Clinical trials: Electrolyte Disturbance in Gastrointestinal Diseases
Liver Disease, Hyponatremia
Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function
A study to compare a 48-hour continuous infusion of conivaptan in subjects with mild and moderate liver impairment versus subjects with normal liver function
- Trial name
- NCT00851227
- Testing
- conivaptan hydrochloride
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cumberland Pharmaceuticals
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Liver Cirrhosis, Hyponatremia
Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
This is a phase IV, open-label, prospective cohort study for 7 days.The recommended starting dose of tolvaptan is 15 mg daily orally.
- Trial name
- OASIS (NCT01850940)
- Testing
- Tolvaptan, conventional thearpy
- Where
- 19 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Friendship Hospital
Gastroenteritis, Rota Virus Gastroenteritis
Admission Pattern Among Children With Gastro-intestinal Infections Before and During the Covid-19 Pandemic
During the Covid-19 pandemic, admission patterns for infections other than Covid-19 have changed dramatically among children worldwide.
- Conditions
- Gastroenteritis, Rota Virus Gastroenteritis, Dehydration in Children, Infectious Disease
- Trial name
- NCT06211621
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Region Zealand
Gastroenteritis, Dehydration
Study Investigating the Use of Intravenous Fluids With Dextrose for Dehydrated Children
Infants and young children often become infected with gastroenteritis leading to vomiting and diarrhea. This can lead to dehydration, one of the most common complaints in the Pediatric Emergency Department.
- Trial name
- NCT01343758
- Testing
- 5% dextrose in normal saline
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona
Hyponatremia, SIADH
Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia
Hyponatremia is the most common electrolyte derangement occurring in hospitalized patients. It is usually classified as hypovolemic, euvolemic or hypervolemic.
- Conditions
- Hyponatremia, SIADH, Liver Failure, Kidney Failure
- Trial name
- EMPOWER (NCT04447911)
- Testing
- Empagliflozin 25 MG
- Where
- 6 sites in Germany, Netherlands and 1 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Basel, Switzerland
Ileostomy - Stoma, Colorectal Surgery
Readmission and Dehydration Prevention in Patients With Elective Ileostomy
The goal of this prospective observational study is to evaluate the adherence to DRIP score calculation and the application rate of each proposed item to prevent dehydration and readmission in patients undergoing ileostomy…
- Conditions
- Ileostomy - Stoma, Colorectal Surgery, Dehydration
- Trial name
- PREDESTO (NCT06824623)
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Multidisciplinary Italian Study group for STOmas (MISSTO)
Nutritional Deficiency, Ileostomy; Functional Disturbance
Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Clinical trial, active comparator, cross over, randomised. In total, 12 adults with an ileostomy will be randomised to a sequential 4 weeks intervention with different qualities and sources of protein wish 2-week washout periods.
- Conditions
- Nutritional Deficiency, Ileostomy; Functional Disturbance, Short Bowel Syndrome, Absorption; Disorder, Protein
- Trial name
- ABSOLYT (NCT04141826)
- Testing
- Hydrolysed whey, Intact whey, Caseinate
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Hvas
Dehydration, Gastroenteritis
Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in Pakistan
The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children…
- Conditions
- Dehydration, Gastroenteritis, Vomiting, Diarrhea
- Trial name
- OWEP (NCT01870635)
- Testing
- Ondansetron
- Where
- 2 sites in Pakistan
- Volunteers
- 625 people
- Sponsor
- Dr. Stephen Freedman
Colorectal Cancer
C-Reactive Protein and Sodium in Predicting Anastomotic Leakage
Anastomotic leakage is serious morbidity that can develop in patients operated on for colorectal cancer and can reach potentially life-threatening dimensions.
- Trial name
- NCT04717648
- Testing
- Biochemical test
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tepecik Training and Research Hospital
Ileostomy - Stoma, Intestinal Failure
Optimised Osmolality in Oral Supplements Optimised Osmolality in Oral Supplements
Quasi-randomized, crossover intervention study, testing osmolality in oral drinks and effect on 6-hours ileostomy output in adult patients with an ileostomy
- Trial name
- Goldilocks (NCT07231666)
- Testing
- water, semi skimmed milk or powerade, juice
- Where
- 2 sites in Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Dehydration
IV Glucose for Dehydration Treatment
To determine whether the addition of dextrose to IV fluids in the treatment of gastroenteritis leads to a decrease in serum ketones.
- Trial name
- NCT01285713
- Testing
- 5% Dextrose (D5) in Normal Saline (NS), Normal Saline (NS)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hypercalcemia, Familial Primary Hyperparathyroidism
Cinacalcet to Treat Familial Primary Hyperparathyroidism
This study will evaluate the benefits and side effects of a new medication called Cinacalcet for treating patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 (MEN1) or type 2A (MEN2A).
- Trial name
- NCT00325104
- Testing
- Parathyroid hormone testing, Serum calcium testing
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Swallowing Disorder, Oropharyngeal Dysphagia
Effectiveness of an Optimal-Massive Intervention in Older Patients With Dysphagia
The aim of this study is to evaluate the efficacy of an optimal-massive intervention (OMI) based on increasing shear viscosity of fluids, nutritional support with oral nutritional supplements (ONS) and triple adaptation of food…
- Conditions
- Swallowing Disorder, Oropharyngeal Dysphagia, Respiratory Infection, Malnutrition
- Trial name
- OMI (NCT04581486)
- Testing
- Optimal-Massive Intervention, Control (standard clinical practice)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital de Mataró
Cirrhosis, Hepatic Encephalopathy
Effect of Tolvaptan on Cognitive Function in Cirrhosis
Hypothesis: Tolvaptan will improve cognitive function, brain edema and health-related quality of life in cirrhotic patients with hyponatremia
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Hyponatremia
- Trial name
- NCT01556646
- Testing
- Tolvaptan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Dehydration, Gastroenteritis
Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan
The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children…
- Conditions
- Dehydration, Gastroenteritis, Vomiting, Diarrhea
- Trial name
- OSEP (NCT01870648)
- Testing
- Ondansetron
- Where
- 2 sites in Pakistan
- Volunteers
- 918 people
- Sponsor
- Dr. Stephen Freedman
Dehydration, Gastroenteritis
Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
Dehydration due to vomiting is a common complication of acute gastroenteritis in children. Persistent vomiting following rehydration is a problem in outpatient management using oral rehydration therapy.
- Trial name
- NCT00691275
- Testing
- Ondansetron, Saline
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Gastroenteritis, Dehydration
Rotavirus Burden and Genotypes in a Sentinel Hospital Surveillance System in Lebanon
This study aims to determine the contribution of rotavirus infection as a cause of gastroenteritis requiring hospitalization in children younger than 5 years of age.
- Trial name
- NCT01321216
- Where
- 4 sites in Lebanon
- Volunteers
- 1,555 people
- Sponsor
- American University of Beirut Medical Center
Breast Cancer, Hypercalcemia of Malignancy
Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium
The purpose of this study is to determine the potential of denosumab to treat Hypercalcemia of Malignancy in patients with elevated serum calcium who do not respond to recent treatment with intravenous bisphosphonates by lowering…
- Conditions
- Breast Cancer, Hypercalcemia of Malignancy, Colon Cancer, Endocrine Cancer
- Trial name
- NCT00896454
- Testing
- denosumab
- Where
- 24 sites in United States, Canada and 3 more
- Volunteers
- 33 people
- Sponsor
- Amgen