Clinical trials: Electrophysiology
Autism
Behavior, Neuropsychology, Neuroimage and Electrophysiology in Autistic Individuals With and Without CNVs
The study aims to investigate whether neuropsychological function (particularly cognitive flexibility and executive function), functional (assessed by resting functional MRI, rfMRI) and structural connectivity (assessed by DSI)…
- Trial name
- NCT01582256
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation, Coronary Artery Disease
Management of New-Onset Postoperative Atrial Fibrillation
One common occurrence following open heart surgery is an irregular rhythm from the top chambers of the heart known as atrial fibrillation (afib or AF).
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Post Operative Arrythmia
- Trial name
- Monitor-AF (NCT01395836)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature
Building a Computational Model of Auditory Hallucinations
Some people hear voices or sounds that other people cannot hear; these are called auditory hallucinations. The study aims to understand what is happening in the brain when this occurs and will use brain scans to learn more.
- Conditions
- Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature, Psychosis, SCHIZOPHRENIA 1 (Disorder)
- Trial name
- CLARITY WP1 (NCT07820553)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- King's College London
Neuromuscular Blockade
The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block
The aim of this study is to investigate whether an optimized pre-treatment with intravenous magnesium enhances the speed of onset of a standard intubation dose of rocuronium.
- Trial name
- MagRoc (NCT00405977)
- Testing
- Physiologic saline, Magnesium sulphate
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Deep Brain Stimulation Surgery, Electrophysiology
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp…
- Conditions
- Deep Brain Stimulation Surgery, Electrophysiology, General Anesthesia, Consciousness, Loss of
- Trial name
- NCT06400901
- Testing
- No interventions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Equipment and Supplies
Evaluation of Accuracy and Consistency of the X-Trodes System
The purpose of this study is to evaluate the accuracy and consistency of the X-Trodes acquisition system compared to a Food and Drug Administration (FDA)-cleared clinical electrophysiology device.
- Trial name
- NCT05722639
- Testing
- X-Trodes acquisition system
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- B-Cube
Atrial Fibrillation
The Automated Calculation of AF Cycle Length and Complexity Using a Novel EP Recording System
Collect electrophysiological data during atrial fibrillation (AF) ablation procedures to assess the performance of a Signal Complexity Visualization algorithm designed to be integrated into the CathVision ECGenius® System.
- Trial name
- NCT05477602
- Testing
- Cardiac Ablation for the treatment of persistent Atrial Fibrillation
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- CathVision ApS
Healthy Volunteers, Muscle Strength
Effect of Single-Session HVPGS on Hand Grip Strength and Reaction Time in Healthy Individuals
The aim of this cross-sectional study is to investigate the immediate (acute) effects of a single session of High-Voltage Pulsed Galvanic Stimulation (HVPGS) on hand muscle strength and reaction time in healthy adults.
- Conditions
- Healthy Volunteers, Muscle Strength, Reaction Time, Neuromuscular Function
- Trial name
- NCT07745829
- Testing
- High-Voltage Pulsed Galvanic Stimulation (HVPGS)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Cardiac Arrhythmia
Oxytocin Effects on Cardiac Electrophysiology
In this pilot study the investigators will perform a double-blind randomized trial of intranasal oxytocin on measures of cardiac refractoriness, among individuals who are undergoing clinically indicated catheter ablation…
- Trial name
- NCT01780337
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- William Whang
Atrial Flutter
Radio Frequency Ablation for Atrial Flutter With Magnetic Resonance Guidance and Tracking
The Radio Frequency Ablation for Atrial Flutter with Magnetic Resonance Guidance and Tracking Pilot Study (hereafter referred to as "pilot study") is a prospective, non- randomized, single-center, pilot study.
- Trial name
- NCT02380937
- Testing
- ablation for typical atrial flutter, Vision Ablation Catheter
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University of Leipzig
Sudden Cardiac Death
Prospective Study to Identify Patients at Risk of Dangerous Ventricular Arrhythmias
The purpose of this study is to determine how well the device predicts susceptability to potentially lethal ventricular arrhythmias.
- Trial name
- HIP (NCT00562757)
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 320 people
- Sponsor
- Harbinger Medical, Inc.
Atrial Fibrillation
Enhanced Diagnostics for Early Detection of Atrial Fibrillation
Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display…
- Trial name
- DETECT-AF (NCT02270112)
- Testing
- ECG
- Where
- Switzerland
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ventricular Tachycardia, Ischemic
Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillators
The purpose of this study is to determine if early ablation (i.e., ablation of ventricular tachycardia in patients with infrequent VT episodes) is more effective than medical therapy alone for the treatment of ischemic…
- Trial name
- ASPIRE (NCT01557842)
- Testing
- Drug Treatment, Catheter Ablation
- Where
- 23 sites in United States
- Volunteers
- 15 people
- Sponsor
- Biosense Webster, Inc.
Diaphragm Dysfunction
Ultrafast Ultrasound for the Functional Assessment of the Diaphragm
The aims of the current study are as follows: i) Investigate the relationships between indices derived from ultrafast ultrasound imaging and Pditw, ii) Investigate the relationships between indices derived from ultrafast…
- Trial name
- ECHOSTIM-EFR (NCT05265351)
- Testing
- Transdiaphragmatic pressure measurement, EMG
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut de Myologie, France
Left Bundle Branch Block, Transcatheter Aortic Valve Replacement
HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients
TAVI induced LBBB is a complication that occurs between 7 and 65 % of the cases, numbers that differ considerably between devices.
- Conditions
- Left Bundle Branch Block, Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation
- Trial name
- HESITATE (NCT02659137)
- Testing
- HV measurement
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Prodromal Schizophrenia, Psychotic Episode
REtinal and VIsual Cortical Response in Early PSYchosis
The purpose of the REVIPSY study is to measure retinal and the visual cortical electrophysiological responses in situations at risk of psychosis in patients who have experienced a first psychotic episode.
- Conditions
- Prodromal Schizophrenia, Psychotic Episode, Prodromal Symptoms, Healthy Controls
- Trial name
- REVIPSY (NCT05167396)
- Testing
- Retinaute (BioSerenity), EEG Headset 64 electrodes (BioSemi), MonPackOne (Metrovision)
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centre Psychothérapique de Nancy
Schizophrenia; Psychosis
The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them
Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
- Trial name
- FRAME (NCT06375902)
- Testing
- PragmaCom
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Vagus Nerve Diseases, Epilepsy
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves.
- Conditions
- Vagus Nerve Diseases, Epilepsy, Vagus Nerve Autonomic Disorder
- Trial name
- EITsVNS (NCT05664854)
- Testing
- Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Healthy
Electrophysiological Biomarkers of AV-101
Suicide is 2-7x higher in Veterans than non-veterans, and may be related to brain kynurenine pathway (KP) dysregulation and NMDA receptor (NMDAR) hyperactivation.
- Trial name
- NCT03583554
- Testing
- AV-101 720 mg, AV-101 1440 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marijn Lijffijt, PhD
Refractory Frontal Lobe Epilepsy
Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.
Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy.
- Trial name
- NCT00382707
- Testing
- cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France