Clinical trials: Electric Countershock
Atrium; Fibrillation, Atrium; Flutter
Refralon in Patients With Recurrence Paroxysmal and Persistent Forms of Atrial Fibrillation Who Underwent Catheter Ablation
It is planned to evaluate the efficacy and safety of the class III antiarrhythmic drug refralon as a drug for pharmacological cardioversion in patients with recurrent atrial fibrillation (AF) and atrial flutter (AFL) after…
- Trial name
- NCT05456204
- Testing
- Pharmacological cardioversion with Refralon
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Left Atrial Appendage Thrombi
Detection of Left Atrial Appendage (LAA) Thrombus: Comparison of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram
The purpose of this study is to compare Cardiac Magnetic Resonance (CMR) Imaging with transesophageal echocardiography (TEE) in detecting the presence of LAA thrombi in men and women with atrial fibrillation presenting for…
- Trial name
- NCT00797576
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gundersen Lutheran Medical Foundation
Heart Failure, Congestive
Resynchronization/Defibrillation for Ambulatory Heart Failure Trial
Congestive heart failure (CHF) is a common health problem that leads to frequent hospitalizations and an increased death rate. In spite of advances in drug therapy, it remains a significant public health problem.
- Trial name
- RAFT (NCT00251251)
- Testing
- Optimal Medical Therapy plus ICD, Optimal Medical Therapy plus CRT/ICD
- Where
- 33 sites in Australia, Belgium and 5 more
- Volunteers
- 1,798 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Sudden Cardiac Death
POWER (Pulse Width Optimized Waveform Evaluation Trial)
The objective of this study is to compare the ULV (Upper Limit of Vulnerability)/DFT (Defibrillation Threshold) efficacy between the 2.5, 3.5 and 4.5 ms membrane time constant based biphasic defibrillation waveforms.
- Trial name
- NCT00311181
- Testing
- Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation (AF)
Exercise-induced Cardioversion in Persistent Atrial Fibrillation
This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF…
- Trial name
- ExPAF (NCT07008066)
- Testing
- Bicycle ergometer excercise, Standard care with electrical cardioversion
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Paroxysmal Atrial Fibrillation
Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents
The main objective of this project is to study the efficacy and the mechanistic value of blocking both atrial specific and atria-preferential dynamics of ionic currents to terminate paroxysmal atrial fibrillation (AF).
- Trial name
- SELECTCARFAP (NCT03005366)
- Testing
- Vernakalant, Flecainide
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- David Filgueiras-Rama
Atrial Fibrillation
Study on OMT-28 in Maintenance of Sinus Rhythm in Patients With Persistent Atrial Fibrillation (AF)
This is a randomized, double-blind, dose-finding, placebo-controlled, parallel group, multicenter, phase II study to evaluate the efficacy, safety, and popPK of three different doses of OMT-28 given once daily versus placebo in…
- Trial name
- PROMISE-AF (NCT03906799)
- Testing
- OMT-28
- Where
- 25 sites in Bulgaria, Czechia and 2 more
- Volunteers
- 136 people
- Sponsor
- Omeicos Therapeutics GmbH
Atrial Fibrillation
Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study
The investigators will seek to determine the safety and efficacy of high-dose amiodarone (2000mg), given as a single uniform oral dose, for the treatment of acute atrial fibrillation in both a hospital inpatient and ambulatory…
- Trial name
- AAA (NCT04594746)
- Testing
- Amiodarone Hydrochloride
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Calgary
Atrial Fibrillation
COlchicine for the Prevention of Post Electrical Cardioversion Recurrence of AF
There is substantial evidence linking inflammation to the initiation and perpetuation of AF. Although the precise mechanism by which inflammation contributes to the development of AF remains unclear, it has been proposed that…
- Trial name
- COPPER-AF (NCT02582190)
- Testing
- Colchicine group
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Heart Failure, Congestive, Ventricular Fibrillation
Safety and Effectiveness of Cardiac Resynchronization Therapy With Defibrillation
The purpose of this study was to determine if cardiac resynchronization therapy when combined with defibrillation is safe and effective in the treatment of symptomatic heart failure.
