Clinical trials: Elderly Cancer Patients
Soft Tissue Sarcoma
A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.
This is a phase II, multicenter, non-randomized study. The main objective is to evaluate the treatment with hypofractionated radiation therapy in neo-adjuvant situations on wound healing in a population of aged patients (≥ 70…
- Trial name
- HYPOSARC (NCT06022159)
- Testing
- Hypofractionated Radiation Therapy, Conservative treatment
- Where
- 11 sites in France
- Volunteers
- 48 people
- Sponsor
- Institut Claudius Regaud
Multiple Myeloma
Study to Demonstrate Clinical Benefit of Lenalidomide and Dexamethasone
Recent prospective multicenter phase II study assessed the efficacy and tolerability of lower dose lenalidomide (15mg) and dexamethasone (20mg) in frail patients with relapsed or refractory MM.
- Trial name
- LENDER (NCT03809780)
- Testing
- Lenalidomide, Dexamethasone
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Kosin University Gospel Hospital
Cognitive Decline, Urinary Bladder Cancer
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often…
- Conditions
- Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker
- Trial name
- NCT07165236
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- Osijek University Hospital
Care Delivery, Geriatrics
Understanding the Preferences and Views of Older Adults on the Use of Geriatric and Objective Functional Assessments for Cancer Treatment Planning.
This Interventional clinical study aims to explore how receiving information about their health and physical abilities affects the treatment decisions of older adults.
- Conditions
- Care Delivery, Geriatrics, Geriatric Assessment
- Trial name
- NCT06652347
- Testing
- Cancer care delivery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Progression Free Survival(PFS)
Safety and Efficacy Analysis of Oral Etoposide Combined With Anlotinib and Envafolimab in First-line Treatment of Elderly Patients With Small Cell Lung Cancer/ Open-label, Single-arm, Exploratory Phase II Clinical Study
This study aims to explore the safety and efficacy of etoposide capsules combined with Anlotinib and Envafolimab in elderly patients with extensive small cell lung cancer.This is a single-center, single-arm exploratory clinical…
- Trial name
- NCT05685550
- Testing
- Toposide capsules combined with Anlotinib and Envafolimab group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer, Lung Cancer
Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel
This study is to explore the feasibility of an alternative dose of dexamethasone pre-medication in older breast and lung cancer patients who are receiving weekly docetaxel chemotherapy.
- Trial name
- NCT00215748
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Geriatric Oncology Consortium
Breast Cancer
Paclitaxel Plus Bevacizumab for Older Patients With Breast Cancer
This study will evaluate the efficacy, safety and effect on quality of life of weekly paclitaxel plus bevacizumab as first line treatment in elderly patients (≥ 70 years old) with metastatic breast cancer.
- Trial name
- NCT01120158
- Testing
- Bevacizumab, Paclitaxel
- Where
- 11 sites in Greece
- Volunteers
- 46 people
- Sponsor
- Hellenic Oncology Research Group
Stage IV, NSCLC, Lung Neoplasms
The EPIC Trial The Elderly Patient Individualized Chemotherapy Trial
This is a randomized phase III trial that will randomize elderly patients(70 years of age and older) who are not considered eligible for standard doublet or triplet regimens.
- Conditions
- Stage IV, NSCLC, Lung Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic
- Trial name
- EPIC (NCT03402048)
- Testing
- Carboplatin, Gemcitabine, Pemetrexed
- Where
- 28 sites in Italy
- Volunteers
- 567 people
- Sponsor
- University of Turin, Italy
Carcinoma, Non-Small-Cell Lung, ErbB Receptors
Afatinib Treatment for Patients With EGFR Mutation Positive NSCLC Who Are Age 70 or Older
Continuous treatment until progression or occurence of intolerable Adverse Event (AE) or end of trial. The end of trial is one year after the last patient has entered the study.
- Trial name
- NCT02514174
- Testing
- Afatinib
- Where
- 10 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boehringer Ingelheim
Acute Myeloblastic Leukemia
Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients
The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.
- Trial name
- LAMME (NCT07250217)
- Testing
- Epigenetic markers
- Where
- 2 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Self Geriatric Assessment Measure (SGAM)
LCI-GER-NOS-TAB-001: Tablet for Geriatric Assessment
The Self Geriatric Assessment Measure [SGAM] is based on a standard diagnostic tool used to evaluate geriatric cancer patients in order to determine the appropriateness of cancer directed therapy at LCI.
