Clinical trials: Electrical Remodeling
Atrial Fibrillation, Cardiac Remodeling, Atrial
Effect of ARNI in Patients With Persistent AF and Enlarged Left Atrium After Catheter Ablation
The purpose of this clinical randomized trial is to evaluate the efficacy and safety of Sacubitril/Valsartan compared with ARB in improving cardiac remodeling in patients With Enlarged Left Atrium Diameter and Persistent AF.
- Conditions
- Atrial Fibrillation, Cardiac Remodeling, Atrial, Sacubitril/Valsartan
- Trial name
- APART-AF (NCT03791723)
- Testing
- Sacubitril-Valsartan, Valsartan
- Volunteers
- 90 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Atrial Fibrillation
Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling
Investigators are going to assess direct effect of SGLT2 inhibitors on left atrial remodeling in participants with nonvalvular paroxysmal atrial fibrillation regardless of diabetes status.
- Trial name
- NCT05993897
- Testing
- Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor, Rhythm control and anticoagulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Aswan University
Cardiac Pacing, Artificial, Tricuspid Valve Regurgitation, Non-rheumatic
Cardiac Implantable Electronic Device- Induced Remodelling of Tricuspid Valve and Right Chambers
This single-center longitudinal study aims to evaluate the occurrence and clinical impact of tricuspid regurgitation (TR) after cardiac-implanted-electronic-device (CIED) implantation by comprehensive echocardiographic…
- Trial name
- CIED-REMTRIC (NCT06914570)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Istituto Auxologico Italiano
Electrical Remodeling, Rheumatic Diseases
Peripherical Neuromuscular Electrical Stimulation in Systemic Autoimmune Myopathies
Systemic autoimmune myopathies are a heterogeneous group of rheumatic diseases with progressive skeletal muscle weakness. The relevance of the peripherical neuromuscular electrical stimulation has never applied in the patients…
- Conditions
- Electrical Remodeling, Rheumatic Diseases, Myopathy
- Trial name
- NCT03751644
- Testing
- Electrical stimulation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- University of Sao Paulo
Atrial Remodeling, Myocardial Dysfunction
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
Sacubitril-valsartan, an Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI), currently marketed for the management of heart failure, has been shown to reduce cardiovascular morbidity and mortality in stage C heart failure…
- Conditions
- Atrial Remodeling, Myocardial Dysfunction, Left Ventricular Remodeling, Left Ventricular Diastolic Dysfunction
- Trial name
- PARABLE (NCT04687111)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Mark Ledwidge
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Atrial Fibrillation
GISSI-AF - Use of Valsartan an Angiotensin II AT1-Receptor Blocker in the Prevention of Atrial Fibrillation Recurrence
Study purpose The purpose of the study is to show that the addition of valsartan on top of established therapies can reduce the recurrence of atrial fibrillation in patients with a history of recent atrial fibrillation associated…
- Trial name
- NCT00376272
- Testing
- Valsartan
- Where
- 114 sites in Italy, Switzerland
- Volunteers
- 1,442 people
- Sponsor
- Gruppo di Ricerca GISSI
Stroke, Acute Cerebrovascular Accident
Radiofrequency and Cryoablation of the Posterior Wall of the Left Atrium
Atrial fibrillation (AF) is the cause of 20% of strokes, and the risk of stroke in a person suffering from this arrhythmia increases by 5 times.
- Conditions
- Stroke, Acute Cerebrovascular Accident, Transient Ischemic Attack, Death
- Trial name
- NCT06253000
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Russia
- Volunteers
- 158 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Atrial Fibrillation (AF)
Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure.
- Trial name
- UNIQS-AF (NCT07630857)
- Testing
- Unipolar QS-Potential Guided Catheter Ablation, Conventional Pulmonary Vein Isolation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation
Early Versus Late DC-cardioversion of Persistent Atrial Fibrillation. Effect on Atrial Remodeling,Inflammatory and Neurohumoral Markers and Recurrence of Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia present in 1% of population under 60 years of age and reaching up to 15% at 80 years.
- Trial name
- NCT01593150
- Testing
- Pradaxa, TEE, Compare TEE guided cardioversion to Dabigatran + DC cardioversion
- Where
- Denmark
- Volunteers
- 141 people
- Sponsor
- Odense University Hospital
Heart Failure
Impact on Atrial Remodeling of Dapaglifozin in Patients With Heart Failure .
Dapagliflozin reduces the risk of de novo heart failure (HF) in diabetics and, recently, it has shown to improve the prognosis of patients with HF and reduced left ventricular ejection fraction (HFrEF), by preventing HF…
- Trial name
- MODA (NCT04707352)
- Testing
- Dapagliflozin
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Persistent Atrial Fibrillation
Effect of Catheter Ablation on Left Atrial Function in Persistent Atrial Fibrillation
A total of 106 patients with drug-refractory persistent atrial fibrillation, who are planned to undergo circumferential pulmonary vein isolation (CPVI), will be randomly allocated into two groups.
- Trial name
- NCT03443232
- Testing
- Cryoballoon ablation, Radiofrequency ablation
- Where
- China
- Volunteers
- 106 people
- Sponsor
- The Second Hospital of Hebei Medical University
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Tricuspid Regurgitation, Right Heart Failure
Pforzheim Tricuspid Valve Registry - Outcomes of Percutaneous Tricuspid Valve Repair
The Pforzheim Tricuspid Valve Registry study is designed to confirm the safety and performance of the TriClip™ device in a contemporary real-world setting in critically ill patients.
- Conditions
- Tricuspid Regurgitation, Right Heart Failure, Cardiac Remodeling, Ventricular, Cardiac Remodeling, Atrial
- Trial name
- NCT05179616
- Testing
- Transcatheter edge-to-edge tricuspid valve repair
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Helios Klinikum Pforzheim
Sick Sinus Syndrome
Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)
A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead.
- Trial name
- NCT00785564
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation
The Influence of Catheter Ablation for Atrial Fibrillation on Atrial Electrical
This study explored the influence of radiofrequency catheter ablation and cryoballoon ablation on atrial electrical remodeling in patients with atrial fibrillation,the relationship between atrial electrical remodeling and…
- Trial name
- NCT03322085
- Testing
- radiofrequency ablation or cryoballoon
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation, Electrocardiography
CArdioversion of Short Duration Atrial Fibrillation
The study is aimed at testing the hypothesis whether atrial fibrillary rate (AFR), as a measure of atrial electrical remodeling assessed from surface ECG, is predictive of sinus rhythm maintenance after electrical cardioversion.
- Conditions
- Atrial Fibrillation, Electrocardiography, Electrical Remodeling
- Trial name
- CASAF (NCT02112318)
- Where
- 3 sites in Canada, Sweden
- Volunteers
- 32 people
- Sponsor
- Region Skane
Persistent Atrial Fibrillation, Atrial Fibrillation (AF)
Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)
Atrial fibrillation (AF) is associated with both electrical and structural remodeling of the left atrium. While successful catheter ablation has been shown to reverse some aspects of atrial remodeling, the impact of pulsed-field…
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation (AF), Atrial Remodeling, Pulsed Field Ablation
- Trial name
- NCT07675395
- Testing
- Pulsed-Field Ablation with FARAWAVE Catheter System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Atrial Fibrillation, Hypertension
Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers
The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent…
- Trial name
- NCT00225667
- Testing
- Irbesartan
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Connolly, Stuart, M.D.