Clinical trials: Electrical Stimulation of the Brain
Reward-guided Behaviour
Oscillations in Reward-guided Behavior
While people are reading, talking or playing computer games, their brain cells elicit electrical signals so they could perform these actions.
- Trial name
- NCT04761471
- Testing
- TI transcranial electrical stimulation
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Transcranial Electrical Stimulation, Temporal Lobe Epilepsy
Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe Epilepsy
Study the therapeutic effect and potential neural mechanisms of transcranial electrical stimulation targeting the cerebellum for the treatment of refractory temporal lobe epilepsy through MRI and EEG.
- Conditions
- Transcranial Electrical Stimulation, Temporal Lobe Epilepsy, Magnetic Resonance Imaging, Electroencephalogram
- Trial name
- NCT06558890
- Testing
- Transcranial Alternating Current Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Disorder of Consciousness
Alpha tACS for Disorders of Consciousness : a Single Case Experimental Design
BRIEF SUMMARY * (Include a statement of the study hypothesis) Avoid all personal pronouns (Limit: 5000 characters) Disorders of consciousness (DoC) following a severe traumatic brain injury represent a major medical challenge…
- Trial name
- SPARC (NCT07213869)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
Safety and Efficacy of Motor Cortex Stimulation in the Treatment of Advanced Parkinson Disease
The purpose of this study is to determine whether motor cortex stimulation, a mildly invasive surgical procedure, is safe and effective in advanced stage Parkinsonian patients who display side effects with dopaminergic treatment.
- Trial name
- NCT00159172
- Testing
- Motor cortex stimulation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain
Home-based Transcranial Stimulation in the Treatment of Patients With Refractory Chronic Pain
Refractory chronic pain represents a serious and limiting health condition which does not respond to standard pharmacological therapy.
- Trial name
- NCT05099406
- Testing
- Transcranial electrical stimulation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Santiago de Compostela
Drug-Resistant Focal Epilepsy
Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring
This study evaluates whether a non-invasive brain stimulation technique called Temporal Interference (TI) can reduce epilepsy-related abnormal brain activity and influence sleep-related brain rhythms in adults with focal…
- Trial name
- NCT07764718
- Testing
- Temporal Interference Stimulation, Direct Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Migraine
The Evaluation of the Transcutaneous Electrical Stimulation Medical Device's Safety and Effectiveness in Treating the Patients With Migraine
The purpose of this study is to investigate the safety and effectiveness of trigeminal nerve electrical stimulator on reducing the frequency of migraine onset.
- Trial name
- NCT05301920
- Testing
- Elexir (trigeminal nerve electrical stimulator)
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Nu Eyne Co., Ltd.
Stroke
Non-invasive Neuromodulation NESA Application in the Rehabilitation of Stroke Sequelae
To evaluate whether NESA microcurrents can be used as an effective treatment for various sequelae present in stroke patients, specifically in the treatment of spasticity, balance, pain; and whether it affects quality of life…
- Trial name
- NCT05853952
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Las Palmas de Gran Canaria
Stroke, Dysphagia
Pharyngeal Electrical Stimulation for the Treatment of Post-extubation Dysphagia in Acute Stroke
The purpose of this study is to evaluate whether pharyngeal electrical stimulation in addition to standard care can enhance swallowing recovery in severely dysphagic stroke patients post extubation compared to sham treatment plus…
- Trial name
- NCT02470078
- Testing
- Phagenyx-Catheter, Phagenesis Limited, UK.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Muenster
Stroke
The Therapeutic Effects of Peroneal Nerve Functional Electrical Stimulation for Lower Extremity in Patients With Sub-acute Post-stroke Hemiplegia
Among the sequelae of stroke, gait disorder is directly linked to the degree of autonomy in the daily life of patients. It is considered significant effects on their Quality of Life(QOL).
- Trial name
- RALLY (NCT02898168)
- Testing
- WA group, Control
- Where
- 31 sites in Japan
- Volunteers
- 202 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Multiple Sclerosis
Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited.
- Trial name
- NCT06401928
- Testing
- transcranial direct current stimulation, transcranial direct current stimulation combined with cognitive training
- Where
- Iran
- Volunteers
- 53 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Lennox Gastaut Syndrome
Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut Syndrome
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of pallidothalamic tracts as adjunctive therapy for alleviating symptoms in Lennox-Gastaut Syndrome.
- Trial name
- PESL (NCT06464653)
- Testing
- Forel's Field H-DBS ON
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Liankun_Ren
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Stroke
Electrical Stimulation After Botulinum Toxin Injections to the Upper Extremity
The purpose of this study is to investigate the effectiveness of using electrical stimulation to improve upper extremity function in stroke survivors who receive botulinum toxin injections for spasticity.
- Trial name
- NCT04217187
- Testing
- Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Texas Woman's University
Tumor, Brain
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation
Elucidating the structure-function relationship of the brain is one of the main open questions in neuroscience. The capabilities of diffusion MRI-based (dMRI) techniques to quantify the connectivity strength between brain areas…
- Trial name
- NCT03503110
- Testing
- electrocorticography with electrostimulation, dRMI
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Stroke, Healthy Health Care Professionals
Usability and Acceptability Study of a Functional Electro-stimulator Controlled by Electromyographic Signal (FitFES)
Functional recovery of the upper limb after a cerebral stroke is one of the major critical issues in rehabilitation. The advent of innovative technologies can be helpful to rehabilitators and intervene where there is no other…
- Trial name
- NCT06763874
- Testing
- EMG-based FES device
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Efficacy of the WalkAide and AFOs for CVA
To assess the effectiveness of a new stimulator (WalkAide) for the treatment of foot drop. The comparison will involve physical measurements (e.g.
- Trial name
- NCT00216320
- Testing
- WalkAide, AFO
- Where
- 5 sites in United States
- Volunteers
- 121 people
- Sponsor
- Innovative Neurotronics
Traumatic Brain Injury
Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury
Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients.
- Trial name
- NCT04239274
- Testing
- transcranial direct current stimulation, transcranial pulsed current stimulation
- Sponsor
- Medical University of South Carolina
Alzheimer Disease
Novel Personalized Non Invasive Combined Magnetic and Electrical Stimulation of the DMN in Mild AD Patients
Alzheimer's disease (AD) is increasingly recognized as a disorder marked by early synaptic dysfunction and disrupted brain network connectivity, beyond the traditional focus on amyloid pathology.
- Trial name
- CMES_AD (NCT07075770)
- Testing
- Combined iTBS-tACS
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Traumatic Brain Injury
Feasibility of the Radio-Frequency Microstimulator System to Improve Arm Function Following Traumatic Brain Injury
This study will evaluate the feasibility of using fully implanted microstimulators to rehabilitate arm function in patients who have suffered a traumatic brain injury.
- Trial name
- NCT01488981
- Testing
- Upper Extremity Therapy without stimulation, Upper Extremity Therapy with stimulation from the Radiofrequency Microstimulator (RFM) System (Alfred Mann Foundation, Santa Clarita, CA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The Alfred E. Mann Foundation for Scientific Research