Clinical trials: Elevated Risk of Cardiovascular Disease
Acute Coronary Syndrome, Myocardial Infarction, Acute
Heart Matters: The Effectiveness of Heart Health Education in Regions at Highest-risk.
The aim of the study is to evaluate whether providing a targeted heart health education campaign to regions at high risk of heart attacks will improve ACS patient's symptom recognition and response.
- Trial name
- NCT04995900
- Testing
- Community education
- Where
- Australia
- Volunteers
- 2,240 people
- Sponsor
- Monash University
Multiple Myeloma
BCMA and CD19 Targeted Fast Dual CART for Chromosomal Abnomalities High-risk BCMA+ Multiple Myeloma
This is a single arm, open label, multi-center prospective study to explory the safety and efficacy of GC012F CAR-T cells in patient diagnosed with high-risk chromosomal abnormalities BCMA+ multiple myeloma(MM).
- Trial name
- NCT04617704
- Testing
- GC012F injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Changzheng Hospital
Pulmonary Embolism
Low Dose Thrombolysis, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism
Open label clinical randomized trial comparing three strategies for managing acute intermediate-high risk pulmonary embolism
- Trial name
- STRATIFY (NCT04088292)
- Testing
- Alteplase 20 Mg Powder for Solution for Injection Vial, Ultrasound assisted Thrombolysis
- Where
- 4 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Disease
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
This is a study to evaluate the efficacy and safety of AZD0780 in adults with clinical ASCVD or who are at risk for a first ASCVD event and who have elevated LDL-C.
- Trial name
- AZURE-LDL (NCT07000123)
- Testing
- AZD0780
- Where
- 404 sites in United States, Argentina and 20 more
- Volunteers
- 3,103 people
- Sponsor
- AstraZeneca
Blood Pressure, Sleep-Disordered Breathing
High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing.
There are data supporting a possible increase in the prevalence of High Blood Pressure (HBP) in pediatric patients with Sleep Disorder Breathing (SDB).
- Trial name
- NCT03696654
- Testing
- adenotonsillar surgery
- Where
- Spain
- Volunteers
- 286 people
- Sponsor
- Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion
Multiple Myeloma
Study of CT071 Injection in High Risk Newly Diagnosed Multiple Myeloma
This trial is a single-arm, single-center, open-label clinical trial to evaluate the safety, efficacy, and metabolism kinetics of CT071 in patients with high-risk newly diagnosed multiple myeloma.
- Trial name
- NCT06407947
- Testing
- Chimeric antigen receptor modified T cells Infusion
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Changzheng Hospital
Cardiovascular Diseases, Coronary Artery Disease
Study On Liprimar (Atorvastatin) In Patients With Coronary Heart Disease (CHD) And High Risk Of Cardiovascular Complications
In which CHD patients with high risk of CV complications are different doses of LIPRIMAR used? For this purpose, data on hyperlipidemia will be elicited over and above the basic nosographic and demographic data, concomitant…
- Trial name
- LIGHT (NCT00993915)
- Testing
- Atorvastatin
- Volunteers
- 687 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Polycythemia Vera, Essential Thrombocythemia
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Philadelphia-negative myeloproliferative neoplasms (MPN) are frequent and chronic myeloid malignancies including Polycythemia Vera (PV), essential thrombocythemia (ET), Primary Myelofibrosis (PMF) and Prefibrotic myelofibrosis…
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Prefibrotic/Early Primary Myelofibrosis, JAK2 V617F
- Trial name
- AVAJAK (NCT05198960)
- Testing
- Direct Oral Anticoagulants, Low-dose aspirin
- Where
- 42 sites in France
- Volunteers
- 1,308 people
- Sponsor
- University Hospital, Brest
Stroke
High Intensity Interval Training After Stroke
The purpose of this study is to examine if high intensity interval training after stroke is more effective than standard care to increase maximal oxygen uptake, reduce known risk factors for recurrent stroke and improve function.
- Trial name
- NCT02550015
- Testing
- High intensity interval training, General information
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Norwegian University of Science and Technology
Myocardial Ischemia
Non-isotope Based Imaging Modalities vs Technetium-99m Single-Photon Emission Computed Tomography(99mTcSPECT)
SPECT is currently the dominant clinical test for diagnostic and prognostic purposes as well as therapeutic decision-making. Given the shortage of nuclear reactor-produced Tc, advancing the use of non-isotope based imaging…
- Trial name
- MITNECB5 (NCT01972360)
- Where
- Canada
- Volunteers
- 467 people
- Sponsor
- Montreal Heart Institute
Heart Failure, Diabetes Mellitus, Type 2
Electronic Alerts for Heart Failure Prevention in Diabetes
Type 2 diabetes mellitus (T2DM) is an independent risk factor for heart failure (HF) and is associated with significant morbidity and mortality.
