Clinical trials: Electrical Stimulation of the Brain
Obsessive-Compulsive Disorder
Comparison of DBS Targets in Obsessive-compulsive Disorder
Deep brain stimulation (DBS) has been proposed for severe and resistant obsessive-compulsive disorder. This electrical stimulation has been tested on, and shown to be effective at, different targets (subthalamic nucleus, caudate…
- Trial name
- PRESTOC2 (NCT01807403)
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy, Spastic
Functional Electrical Stimulation During Walking in Cerebral Palsy
Children with spastic cerebral palsy (CP) often walk with insufficient ankle dorsiflexion in the swing phase. A pathological gait, known as drop-foot gait, can be the result and this has 2 major complications: foot-slap during…
- Conditions
- Cerebral Palsy, Spastic, Foot Drop
- Trial name
- NCT03440632
- Testing
- FES
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Healthy
Effect of Electrical Stimulation (DC Polarization) to the Brain on Memory
This study will test the effect of direct current (DC) brain polarization (the application of a very weak electrical current to the brain) on learning and memory.
- Trial name
- NCT00471107
- Testing
- DC brain polarization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Major Depressive Disorder, Unipolar Depression
Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study
First-line treatments for major depressive disorder (MDD), antidepressants and psychotherapy, are associated with refractoriness and discontinuation due to side effects, and logistical burdens, respectively.
- Trial name
- PSYLECT (NCT04889976)
- Testing
- Double Active: Active portable transcranial stimulation (ptES) and active internet-based behavioral therapy (iBT)
- Where
- 2 sites in Brazil
- Volunteers
- 210 people
- Sponsor
- University of Sao Paulo
Obsessive-compulsive Disorder (OCD)
Deep Electrical Neuromodulation in Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disease characterised by intrusive, recurrent and persistent thoughts, urges or images (obsessions) and the resulting excessive repetitive behaviours or mental acts…
- Trial name
- NEP-TOC (NCT03605316)
- Testing
- Deep brain stimulation (DBS)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Montpellier
Stroke, Hemiparesis
Safety and Effectiveness of Cortical Stimulation in the Treatment of Stroke Patients With Upper Extremity Hemiparesis
The purpose of this study is to assess the safety and effectiveness of cortical stimulation delivered concurrent with rehabilitation activities to enhance motor recovery in patients suffering from hemiparesis affecting the upper…
- Trial name
- EVEREST (NCT00170716)
- Testing
- Cortical Stimulation and rehabilitation, Rehabilitation
- Where
- 21 sites in United States
- Volunteers
- 174 people
- Sponsor
- Northstar Neuroscience
Epilepsy, Drug Resistant
Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Subiculum as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with…
- Trial name
- NCT06436547
- Testing
- Subiculum-DBS ON
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute
Electrical Stimulation of the Paretic Upper Limb in the Early Stroke Phase
This study evaluates the effect of electrical somatosensory stimulation (ESS) on the restoration of upper limb functioning in acute stroke patients.
- Trial name
- NCT02250365
- Testing
- Continuous, suprasensory ESS, Intermittent, suprasensory ESS
- Where
- 3 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- University of Copenhagen
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Dysphagia
Neuromuscular Electroestimulation and Respiratory Muscle Training in Subacute Stroke
This study, part of a larger research project (The Retornus Study), is aimed to evaluate new strategies to optimize rehabilitation outcomes in dysphagic stroke patients.
- Trial name
- NCT02473432
- Testing
- RMT + usual care, NMES, Usual care
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Parc de Salut Mar
Fibromyalgia
The Clinical Effect of Low-Intensity Electromagnetic Field Neurostimulation in Fibromyalgia Syndrome Patients
The purpose of this study is to determine whether persons treated with a low-intensity, noninvasive form of cortical electrical stimulation experience a reduction in symptoms of fibromyalgia different than persons receiving a…
- Trial name
- NCT01180244
- Testing
- Noninvasive cortical electrical stimulation
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- McLaren Regional Medical Center
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Cognitive Function Abnormal, Atrial Fibrillation (AF)
Low-frequency Electrical Stimulation for Cognitive Enhancement in Atrial Fibrillation
Cognitive function in patients with atrial fibrillation (AF) is often impaired due to the complex influence of various factors (cerebral hypoperfusion, neurodegeneration, microemboli, hypertension, chronic inflammation).
- Trial name
- LESCAF (NCT07063381)
- Testing
- tVNS
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Cerebral Palsy
The Effects of Electrical Stimulation Gait Training on Walking and Posture for Children With Cerebral Palsy
This proposal is designed to achieve the following specific aims and will test the associated hypotheses: AIM 1: To compare walking ability, standing posture, gait initiation and functional standing and stepping of twenty…
- Trial name
- NCT00292786
- Testing
- Walking Practice with Functional Electrical Stimulation, Walking Practice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
TBI (Traumatic Brain Injury)
Asia Coma Electrical Stimulation (the ACES Trial)
This study is a prospective multicenter randomized controlled trial from Asian countries to compare the effect and safety of right median nerve stimulation versus traditional treatment for comatose patients at the early stage…
- Trial name
- ACES (NCT02645578)
- Testing
- Right median nerve stimulation
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Parkinson Disease, Movement Disorders
Deep Brain Stimulation to Treat Symptoms of Parkinson's Disease
The purpose of this study is to evaluate the safety and efficacy of bilateral stimulation of the subthalamic nucleus (STN) of the brain when using the ANS Totally Implantable Deep Brain Stimulation System as an adjunctive…
- Trial name
- NCT00552474
- Testing
- Libra Deep Brain Stimulation System
- Where
- 15 sites in United States
- Volunteers
- 136 people
- Sponsor
- Abbott Medical Devices
Metaplasticity
Improving Hand Movement Training Through Electrical Stimulation of the Brain
This study will determine if applying electrical stimulation of the brain can influence training to perform finger movements. The study may provide information that can be used to design rehabilitation therapies for people who…
- Trial name
- NCT00331318
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Acute Effects of Wearable Electrical Stimulation in Stroke
The goal of this clinical trial is to learn if the EXOPULSE Mollii Suit Wearable Electrical Stimulation works to reduce spasticity and improve functional capacity in individuals with stroke.
- Trial name
- NCT07459361
- Testing
- EXOPULSE Mollii Suit
- Volunteers
- 26 people
- Sponsor
- Hacettepe University
Cerebral Palsy
Efficacy of New Protocols in the Treatment of Upper Limb Dysfunctions in Patients With Cerebral Palsy
Immediate and maintaining Efficacy of new protocols in the treatment of upper limb dysfunctions in patients with cerebral palsy.
- Trial name
- NCT03048851
- Testing
- Low dosage SES group, High dosage SES group, VRCIT group
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chang Gung Memorial Hospital