Clinical trials: Embolism, Pulmonary
Pulmonary Embolism
The PEERLESS II Study
This study is a prospective, multicenter, randomized controlled trial of the FlowTriever System plus anticoagulation compared to anticoagulation alone for intermediate-risk acute PE.
- Trial name
- NCT06055920
- Testing
- FlowTriever System, Anticoagulation Agents
- Where
- 72 sites in United States, Belgium and 6 more
- Volunteers
- 1,200 people
- Sponsor
- Inari Medical
Pulmonary Embolism, Pulmonary Thromboembolism
The PERSEVERE Study
Randomized Controlled Trial of High-Risk Pulmonary Embolism Comparing FlowTriever System vs. Standard of Care
- Trial name
- NCT06588634
- Testing
- FlowTriever System, Standard of Care
- Where
- 33 sites in United States, France and 4 more
- Volunteers
- 200 people
- Sponsor
- Inari Medical
Acute Pulmonary Embolism
Percutaneous Mechanical Thrombectomy With or Without Low-Dose Catheter-Directed Thrombolysis in Acute Intermediate-High Risk Pulmonary Embolism
Acute pulmonary embolism (PE) is the third most common cardiovascular cause of death. In patients with intermediate-high risk acute PE, percutaneous mechanical thrombectomy (PMT) using large-bore catheters achieves rapid…
- Trial name
- PMT-LDCDT-PE (NCT07865572)
- Testing
- PMT alone (percutaneous mechanical thrombectomy only), PMT plus low-dose catheter-directed thrombolysis (PMT+LDCDT)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng
Lower Extremity Injuries, Venous Thromboembolism (VTE)
TRiP-cast Score Validation and Evaluation of Adherence to Preventive Anticoagulant Treatment in Patients With Lower Limb Trauma Requiring Immobilization
This is a prospective, multicenter, observational cohort study designed to externally validate the Trauma-Related Immobilization-related Prophylaxis (TRiP(cast)) score in Tunisian adults with acute lower-limb trauma requiring…
- Conditions
- Lower Extremity Injuries, Venous Thromboembolism (VTE), Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- TRiP-VALID (NCT07863115)
- Testing
- Low-Molecular-Weight Heparin (LMWH), Direct Oral Anticoagulants (DOACs), No Thromboprophylaxis Cohort
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Pulmonary Embolism, Pulmonary Embolism Acute Massive
Registry of Catheter Intervention in Pulmonary Embolism
Multicenter longitudinal observational ambispective (retrospective cases from 2014 and prospective from 2018 onwards) cohort study.
- Conditions
- Pulmonary Embolism, Pulmonary Embolism Acute Massive, Pulmonary Embolism Acute, Pulmonary Embolism and Thrombosis
- Trial name
- RiTEP (NCT06348459)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital San Carlos, Madrid
Pulmonary Embolism, Venous Thrombosis
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement
PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery.
- Trial name
- PEPPER (NCT02810704)
- Testing
- Enteric Coated Aspirin, Warfarin, Rivaroxaban
- Where
- 32 sites in United States, Canada
- Volunteers
- 18,883 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pulmonary Embolism
Treatment of Low-Risk Submassive Pulmonary Embolism With FlowTriever
This study is focused on investigating the efficacy and safety of the FlowTriever device to treat low-risk submassive pulmonary embolism.
- Trial name
- NCT05273762
- Testing
- FlowTriever
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Venous Thromboembolism, Active Cancer
Edoxaban Versus Apixaban in Cancer-Associated Venous Thromboembolism
This prospective, multicenter, randomized, open-label, blinded-endpoint trial aims to compare the clinical efficacy and safety of edoxaban-based treatment versus apixaban-based treatment in patients with cancer-associated venous…
- Trial name
- NEXT-CAT (NCT07852637)
- Testing
- edoxaban, Apixaban
- Where
- 12 sites in South Korea
- Volunteers
- 2,300 people
- Sponsor
- Samsung Medical Center
Venous Thromboembolism (VTE), Cancer
Vortosiran for VTE Prevention
Blood clots remain a serious cause of illness and death. Long-term treatment and prevention of these clots with blood thinners is often limited by bleeding risk, drug interactions, and daily dosing, leading many patients to stop…
- Conditions
- Venous Thromboembolism (VTE), Cancer, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07850453
- Testing
- Vortosiran
- Where
- 30 sites in Bulgaria, France and 2 more
- Volunteers
- 150 people
- Sponsor
- Ribocure Pharmaceuticals AB
Interstitial Lung Disease, Venous Thromboembolism
Risk Factors of Venous Thrombotic Event in Interstitial Lung Disease
This study aims to determine the incidence of venous thromboembolic events (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), among hospitalized patients with interstitial lung disease (ILD).
- Conditions
- Interstitial Lung Disease, Venous Thromboembolism, Pulmonary Embolism, Deep Venous Thrombosis
- Trial name
- NCT07833254
- Volunteers
- 100 people
- Sponsor
- Sohag University
Pulmonary Embolism
Home Rehabilitation After Acute Pulmonary Embolism
The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care.
- Trial name
- NCT05571189
- Testing
- Daily Activity Text, Control Text
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Rochester
Venous Thromboembolism, Cancer
Statins to Prevent Cancer Associated Blood Clots
Patients with cancer are at high risk for life-threatening venous thromboembolism (VTE) yet rarely receive anticoagulant prophylaxis due to bleeding risks.
- Conditions
- Venous Thromboembolism, Cancer, Cardiovascular Events
- Trial name
- STAT-CAT (NCT07303816)
- Testing
- Rosuvastatin
- Where
- 9 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Role of n On-contrast Chest CT (NCCT) Based CT V: Q in Patients With Acute Pulmonary Embolism (aPE)
We are doing the research to see if a CT scan without the dye can help find pulmonary emboli. If you agree to join the study, you will be asked to sign this consent form before we do any research procedures.
- Trial name
- NCT07527117
- Testing
- Additional CT acquisition at low dose (1- 2 mSv)
- Where
- 2 sites in United States
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Glial Tumors, Thrombosis
Usefulness of Thromboelastography as a Predictor of Prognosis in Patients Undergoing Surgery for Glial Tumors and of the Risk of Postoperative Thromboembolic Disease (GliTEM)
The objective of our study is to investigate the clinical significance of thromboelastometric values in the development of thrombotic events and survival in patients with glial tumors, to reduce thromboembolic complications and…
- Conditions
- Glial Tumors, Thrombosis, Pulmonary Embolism (Diagnosis)
- Trial name
- GliTEM (NCT07813377)
- Testing
- Thromboelastometry values: EXTEM CT, MCF, α-angle below the lower limit of normal. Measurement obtained after anesthetic induction. - PT, aPTT, fibrinogen, platelet count. - Thrombin generation. -
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Venous Thromboembolism, Pulmonary Thromboembolisms
Smart Technology Facilitated Patient-centered Care for Patients With Pulmonary Thromboembolism
Smart technologies, such as wearable devices, mobile technologies, and artificial intelligence, are being investigated for use in health management.
- Conditions
- Venous Thromboembolism, Pulmonary Thromboembolisms, Digital Health
- Trial name
- SmaPE (NCT06382038)
- Testing
- mobile venous thromboembolism application (mVTEA)
- Where
- China
- Volunteers
- 2,972 people
- Sponsor
- Navy General Hospital, Beijing
Venous Thromboembolism, Pulmonary Embolism
Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
While blood clots after major cancer surgery are common and harmful to patients, the medications to decrease blood clot risk are seldom used after patients leave the hospital despite the recommendation of multiple professional…
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis, Cancer
- Trial name
- NCT06451003
- Testing
- Exposure to clinical decision support system and education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Venous Thromboembolism, Venous Thromboses
inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT
After hip or knee replacement all patients receive a standardized treatment with blood thinners, this medication is called thrombosis prophylaxis.
- Conditions
- Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- DISTINCT (NCT06581965)
- Testing
- Short duration prophylaxis, Higher intensity and longer duration prophylaxis, Control
- Where
- 13 sites in Netherlands
- Volunteers
- 10,078 people
- Sponsor
- Leiden University Medical Center
Pulmonary Embolism, Embolism
Aventus Thrombectomy System Pulmonary Embolism Clinical Study
Evaluate the safety and efficacy of the Aventus Thrombectomy System for aspiration thrombectomy in subjects with acute pulmonary embolism.
- Conditions
- Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases
- Trial name
- NCT05907564
- Testing
- Thrombectomy
- Where
- 26 sites in United States
- Volunteers
- 120 people
- Sponsor
- Inquis Medical, Inc.