- Trial name
- NCT03419468
- Testing
- Self Geriatric Assessment Measure (SGAM)
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Wake Forest University Health Sciences
Elderly Patient, Cancer
the Impact of Occupational Therapy : a Multicenter Randomized Controlled Trial
The purpose of this randomized controlled superiority trial is to evaluate the impact of occupational therapy assessment and intervention on the quality of life of elderly cancer patients.
- Conditions
- Elderly Patient, Cancer, Quality of Life
- Trial name
- OCEAN-OT (NCT05878782)
- Testing
- MCRO+Occupational therapy, MCRO without intervention
- Volunteers
- 232 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Small Cell Lung Cancer Extensive Stage, ELDERLY PEOPLE
Etoposide Plus Benmelstobart Followed by Maintenance Therapy of Benmelstobart Plus Anlotinib in First-line Treatment of Elderly Patients with Extensive Stage Small Cell Lung Cancer: a Single-arm, Prospective Trial
This is a prospective, single-arm clinical study to evaluate the efficacy and safety of etoposide in combination with bemosubezumab and sequential Benmelstobart in combination with Anlotinib as first-line treatment for elderly…
- Trial name
- NCT06825208
- Volunteers
- 29 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cancer
Study of Elderly Patients With Cancer and Seen in Consultation of Geriatric Oncology in the Nord Pas-de-Calais (CONSOG).
The aim of this study is to establish a common geriatric oncology medical database. The patients concerned are the patients having benefited from a geriatric oncology consultation in one of the participating centres.
- Trial name
- CONSOG (NCT02501174)
- Where
- 15 sites in France
- Volunteers
- 2,914 people
- Sponsor
- Centre Oscar Lambret
Metastatic Breast Cancer, Advanced Breast Cancer
Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients
IMPORTANT study is a multicenter, open-label, prospective, randomized-controlled, non-inferiority trial with a pragmatic approach involving older patients (≥ 70 years old) with advanced hormone receptor (HR)-positive/human…
- Conditions
- Metastatic Breast Cancer, Advanced Breast Cancer, Quality of Life, Toxicity
- Trial name
- IMPORTANT (NCT06044623)
- Testing
- CDK 4/6 inhibitors, Endocrine therapy
- Where
- 12 sites in Finland, Greece and 4 more
- Volunteers
- 495 people
- Sponsor
- Region Örebro County
Postoperative Cognitive Dysfunction
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor
Postoperative cognitive dysfunction(POCD). is a central nervous system complication in cancer patients with a 8.9-46.1% incidence.
- Trial name
- TEAS (NCT05482477)
- Testing
- Transcutaneous acupoint electrical stimulation
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Acute Lymphoblastic Leukemia
Liposomal Anthracyclin in the Treatment of Elderly ALL
Phase II multicentric study comparing VAD regimen with continuous infusion over 96 hours of doxorubicin, vincristine and dexamethasone to a 90 minutes infusion of equivalent doses of Dox li-PEG, bolus infusion of vincristine and…
- Trial name
- NCT00600977
- Testing
- Doxorubicine, Doxorubicine pegylated
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Innovative Leukemia Organisation
Non-small Cell Lung Carcinoma
Hypermetabolism in the Elderly Lung Cancer Patient
Aging and cancer are two conditions associated with extensive metabolic changes that can cause malnutrition. However, the clinical features and the underlying mechanisms leading to malnutrition are different in these two cases.
- Trial name
- HELP (NCT03141957)
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Paris 5 - Rene Descartes
Elderly Metastatic Colorectal Cancer Patients
First-line Combination of Capecitabine and Oxaliplatin Plus Bevacizumab in Elderly Patients With Metastatic Colorectal Cancer
Oxaliplatin-based doublets plus bevacizumab are standard first-line therapy options for patients (pts) with metastatic colorectal cancer (mCRC).
- Trial name
- COBRA (NCT03451370)
- Testing
- Capecitabine, Oxaliplatin, Bevacizumab
- Where
- Italy
- Volunteers
- 121 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Lung Cancer, Lung Carcinoma
Observational Study of the Efficacy and Safety of Anlotinib Combined With Penpulimab in Elderly Lung Cancer Patients
This prospective observational study will evaluate the efficacy and safety of anlotinib in combination with Penpulimab in elderly patients with lung cancer.
- Conditions
- Lung Cancer, Lung Carcinoma, Non Small Cell Lung Cancer, Non-small Cell Carcinoma
- Trial name
- AP (NCT05319886)
- Testing
- Anlotinib and Penpulimab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
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