Clinical trials: Electrical Remodeling
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: Interaction Between HyperCoagulability, Electrical Remodeling, and Vascular Destabilisation in the Progression of Atrial Fibrillation
The purpose of this study is to study clinical factors and (blood) biomarkers related to progression of Atrial Fibrillation (AF) in patients diagnosed with self-terminating AF with special reference to hypercoagulability.
- Trial name
- RACE V (NCT02726698)
- Where
- 9 sites in Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Atrial Fibrillation (AF)
Epicardial Adipose Tissue-Targeted DApagliflozin for Reducing Electrical Remodeling in Atrial Fibrillation
Persistent atrial fibrillation (PeAF) is associated with a high risk of recurrence following catheter ablation despite advances in ablation technology and strategies.
- Trial name
- EAT-DARE-AF (NCT07331727)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF), Arrhythmia
Computed Tomography of Pulse-Field Ablation
Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) reduces left atrial (LA) volume post-ablation, a phenomenon termed reverse atrial remodeling, indicative of successful reversal of atrial cardiomyopathy…
- Trial name
- CT-PFA (NCT07395089)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence
Ezetimibe for Arrhythmia Recurrence After AF Ablation
This single-center, prospective, single-blind randomized controlled pilot trial aims to explore whether oral ezetimibe can reduce the 6-month recurrence rate of atrial tachyarrhythmia after catheter ablation in patients with…
- Trial name
- EAFA (NCT07752758)
- Testing
- Ezetimibe, Standardized post-ablation clinical management
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
SGLT 2 Inhibitors
Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling in Diabetic Patients
To evaluate and follow-up left atrial volume, diastolic function by 2D echocardiography and left atrial strain parameters using speckle-tracking echocardiography in patients with type 2 diabetes mellitus (T2DM) before and after…
- Trial name
- NCT07186153
- Testing
- Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
- Volunteers
- 100 people
- Sponsor
- Assiut University
Atrial Fibrillation, Atrial Flutter
Impact of Catheter Ablation on ABC Risk Scores
The aim of this prospective, monocentric, non-randomized trial is to investigate the impact of catheter ablation of atrial tachyarrhythmias on the ABC-stroke and ABC-bleeding risk scores.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Stroke, Bleeding
- Trial name
- CathonABC (NCT05635864)
- Testing
- Catheter ablation
- Where
- Germany
- Volunteers
- 167 people
- Sponsor
- Hannover Medical School
Acute Myocardial Infarction
Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction
This purpose of this study is to examine the relationship between HMGB-1 and postinfarction predictors of outcome such as cardiopulmonary and echocardiographic parameters before and after a 6-month exercise-based cardiac…
- Trial name
- NCT00755131
- Testing
- Exercise-based Cardiac Rehabilitation program
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Federico II University
Atrial Remodeling
Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias
The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the…
- Trial name
- CLASS-VA (NCT06425822)
- Testing
- Left atrial electroanatomical mapping
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cardiovascular-Kidney-Metabolic Syndrome, Atrial Cardiomyopathy
Atrial Cardiomyopathy in Patients With Cardiovascular-Kidney-Metabolic Syndrome: Non-invasive Characterization
Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors, chronic kidney disease, and the cardiovascular system, leading to multiorgan…
- Conditions
- Cardiovascular-Kidney-Metabolic Syndrome, Atrial Cardiomyopathy, Atrial Fibrillation, Chronic Kidney Disease
- Trial name
- ATRIO-CKM (NCT07697469)
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Heart Failure, Patients Undergoing CRT-D Device Implantation
Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS.
- Trial name
- RER-CRT (NCT01924221)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation
Stepwise Strategy for Treatment of Atrialfibrillation Substrate Study
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesized that radiofrequency ablation surgery for atrial fibrillation has a higher success rate and a lower recurrence rate of atrial…
- Trial name
- SAFE (NCT07129564)
- Testing
- treatment react
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yuehui Yin
Atrial Fibrillation
Flecainide-Short Long Study (Flec-SL)
A randomized trial to test the hypothesis that short-term pharmacological reversal of electrical remodeling after cardioversion is equally efficient to prevent recurrent atrial fibrillation as standard long-term antiarrhythmic…
- Trial name
- NCT00215774
- Testing
- Flecainide
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- Atrial Fibrillation Network
Atrial Fibrillation, Atrial Remodeling
High-density Mapping-guided bOx Isolation and subsTrate Ablation
This study evaluates the efficacy of high-density mapping guided atrial substrate ablation for persistent atrial fibrillation. 1/5 of the patients with persistent atrial fibrillation undergo pulmonary veins isolation, 2/5 of them…
- Trial name
- HOT (NCT03998956)
- Testing
- CPVI, CPVI+BOX, CPVI+BOX+SUB
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: RACE-V - Work Package 5
In the proposed study the investigators aim to clarify the relative contribution of these different mechanisms to the progression of atrial fibrillation (AF).
- Trial name
- RACE V- WP 5 (NCT03124576)
- Testing
- Implantable loop recorder
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Leg Ulcer, Electrical Remodeling
Electrostimulation System WoundEL for Leg Ulcers Healing (
Several studies have suggested that the endogenous electric field and its polarity stimulate the proliferation and migration of epithelial cells and therefore promote wound healing.
- Trial name
- ELEXICA (NCT04980898)
- Testing
- WoundEL medical device, Standard cares
- Where
- France
- Volunteers
- 22 people
- Sponsor
- CEN Biotech
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Atrial Fibrillation, Atrial Flutter
Use of Fish Oils to Prevent Atrial Mechanical Stunning and Atrial Remodeling Due to Atrial Arrhythmia
The purpose of this study is to investigate whether fish oils may be of benefit to patients with certain heart rhythm disturbances called atrial fibrillation and atrial flutter.
- Trial name
- NCT00232232
- Testing
- Fish oil
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Melbourne Health
Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular End Diastolic Pressure (LVEDP)
Evaluation of Left Ventricular Filling Pressures During Exercise
Heart failure with preserved ejection fraction (HFPEF) is common and is a real public health issue. Diagnosis, especially when there are no congestive signs, is difficult.
- Trial name
- PREFFORT (NCT01714752)
- Testing
- measure of left ventricular and diastolic pressure at exercise
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Cardiology Society
Atrial Fibrillation (AF), Obesity (Disorder)
Improving Outcomes After AF Ablation in Obese Patients
Improving Outcomes After AF Ablation in Obese Patients
- Trial name
- OBESE-AF (NCT07618741)
- Testing
- Cardiac Rehabilitation and Lifestyle Modification, Usual Care
- Where
- Taiwan
- Volunteers
- 520 people
- Sponsor
- National Taiwan University Hospital