- Conditions
- Heart Failure, Congestive, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- NCT00387803
- Testing
- Cardiac Resynchronization Therapy with Defibrillation
- Where
- United States
- Volunteers
- 581 people
- Sponsor
- Boston Scientific Corporation
Emergency Medical Services, Electric Countershock
A Feasibility Study for Elective Cardioversion of Atrial Fibrillation at Home
The goal of this pilot, non-controlled, non-randomised, single centre, prospective intervention feasibility study is to assess the feasibility of a home DC-ECV in the treatment of recurrent symptomatic AF performed by APP in 25…
- Trial name
- Electra-1 (NCT06322836)
- Testing
- Duble current electro cardioversion
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- RAV Brabant MWN
Tachycardia
China (CN)_Magnetic Resonance Imaging (MRI)_Implantable Cardiac Defibrillator (ICD) [CN_MRI_ICD]
This clinical study is to evaluate the safety and effectiveness of the Ellipse VR/DR implantable cardiac defibrillators (ICDs) and the Quadra Assura MP cardiac resynchronization therapy defibrillators (CRT-Ds), with Durata or…
- Trial name
- CN_MRI_ICD (NCT03828357)
- Testing
- Study MRI scan
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Heart Failure
The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure
The purpose of this study is to evaluate the efficacy of ranolazine in the prevention of recurrent atrial fibrillation in post-cardioversion patients with heart failure and preserved ejection fraction.
- Trial name
- RAD HF (NCT01887353)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Intermountain Health Care, Inc.
Sudden Cardiac Arrest
Research on Attitudes, Confidence, and Practical Skills in Performing Cardiopulmonary Resuscitation and Automated External Defibrillation After Completing a Course Based on the European Resuscitation Council Model
Research on attitudes, confidence, and practical skills in performing cardiopulmonary resuscitation and automated external defibrillation after completing a course based on the European Resuscitation Council model
- Trial name
- RACE-CPR (NCT07331831)
- Where
- Bulgaria
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- First Three Minutes Foundation
Atrial Fibrillation
QT Variability Pre and Post Cardioversion
The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.
- Trial name
- DCCV (NCT00885391)
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Vanderbilt University
Persistent Atrial Fibrillation
Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure
This study aims at assessing whether electric cardioversion can act as a discriminant factor between patients requiring Pulmonary Vein Isolation (PVI) procedure alone or PVI procedure combined with substrate modulation.
- Trial name
- PACIFIC (NCT05264831)
- Testing
- Pulmonary Vein Isolation (PVI) alone, PVI procedure associated with substrate modulation
- Where
- 13 sites in France
- Volunteers
- 450 people
- Sponsor
- Elsan
Death, Sudden, Cardiac, Ventricular Fibrillation
Automatic External Defibrillation Monitoring in Cardiac Arrest
We propose to randomize automatic external cardioverter/defibrillators (AECD) in patients who are at high risk for life-threatening abnormal heart rhythms (arrhythmias) and are admitted to the telemetry ward, all other treatments…
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- NCT00382928
- Testing
- Defibrillation of pulseless VT/VF by AECD
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
Monomorphic Ventricular Tachycardia
Evaluation of Inducible Monomorphic Ventricular Tachycardia (MMVT) in Patients With St. Jude Medical (SJM) Implantable Cardioverter Defibrillator (ICD) Systems or Cardiac Resynchronization Therapy Defibrillation (CRT-D) Systems.
The intent of this observational study is to understand the role of non-invasive programmed stimulation (NIPS) to induce substrate based MMVT (Monomorphic Ventricular Tachycardia) in patients receiving new St.
- Trial name
- EPIC (NCT02584595)
- Testing
- ICD/CRT-D with NIPS or EP Study
- Sponsor
- Abbott Medical Devices
Persistent Atrial Fibrillation
Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion
Dose-ranging Phase II study testing the efficacy and safety of 3 doses of Ranolazine (low, intermediate and high, given BID) versus placebo in maintaining sinus rhythm after successful electrical cardioversion in patients with…
- Trial name
- RAFFAELLO (NCT01534962)
- Testing
- Ranolazine
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 241 people
- Sponsor
- Menarini Group
Atrial Fibrillation (AF)
Cardiac Stunning After Electrical Cardioversion
The goal of this observational study is to evaluate cardiac stunning and electrocardiographic parameters through transthoracic echocardiography and 24 hours ECG conducted immediately following electrical cardioversion.
- Trial name
- AMPEA (NCT06752733)
- Testing
- electrical cardioversion
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Korea University Guro Hospital