- Trial name
- NCT04791826
- Testing
- On-screen electronic alert
- Where
- United States
- Volunteers
- 1,524 people
- Sponsor
- University of Texas Southwestern Medical Center
Myocardial Infarction
Studying the Effectiveness of Early Invasive Treatment in Elderly Patients With High-risk Non-ST-segment Elevation Acute Coronary Syndrome.
The goal of this is observational study is to compare about MACE events and predisposing factors related to MACE events in elderly patients with high-risk non-ST acute coronary syndromes receiving early versus late invasive…
- Trial name
- NCT06486233
- Where
- Vietnam
- Volunteers
- 385 people
- Sponsor
- Gia Dinh People Hospital
Dyslipidemias, Atherosclerosis
Dyslipidemia Prevalence, Perception, Treatment, and Awareness in the Tunisian Population
ATERA Survey is a national cross sectional observational study, aiming to determine the prevalence of dyslipidemia and other conventional risk factors for CHD (Coronary Heart Disease), the relationship between environmental and…
- Conditions
- Dyslipidemias, Atherosclerosis, Households, Survey, Family Life
- Trial name
- ATERASurvey (NCT03799185)
- Where
- Tunisia
- Volunteers
- 13,610 people, healthy volunteers welcome
- Sponsor
- Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose
Atherosclerotic Cardiovascular Disease
The Learning Registry
The Learning Registry is a retrospective, exempt study. Researchers form the Duke Clinical Research Institute (DCRI) will utilize de-identified data managed by Cerner for population health analytics as part of a ongoing registry…
- Trial name
- NCT03911284
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Metabolic Syndrome
Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects
The aim of this study is to explore if a 8-weeks dietary intervention with polyphenols and omega 3 fatty acids (alone or combined) may be effective on postprandial lipids metabolism and other cardiovascular risk factors in people…
- Trial name
- Etherpaths (NCT01154478)
- Testing
- Diet rich in omega-3 fatty acids, Diet rich in polyphenols, Control diet
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Federico II University
Acute Coronary Syndrome, Heart Failure
Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)
The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Heart Failure, Influenza, Human, Cardiovascular Diseases
- Trial name
- VACC-UP (NCT07721649)
- Testing
- Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination
- Where
- 2 sites in Germany
- Volunteers
- 482 people
- Sponsor
- Stephan Baldus
Cardiovascular Disease, Hyperlipidemia
The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors.
- Trial name
- NCT01235832
- Testing
- Avocado Diet, Lower-Fat Diet, Moderate Fat Diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Penn State University
Angina, Unstable, Myocardial Infarction
Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome
To compare efficacy and safety of dalteparin compared to unfractionated heparin in patients of non ST elevation acute coronary syndromes who are planned to undergo coronary interventions (angioplasty or bypass surgery)
- Trial name
- NCT00435487
- Testing
- Dalteparin ( Fragmin), Unfractionated heparin
- Where
- 8 sites in India
- Volunteers
- 173 people
- Sponsor
- Pfizer
Symptomatic Severe Aortic Stenosis
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7
The purpose of this trial is to determine the safety and effectiveness of the Edwards SAPIEN 3 transcatheter heart valve and delivery systems which are intended for use in patients with symptomatic, calcific, severe aortic…
- Trial name
- PII S3HR/NR7 (NCT03222141)
- Testing
- TAVR Implantation of the THV Prosthesis
- Where
- 40 sites in United States, Canada
- Volunteers
- 583 people
- Sponsor
- Edwards Lifesciences
STEMI, High Risk NSTEMI
Incremental Prognostic Utility of CBC-derived Inflammatory Indices After Incomplete Coronary Revascularization: Association With 12-months Cardiovascular Outcomes
Coronary artery disease (CAD) remains the top cause of death worldwide . While guideline-directed medical therapy forms the foundation of CAD treatment , revascularization via percutaneous coronary intervention (PCI) or coronary…
- Trial name
- CBCRSS2026 (NCT07916701)
- Volunteers
- 440 people
- Sponsor
- Assiut University
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