalidomide , Melphalan and Prednisone (V-MPT), as induction treatment for newly diagnosed elderly MM patients, improves outcomes compared to the combination…
- Trial name
- NCT01063179
- Testing
- Bortezomib, Melphalan, Prednisone, Thalidomide, Bortezomib, Melphalan, Prednisone
- Where
- Italy
- Volunteers
- 511 people
- Sponsor
- Fondazione EMN Italy Onlus
Multiple Myeloma in Relapse
Subcutaneous Talquetamab in Elderly Patients With Multiple Myeloma in Early Relapse
Induction therapy approaches in recent years have evolved, now utilizing triple or quadruple drug regimens in the majority of patients.
- Trial name
- NCT06827860
- Testing
- Talquetamab, Daratumumab
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Larysa Sanchez
Hematological Malignancies
Nonmyeloablative Stem Cell Transplant in Elderly
The study aimed to evaluate the efficacy of a nonmyeloablative conditioning consisting of fludarabine and total body irradiation in patients older than 60 years of age
- Trial name
- NCT00382759
- Testing
- stem cell transplant
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Confort, Older Adults With Cancer
Enhancing Patient Experience in Geriatric Oncology
Approximately 60% of new cancer diagnoses and 70% of cancer-related deaths occur in adults aged 65 years and older, a population frequently affected by multimorbidity, frailty, sensory impairment, and treatment-related symptom…
- Trial name
- NCT07671586
- Testing
- Comfort menu and cart implemented
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- Hospital Sirio-Libanes
Multiple Myeloma in Older Patients
Vulnerability and Therapeutic Changes in Older Patients With Multiple Myeloma.
The aim of this study is to determine whether the presence of vulnerability detected by geriatricians is associated with treatment discontinuation in older patient.
- Trial name
- MYELOME-PA (NCT02063113)
- Testing
- Vulnerability and therapeutic changes in older patients with multiple myeloma.
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Nantes University Hospital
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