Clinical trials: Emotional Instability
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Attention Deficit Hyperactivity Disorder
Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD
The aim of this study is to examine the mechanisms by which stimulant medications reduce symptoms in patients with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01415440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Bereavement, Depressive Disorder
Consequences of Conjugal Bereavement in Adults
Bereavement refers to the expected reactions and sadness associated with the loss of a loved one. It has been reported that the loss of a spouse is rated as the major life stressor among survivors of varying ages and diverse…
- Conditions
- Bereavement, Depressive Disorder, Immunologic Disease, Mental Disorder
- Trial name
- NCT00001659
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Irritable Aggression
Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings
Though the Disruptive Disorders of Childhood and Adolescence are a major source of morbidity and fill a large proportion of special education slots, specific pharmacologic treatment is available only for those children with…
- Trial name
- NCT02078596
- Testing
- Divalproex
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease, Agitation
Citalopram for Agitation in Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of citalopram for agitation in Alzheimer's dementia.
- Trial name
- CitAD (NCT00898807)
- Testing
- citalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- JHSPH Center for Clinical Trials
Hot Flashes, Night Sweats
Comparison of Hormonal Therapy: Mediating Hot Flashes Tapering Regimens for Mediating Hot Flashes
This study will evaluate whether there is a difference in the proportion of women who report a worsening severity of their hot flashes between three tapering schedules for one accepted HT/ET regimen.
- Trial name
- NCT00547001
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Attention Deficit Hyperactivity Disorder (ADHD)
The Relationship of Essential Fatty Acids to Adult ADHD: The OCEAN Study (Oils and Cognitive Effects in Adult ADHD Neurodevelopment)
Brief summary The aim of the study is to provide preliminary data on the relationship of Essential Fatty Acids (EFAs) to cognitive and electrophysiological measures of brain and behavioural functions in adults with attention…
- Trial name
- OCEAN (NCT01750307)
- Testing
- Experimental fatty acid supplementation
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Perinatal Problems, Mood Change
Investigating a Probiotic on Mothers' Mood and Stress
This is a randomized, placebo-controlled, double-blind, 3 parallel-arm study in pregnant women aged 21 years old and above. The study aims to assess changes in perinatal mood and stress when administering a probiotic starting…
- Conditions
- Perinatal Problems, Mood Change, Stress-related Problem
- Trial name
- NCT04685252
- Testing
- (BL) NCC3001
- Where
- Singapore
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Bipolar Disorder I or II, Healthy (Controls)
Decoding Emotional Dynamics in Bipolar Disorder
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability.
- Trial name
- NCT07221864
- Testing
- Think and Regulate Affective State Task
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Non-Muscle Invasive Bladder Cancer
Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG
The purpose of this study is to evaluate mood changes in patients with Non-Muscle Invasive Bladder Cancer who are receiving intravesical Bacillus Calmete-Guerin (BCG).
- Trial name
- NCT05672615
- Testing
- Questionnaires, Daily Mood Diaries, Urine Specimen Collection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Atherosclerosis, Coronary, Emotional Stress
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood.
- Conditions
- Atherosclerosis, Coronary, Emotional Stress, Inflammation, Hematopoiesis
- Trial name
- NCT04853511
- Testing
- OCT-FLIM (optical coherence tomography-fluorescence life time)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Bipolar Affective Disorder
Compassion-Focused Therapy for Distressing Mood Swings: A Case Series
The goal of this case series is to investigate whether a brief compassion-focused intervention is a safe, acceptable and feasible therapy for clients with bipolar affective disorder.
- Trial name
- NCT05860101
- Testing
- Compassion-Focused Therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Institute of Psychiatry, London
Bipolar Disorder
N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I…
- Trial name
- SMRI-Bipolar (NCT01797575)
- Testing
- Aspirin, N-acetyl-cysteine (NAC), Sugar Pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston
Mood Disturbance, Mood Change
Mood and Cognitive Effects of Psilocybin in Healthy Participants
This study is seeking to find the optimal microdose or low dose of psilocybin (magic mushrooms) that provides general enhancements to mood, memory, sleep, and other measures of general well-being without any hallucinogenic…
- Conditions
- Mood Disturbance, Mood Change, Sleep Disturbance, Drug Effect
- Trial name
- MELO (NCT05252598)
- Testing
- Psilocybin, Inonotus Obliquus Whole Extract
- Volunteers
- healthy volunteers welcome
- Sponsor
- Optimi Health Corporation
Knee Osteoarthritis, Degenerative Joint Disease
Milnacipran for Chronic Pain in Knee Osteoarthritis
The patients are asked to take part in this study because you have chronic pain as a result of knee osteoarthritis. This study is done to investigate the pain relieving effects of the study drug Savella (milnacipran HCl) for…
- Conditions
- Knee Osteoarthritis, Degenerative Joint Disease, Chronic Pain
- Trial name
- KOA (NCT01510457)
- Testing
- Milnacipran
- Volunteers
- 46 people
- Sponsor
- Dr. Norman Harden
Memory Deficits, Aging
The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and…
- Conditions
- Memory Deficits, Aging, Cognitive Impairment, Physical Activity
- Trial name
- NCT05363228
- Testing
- Therapy by Dance and Movement, Tai Chi
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic