Clinical trials: Embolism
Deep Venous Thrombosis
Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
1. The use of LMWH following open reduction and internal fixation of ankle fractures will reduce the number of thrombi formed. 2. The rates of clinically significant DVT will be equivalent between two groups.
- Trial name
- NCT01029821
- Testing
- Low-Molecular-Weight Heparin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Adrenal Gland Hyperfunction, Cardiovascular Disease
Heart Disease Risk Factors in Major Depression
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide.
- Conditions
- Adrenal Gland Hyperfunction, Cardiovascular Disease, Involutional Depression
- Trial name
- NCT00001969
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Venous Thromboses
Intermittent Pneumatic Compression of the Upper Extremity for Post-Operative VTE Prophylaxis
Venous thromboembolism (VTE) is an important cause of morbidity and mortality following surgery.A combination of chemical and mechanical prophylaxis using lower extremity compression devices (CD) is recommended in patients who…
- Trial name
- NCT04341272
- Testing
- Intermittent Pneumatic Compression Device (FDA approved)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Pulmonary Embolism
Assessment of Right Ventricular Function After Acute Pulmonary Embolism Using Speckle Tracking Echocardiography
1. To asses regional RV function in patients presented with acute pulmonary embolism using speckle tracking echocardiography 2. To evaluate its relationship to long term mortality.
- Trial name
- NCT04609605
- Testing
- speckle tracking echocardiography
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thrombosis, Menopause
Exercise Training and Thrombotic Risk in Post-menopausal Women
At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular…
- Conditions
- Thrombosis, Menopause, Exercise Training, Vascular Dilation
- Trial name
- TIME (NCT04596501)
- Testing
- Early and late postmenopausal women
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Blood Coagulation, Platelet Function
Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation
This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.
- Trial name
- NCT02594345
- Testing
- in vitro study
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Deep Venous Thrombosis
Venous Thrombus Investigation With Contrast Enhanced Ultrasound Imaging
Background: During the repair process of deep venous thrombosis, capillary formation is seen from day 18 to day 25. Contrast agent investigation is well known to detect small vessels in arterial disease.
- Trial name
- NCT00677846
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Calcified Cerebral Embolism
Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series.
- Trial name
- CCE Cohorte (NCT06309069)
- Testing
- None, purely observational study
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Thrombosis
Safety and Tolerability Study of BMS-986177 in Healthy Subjects
The purpose of this study is to determine the safety, tolerability, and pharmacokinetics of BMS-986177 in healthy subjects
- Trial name
- NCT02608970
- Testing
- BMS-986177
- Where
- Belgium
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Thrombophilia
A Comparison of Sequential Compression Devices and Foot Pumps in the Obstetric Population
The researchers at Johns Hopkins University believe that the foot pump will be superior to sequential compression devices in comfort and patient compliance which may increase provider efforts to prevent deep vein thrombosis (DVT)…
- Trial name
- NCT00356434
- Testing
- Kendall A-V foot impulse pump, model 6060, Kendall sequential compression device, model 9525
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Venous Thromboembolism
A Two-Part Study to Assess the Safety, Tolerability, PK and PD of ONO-7684 in Healthy Adult Volunteers
This is a first in human study to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of ONO-7684 in healthy adult volunteers.
- Trial name
- NCT03919890
- Testing
- ONO-7684
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Diving Medicine, Inflammation
Inflammatory and Cerebrospinal Biochemical Markers in Blood After Trimix Diving
Research hypothesis Diving to depths up to 90msw with an oxygen partial pressure of 130kPa in the breathing gas will affect the central nervous system.
- Conditions
- Diving Medicine, Inflammation, Central Nervous System Injury
- Trial name
- TriMix17-18 (NCT03190252)
- Testing
- Exposure to oxygen partial pressure of 130 kPa, Exposure to ambient pressure of maximum 11 ATA
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Varicose Veins, MTHFR
Prevalence of MTHFR Polymorphisms in Venous Disease
The etiologies of varicose veins and the progression to more serious forms of chronic venous disease and identification of appropriate diagnostic tests to better aid patient management by identifying individuals who may benefit…
- Conditions
- Varicose Veins, MTHFR, Venous Disease, Thrombosis
- Trial name
- MTHFR (NCT01993914)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Health Diagnostic Laboratory, Inc.
Venous Thromboembolism (VTE)
Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and/or pulmonary embolism (PE), is a major public health issue.
- Trial name
- THROMPET (NCT06057844)
- Testing
- Additional blood sampling
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Acute Lymphoblastic Leukemia, Post Thrombotic Syndrome
Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Today more than 90% of children and 75% of adults (18-45 years) survive ALL.
- Trial name
- NCT04825548
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Heart Failure
Tissue Factor Expression in Stage C Heart Failure
Monocyte tissue factor (TF) was characterized in Class C heart failure (HF) vs. 25 age-matched volunteers. TF was 2.9 fold higher (p < 0.001) in HF patients vs. controls.
- Trial name
- TFHF (NCT00935740)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Utah
Lateral Sinus Thrombosis, Mastoiditis
Otogenic CSVT Retrospective Case Series and Associated Thrombophilia
The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with Otogenic Cerebral…
- Conditions
- Lateral Sinus Thrombosis, Mastoiditis, Otitis Media
- Trial name
- CSVT PCR (NCT03864055)
- Where
- Israel
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Insulin Resistance, Cardiovascular Disease
Depot-medroxyprogesterone Acetate (DMPA) Contraceptive Method and Metabolism
Objective: The purpose of this study is to determine the etiology of the weight increase in Depot-medroxyprogesterone Acetate (DMPA) users.
- Conditions
- Insulin Resistance, Cardiovascular Disease, Bone Loss, Eating Disorders
- Trial name
- DMPA (NCT01527526)
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil