Clinical trials: Embryo Disorder
Infertility
Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
- Trial name
- NCT00680238
- Testing
- Human derived FSH
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Infertility
Hyaluronan in Embryo Transfer Media
Prospective randomized double blind comparison of hyaluronan enriched embryotransfer media and conventional embryotransfer media in human IVF treatments.
- Trial name
- NCT02077608
- Where
- Hungary
- Volunteers
- 580 people
- Sponsor
- Peter Fancsovits, Ph.D.
Infertility
Perifollicular Vascularity Assessment in in-Vitro Fertilization
On February 2004, a law (n. 40/2004) regulating assisted reproduction techniques (ARTs) was approved in Italy. This law aimed to regulate the treatment of infertility in Italy, contains several restrictions, such as the…
- Trial name
- NCT00458380
- Testing
- Controlled ovarian stimulation, perifollicular vascularity assessment, IVF, embryo transfer.
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University Magna Graecia
Infertility
Diafert® for Embryo Selection and Fertility Improvement
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02593461)
- Testing
- Daifert, Control Group
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Forest Laboratories
Infertility (IVF Patients)
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
The goal of this multicenter, randomized, placebo-controlled, double-blind clinical trial is toto evaluate the efficacy and safety of a human menopausal gonadotropin (hMG) in the development of multiple follicles, pregnancy, and…
- Trial name
- GRACE (NCT07216742)
- Testing
- hMG subcutaneous injection
- Where
- 16 sites in United States
- Volunteers
- 659 people
- Sponsor
- Granata Bio Corporation
Infertility
Adding Cytokines to In Vitro Human Culture Media to Improve Embryogenesis and Implantation
Assessment of the embryological benefit of in vitro adding of Cytokines (LIF 5ng/ml, HB-EGF 5ng/ml and GM-CSF 2n/ml) to the culture media and closely monitor its effect on embryogenesis and implantation outcomes.
- Trial name
- GHLCSHED (NCT02420886)
- Testing
- Adding LIF, HB-EGF and GM-CSF to Lifeglobal human IVF culture media
- Where
- 2 sites in Egypt
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Infertility
Comparing Two Different Embryo Transfer Catheters
Numerous published trials now document that the embryo transfer (ET) procedure has a huge impact on pregnancy and delivery rates after IVF (In Vitro Fertilization).
- Trial name
- CATH (NCT03161119)
- Testing
- Ultrasound guided embryotransfer with Cook K-Jets-551910-S, Ultrasound guided embryotransfer with Cook k-soft-5000 (or K-J-SP-681710 and K-J-SPPE-681710)
- Where
- Italy
- Volunteers
- 352 people
- Sponsor
- Istituto Clinico Humanitas
Endometrioma
Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients
Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients
- Trial name
- GnRh (NCT02737800)
- Testing
- endometrioma aspiration, GnRh agonist ( Decapeptyl ), standard long stimulation protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
Infertility
Comparison of Frozen-thawed Embryo Transfers and Fresh Embryo Transfers With Whole Chromosome Analysis Using Next Generation Sequencing
The investigators propose to perform a clinical randomized trial to evaluate the effect of a frozen-thawed embryo transfer and a fresh embryo transfer on pregnancy and implantation rates; with the added benefit of a blastocyst…
- Trial name
- NCT02000349
- Testing
- PGD
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Reprogenetics
Infertility
Randomized Trial Comparing EmbryoScope With EmbryoScope+.
The purpose of the study is to compare the current EmbryoScope Time-Lapse System being used in IVF which has become standard of care to the new model EmbryoScope to demonstrate that the EmbryoScope+ is as safe and reliable as the…
- Trial name
- NCT03522350
- Testing
- EmbryoScope, EmbryoScope+
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Weill Medical College of Cornell University
Embryo Transfer, IVF
Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
The aim of this work was to investigate the effect of different vasodilators as pentoxifylline in women with unexplained infertility using IVF
- Conditions
- Embryo Transfer, IVF, Infertility
- Trial name
- NCT07499817
- Testing
- pentoxifylline 400 mg, (control)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Infertility
Three-dimensional Versus Two-dimensional Ultrasound Guided Embryo Transfer in Women Undergoing ART Treatment
Objectives: To assess whether embryo transfer guided by three-dimensional ultrasound (3DUS) produces a significantly higher clinical pregnancy rate than embryo transfer guided by two-dimensional ultrasound (2DUS).
- Trial name
- NCT02413697
- Testing
- Two-dimensional ultrasound, Three-dimensional ultrasound
- Where
- Hong Kong
- Volunteers
- 481 people
- Sponsor
- Chinese University of Hong Kong
Infertility
Frozen Embryo Transfer in Natural and Hormonal Replacement Cycles
This study is a prospective randomized controlled trial to compare the pregnancy outcomes of frozen embryo transfer in natural and hormonal replacement cycles.
- Trial name
- NCT02251925
- Testing
- frozen Embryo transfer, 10,000U hCG injection, GnRH agonist (Superfact)
- Where
- Iran
- Volunteers
- 460 people
- Sponsor
- Royan Institute
Stem Cell Transplant Complications, Skin Inflammation
Very Small Embryonic-like Stem Cells for Facial Skin Antiaging
The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to facial skin antiaging.
- Trial name
- NCT03976206
- Testing
- Very small embryonic-like stem cell
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
Improving IVF Embryo Quality Grading Using Polarized Light
Selecting one or two IVF embryos with the highest potential to implant is extremely important for the success of the treatment- obtaining pregnancies and avoiding multi-fetal gestations.
- Trial name
- NCT01601249
- Testing
- Embryo selection based on polscope grading or morphology
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Infertility
Oocyte Cryopreservation: Slow Cooling Versus Vitrification Techniques on Oocyte Survival
Oocyte cryopreservation has been studied for many years without much success in refining a method that has consistent, reliable results in producing viable embryos and clinical pregnancies.
- Trial name
- NCT00602966
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- UConn Health
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Poor Response to Ovulation Induction, Infertility, Female
Optimal Embryonic Stage for Transfer in Poor Responders
A Prospective cohort study including couples with poor responder females who undergoing ICSI
- Trial name
- NCT04485819
- Testing
- Cleavage stage transfer, Blast stage transfer
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital