Clinical trials: Electrolyte Disturbance in Gastrointestinal Diseases
Gastroenteritis, Dehydration
Study Investigating the Use of Intravenous Fluids With Dextrose for Dehydrated Children
Infants and young children often become infected with gastroenteritis leading to vomiting and diarrhea. This can lead to dehydration, one of the most common complaints in the Pediatric Emergency Department.
- Trial name
- NCT01343758
- Testing
- 5% dextrose in normal saline
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Colorectal Cancer
C-Reactive Protein and Sodium in Predicting Anastomotic Leakage
Anastomotic leakage is serious morbidity that can develop in patients operated on for colorectal cancer and can reach potentially life-threatening dimensions.
- Trial name
- NCT04717648
- Testing
- Biochemical test
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Tepecik Training and Research Hospital
Sepsis, Gastroenteritis
Utility of Ultrasound Assessment of the Inferior Vena Cava in Patients With Sepsis and Dehydration
Conduct a randomized, controlled trial looking at how the use of ultrasound analyzing the inferior vena cava impacts the management and outcomes of pediatric emergency department patients undergoing evaluation and treatment of…
- Conditions
- Sepsis, Gastroenteritis, Dehydration
- Trial name
- NCT02568189
- Testing
- SonoSite Maxx Series Ultrasound System
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dehydration, Gastroenteritis
Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
Dehydration due to vomiting is a common complication of acute gastroenteritis in children. Persistent vomiting following rehydration is a problem in outpatient management using oral rehydration therapy.
- Trial name
- NCT00691275
- Testing
- Ondansetron, Saline
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Hyponatremia
Reexamining Hypotonic Intravenous Fluid Use
The study aim is to isolate a single type of patient (pediatric patient with acute gastrointestinal symptoms) and evaluate the use of hypotonic (0.45 NS) vs.
- Trial name
- NCT02667977
- Testing
- 0.9 Normal Saline, 0.45 Normal Saline
- Where
- United States
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Liver Cirrhosis, Hyponatremia
Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
This is a phase IV, open-label, prospective cohort study for 7 days.The recommended starting dose of tolvaptan is 15 mg daily orally.
- Trial name
- OASIS (NCT01850940)
- Testing
- Tolvaptan, conventional thearpy
- Where
- 19 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Friendship Hospital
Breast Cancer, Hypercalcemia of Malignancy
Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium
The purpose of this study is to determine the potential of denosumab to treat Hypercalcemia of Malignancy in patients with elevated serum calcium who do not respond to recent treatment with intravenous bisphosphonates by lowering…
- Conditions
- Breast Cancer, Hypercalcemia of Malignancy, Colon Cancer, Endocrine Cancer
- Trial name
- NCT00896454
- Testing
- denosumab
- Where
- 24 sites in United States, Canada and 3 more
- Volunteers
- 33 people
- Sponsor
- Amgen
Hyponatremia, Ascites
Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
- Trial name
- TONIC (NCT01716611)
- Testing
- Tolvaptan
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Konkuk University Medical Center
Dehydration, Head & Neck Cancer
DRIHNC - Dehydration Reduction in Head & Neck Cancer
The purpose of this study is to decrease the rate of visits to the Emergency Department (ED) and Acute Care Clinics (ACC) for dehydration for head \& neck (H\&N) and esophageal cancer patients that are given Gatorade while…
- Conditions
- Dehydration, Head & Neck Cancer, Esophageal Cancer
- Trial name
- NCT03799380
- Testing
- Gatorade G2, Standard of care nutritional support
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
Swallowing Disorder, Oropharyngeal Dysphagia
Effectiveness of an Optimal-Massive Intervention in Older Patients With Dysphagia
The aim of this study is to evaluate the efficacy of an optimal-massive intervention (OMI) based on increasing shear viscosity of fluids, nutritional support with oral nutritional supplements (ONS) and triple adaptation of food…
- Conditions
- Swallowing Disorder, Oropharyngeal Dysphagia, Respiratory Infection, Malnutrition
- Trial name
- OMI (NCT04581486)
- Testing
- Optimal-Massive Intervention, Control (standard clinical practice)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital de Mataró
Gastroenteritis, Vomiting
Oral Disintegrating Ondansetron Tablet to Reduce Vomiting From Gastroenteritis in a Pediatric Emergency Department
The objectives of the study were to determine whether ondansetron treatment would reduce: the amount of vomiting in the emergency department; the need for intravenous rehydration; and the need for hospitalization.
- Conditions
- Gastroenteritis, Vomiting, Diarrhea, Dehydration
- Trial name
- NCT00120744
- Testing
- Ondansetron Oral Disintegrating Tablet
- Sponsor
- The Hospital for Sick Children
Electrolyte Disturbance in Gastrointestinal Diseases
Electrolytes Disturbance in Infant
Prevalence of electrolyte disturbances in infants and children with gastrointestinal diseases
- Trial name
- NCT07152951
- Volunteers
- 150 people
- Sponsor
- Assiut University
Hypercalcemia, Familial Primary Hyperparathyroidism
Cinacalcet to Treat Familial Primary Hyperparathyroidism
This study will evaluate the benefits and side effects of a new medication called Cinacalcet for treating patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 (MEN1) or type 2A (MEN2A).
- Trial name
- NCT00325104
- Testing
- Parathyroid hormone testing, Serum calcium testing
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Dehydration, Gastroenteritis
Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan
The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children…
- Conditions
- Dehydration, Gastroenteritis, Vomiting, Diarrhea
- Trial name
- OSEP (NCT01870648)
- Testing
- Ondansetron
- Where
- 2 sites in Pakistan
- Volunteers
- 918 people
- Sponsor
- Dr. Stephen Freedman
Echinococcosis, Hepatic
Hypernatremia in Hydatid Cyst Treatment
Hypertonic saline (HS) is one of the most widely used scolocidal agents in the treatment of hydatid cysts. Hypernatremia is one of the complications associated with the use of HS.
- Trial name
- NCT05090020
- Testing
- Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Alcoholic Liver Cirrhosis, Ascites
Prevention of Decompensation in Liver Cirrhosis
The purpose of this study is to determine whether losartan, an angiotensin II blocker prevents the sodium retention in patients with liver cirrhosis and by that reduces the fluid retention.
- Trial name
- NCT00239096
- Testing
- losartan (drug)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona