Clinical trials: Embryo
Infertility
Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF)
The goal of this research study is to compare the pregnancy rates for two different types of progesterone supplementation after in-vitro fertilization (IVF).
- Trial name
- NCT00656201
- Testing
- Crinone 8% Vaginal Gel, Intramuscular Progesterone
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- Brigham and Women's Hospital
Fertility
TiLE (Time Lapse Eeva) Clinical Trial
The purpose of the study was to explore the added value of adjunctive use of Early Embryo Viability Assessment (Eeva) with morphological grading in identifying optimal embryos for transfer.
- Trial name
- TiLE (NCT02417441)
- Testing
- Eeva
- Where
- 23 sites in Canada, Denmark and 7 more
- Volunteers
- 976 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Comparing Intra-vaginal Culture of Embryos to In-vitro Culture of Embryos With Minimal Stimulation
The purpose of this study is to evaluate implantation rate with intra-vaginal culture (IVC) with the INVOcell device versus traditional In-Vitro Fertilization (IVF) while using minimal stimulation protocols
- Trial name
- NCT02802176
- Testing
- INVOcell device, Traditional IVF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Pregnancy, Multiple
eSET Plus Single Embryo Cryotransfer vs Double Embryo Transfer
The purpose of this study is to determine whether a policy of elective single embryo transfer (eSET) plus single embryo cryotransfer is as effective as a double embryo transfer in terms of clinical pregnancy rate
- Trial name
- eSET (NCT01909570)
- Testing
- Elective single embryo transfer, Double embryo transfer
- Where
- Spain
- Volunteers
- 194 people
- Sponsor
- University Hospital Virgen de las Nieves
Anxiety, Depression
Coping Intervention After Embryo Transfer
Background of the study: Undergoing an IVF or ICSI treatment is an emotional and physical burden for both the woman and her partner.
- Trial name
- NCT01701011
- Testing
- Coping intervention
- Where
- Netherlands
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Embryonic Development, Embryo Morphokinetics
Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
The purpose of this study is to investigate the development of human embryos in vitro under two different oxygen concentrations; a static 5% during all five days of culture or under an oxygen gradient, starting with 8% from day-0…
- Conditions
- Embryonic Development, Embryo Morphokinetics, Embryo Morphometry
- Trial name
- NCT05898178
- Testing
- Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
- Where
- Slovenia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Infertility
Endometrial Injury for Assisted Reproduction
The objective of this study is to evaluate the effect of endometrial injury performed prior ovulation induction for assisted reproductive techniques main outcomes.
- Trial name
- NCT01132144
- Testing
- Endometrial injury, Control group
- Where
- Brazil
- Volunteers
- 158 people
- Sponsor
- University of Sao Paulo
Infertility
Edessy ICSI Outcome Embryo Score (EIOS) Efficacy
Purpose of this study is to detect outcome of intracytoplasmic sperm injection (ICSI) according to EIOS
- Trial name
- NCT02082288
- Testing
- Edessy ICSI Outcome Embryo Score
- Where
- Egypt
- Volunteers
- 243 people
- Sponsor
- Al-Azhar University
in Vitro Fertilization
Embryo Transfer With Self-spent Culture Medium
Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the…
- Trial name
- NCT03728140
- Testing
- Self-spent Culture Medium
- Where
- China
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Bin Wu
Clinical Pregnancy After Single Embryo Transfer
Embryo Selection by Time Lapse Monitoring for Single Embryo Transfer ("SET")
A multiple pregnancy is an undesired outcome of assisted reproduction. Current embryo selection technologies are inefficient in identifying the embryo with the highest implantation potential.
- Trial name
- NCT01694641
- Testing
- time-lapse morphokinetic evaluation
- Where
- 2 sites in Hungary
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Infertility, Subfertility
Effect of hCG on Receptivity of the Human Endometrium
Worldwide, 1 in 12 couples experience difficulty in getting pregnant and seek the help of assisted reproductive technologies (ART) such as in vitro fertilization (IVF-egg is fertilized by sperm outside the body), ovarian…
- Trial name
- NCT01786252
- Testing
- human chorionic gonadotropin (hCG)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Infertility
Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
When patients undergo in vitro fertilization (IVF), they often make more embryos than it is safe to transfer back in the womb all at once. These excess embryos are frozen and stored for future use.
- Trial name
- NCT02078869
- Testing
- Progesterone in oil, vaginal progesterone suppositories
- Volunteers
- 34 people
- Sponsor
- Toronto Centre for Advanced Reproductive Technology
In Vitro Fertilization
Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
To collect the outcome of frozen-thawed embryo transfer cycles after the embryos are cryopreserved up to at least 1 year in Trial P05787 (NCT00696800), in order to estimate the cumulative pregnancy rate for each treatment group.
- Trial name
- NCT00702273
- Testing
- 150 µg Corifollitropin Alfa, 200 IU RecFSH/Follitropin beta (Days 1 to 7), 200 IU RecFSH/Follitropin beta (Days 8 to hCG)
- Volunteers
- 344 people
- Sponsor
- Organon and Co
Infertility, Female
Multicenter, Randomized, Open Label, Parallel Study to Evaluate the Efficacy & Safety of IVF-M HP Inj. vs. Menopur® Inj.
The objective of this study was to demonstrate the non-inferiority of IVFM HP Inj. by evaluating its efficacy versus Menopur® Inj.
- Trial name
- NCT02458768
- Testing
- IVF-M HP Inj., Menopur® Inj.
- Volunteers
- 112 people
- Sponsor
- LG Life Sciences
Infertility
MENOPUR in Gonadotrophin-releasing Hormone (GnRH) Antagonist Cycles With Single Embryo Transfer
The main purpose of this clinical research trial was to compare the ongoing pregnancy rate between two gonadotrophins for controlled ovarian stimulation (MENOPUR and recombinant follicle-stimulating hormone (FSH)), in cycles…
- Trial name
- MEGASET (NCT00884221)
- Testing
- Highly purified menotrophin, Recombinant FSH
- Where
- 25 sites in Belgium, Czechia and 5 more
- Volunteers
- 749 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Female
The Application of Zishen Yutai Pill in Aged Women Undergoing IVF-ET
To explore the application of Zishen Yutai Pill in controlled ovarian stimulation and effect on pregnancy outcome in aged women undergoing in vitro fertilization-embryo transfer.
- Trial name
- NCT03703700
- Testing
- Zishen Yutai Pill
- Where
- 12 sites in China
- Volunteers
- 1,467 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Aneuploidy
Single Embryo TrAnsfeR of Euploid Embryo
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a…
- Trial name
- STAR (NCT02268786)
- Testing
- Preimplantation Genetic Screening by NGS
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 661 people
- Sponsor
- Illumina, Inc.
Embryonic Mosaicism, Embryo Culture Media
Media, Morphokinetics, and Mosaicism
Embryonic aneuploidy is the underlying etiology for the majority of failed implantation and miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has been advocated as a strategy for increasing…
- Conditions
- Embryonic Mosaicism, Embryo Culture Media, Embryo Morphokinetics, Infertility
- Trial name
- 3M (NCT03503877)
- Testing
- EmbryoScope Plus, GLOBAL MEDIA, SAGE MEDIA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Cancer, Infertility
RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
The purpose of this study is to compare two different ways to administer Letrozole to determine their effectiveness in blocking estrogen production during ovarian stimulation in patients with breast cancer prior to…
- Trial name
- NCT01035099
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Age-Related Macular Degeneration
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
The main objective of the study is evaluation of the safety and tolerability of OpRegen - Human embryonic stem cell-derived retinal pigment epithelial (RPE) cells.
- Trial name
- NCT02286089
- Testing
- OpRegen
- Where
- 7 sites in United States, Israel
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche