Clinical trials: End-Stage Kidney Disease
Renal Disease, End Stage
β2M Post-HD Rebound Prediction
β2-Microglobulin is small 11.8 kDa protein presents on the surface of all nucleated cell in the human body, it forms part of the non-variable chain of Major Histocompatibility Complex class I.
- Trial name
- NCT07713680
- Testing
- β2-microglobulin blood concentration in mg/L
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- East and North Hertfordshire NHS Trust
End-Stage Renal Disease
Study on the Safety and Efficacy of a Time-of-Day-Based Individualized Tacrolimus Dosing Regimen in Kidney Transplant Recipients
The goal of this clinical trial is to evaluate whether chronopharmacokinetic model-guided individualized unequal twice-daily tacrolimus dosing improves renal allograft function and reduces acute rejection in stable kidney…
- Trial name
- NCT07877103
- Testing
- Chronotherapy-based individualized low-morning high-evening tacrolimus dosing, conventional dosing regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
End-Stage Kidney Disease, End-Stage Renal Disease
CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved…
- Trial name
- BRAVO (NCT05931276)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 18 sites in United States
- Volunteers
- 2,540 people
- Sponsor
- VA Office of Research and Development
End-Stage Renal Disease
REFLEXOLOGY AND SLEEP HYGIENE IN HEMODIALYSIS TREATMENT (HD)
Sleep problems are common in people undergoing dialysis treatment due to kidney failure. Methods other than medication can be used to improve this condition.
- Trial name
- HD (NCT07518628)
- Testing
- Reflexology
- Where
- 2 sites in Cyprus
- Volunteers
- 60 people
- Sponsor
- Kibrıs Aydin Üniversitesi
End-Stage Kidney Disease (ESKD)
Virtual Reality-Guided Imagery in Hemodialysis Patients ( VRGI-HD )
This randomized controlled trial aims to evaluate the effect of virtual reality guided imagery on selected health outcomes among adult patients receiving maintenance hemodialysis.
- Trial name
- NCT07867444
- Testing
- virtual reality-guided imagery (VRGI)
- Volunteers
- 80 people
- Sponsor
- Islamic University of Najaf
End Stage Renal Disease (ESRD), Kidney Failure
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
The goal of the CSP-2002 clinical trial is to evaluate the safety and effectiveness of the InnAVasc Arteriovenous Graft (IG) for hemodialysis (HD) access in patients with end-stage renal disease (ESRD).
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
- Trial name
- NCT04671771
- Testing
- InnAVasc Arteriovenous Graft (IG) surgical implant
- Where
- 22 sites in United States
- Volunteers
- 133 people
- Sponsor
- W.L.Gore & Associates
End Stage Kidney Disease
Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients.
- Trial name
- ISO-UF (NCT05642156)
- Testing
- isolated Ultrafiltration (iso-UF)
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Graz
Tuberculosis (TB), End-Stage Kidney Disease
Evaluation of IGRA, Symptoms and Chest Radiograph for Subclinical TB Detection in ESRD and KT
This is an observational study among approximately 160 end-stage renal disease patients on renal replacement therapy and post-living donor or deceased donor kidney transplant recipients.
- Trial name
- NCT06700876
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University
End Stage Renal Disease (ESRD), Volume Overload
Blood Volume Monitoring Via Critline in Volume Overload: Hospitalization and Readmission
The investigators are examining how adding relative blood volume monitoring (RBVM) to the best clinical practice affects outcomes (length of stay and rehospitalization) among dialysis patients hospitalized for or with volume…
- Trial name
- NCT07866872
- Testing
- Relative Blood Volume Monitoring (RBVM)
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
End Stage Kidney Disease
Virtual Reality in End Stage Kidney Disease
The goal of this clinical trial to compare the social virtual reality and individual virtual reality in patients with end stage kidney disease who are hemodialysis.
- Trial name
- NCT06356168
- Testing
- Social Virtual Reality, Individual Virtual Reality
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pennsylvania
Complication of Renal Dialysis, End Stage Renal Disease
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at the time of surgical creation of an…
- Conditions
- Complication of Renal Dialysis, End Stage Renal Disease, End Stage Kidney Disease, ESRD
- Trial name
- ACCESS2 (NCT05425056)
- Testing
- Sirolimus
- Where
- 22 sites in United States, United Kingdom
- Volunteers
- 136 people
- Sponsor
- Vascular Therapies, Inc.
End-Stage Kidney Disease (ESKD)
Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants With End-Stage Kidney Disease on Hemodialysis
This study will evaluate three Investigational Medicinal Products (IMPs) called REGN9933, REGN7508, and REGN9533. The study is focused on participants with End-Stage Kidney Disease (ESKD) treated with hemodialysis and standard…
- Trial name
- NCT07759167
- Testing
- REGN9933, REGN7508, REGN9533
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Regeneron Pharmaceuticals
End-Stage Kidney Disease, Peritonitis
Check List to Improve Patient Self-care and Product Defect Report in Continuous Ambulatory Peritoneal Dialysis
Peritoneal Dialysis (PD) has been the main method of treatment for Thai End-Stage Renal Disease (ESRD) patients under the "PD First" policy of the Universal Coverage (UC) scheme.
- Trial name
- CLIP-SP (NCT02755610)
- Testing
- PD Product Check List
- Where
- Thailand
- Volunteers
- 880 people
- Sponsor
- Chulalongkorn University
End Stage Renal Disease
Intravascular Ultrasound in Patients With End-stage Renal Disease on Dialysis
Hemodialysis represents a life line of patients with end stage renal disease, who are commonly maintained on hemodialysis through catheters.
- Trial name
- IVUS in ESRD (NCT04399941)
- Testing
- Venography, Intravascular ultrasound (IVUS), Image processing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Medical Center
End Stage Renal Disease
Solv Multi-Pass Hemodialysis System In-Center Clinical Study
Solv In-Center clinical study is a pre-market, prospective, multicenter, single arm, open-label clinical study. The patient population will include patients with kidney failure or insufficiency requiring hemodialysis and/or…
- Trial name
- NCT07216885
- Testing
- Solv Multi-Pass Hemodialysis System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mozarc Medical US LLC
End Stage Renal Disease, Renal Impairment
A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide
The primary objective of the study is to estimate the PK parameters of ribupatide in participants with severe renal impairment or end-stage kidney disease (ESKD) after a single dose of ribupatide subcutaneous (SC) injection…
- Conditions
- End Stage Renal Disease, Renal Impairment, Obesity, Overweight
- Trial name
- NCT07793929
- Testing
- Ribupatide
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kailera
Kidney Disease, Kidney Failure
A Retrospective Multicenter Study to Determine 5-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-01 Study
This study is a multicenter, non-randomized, retrospective study to collect long term (5 years post-transplant) clinical outcome data to test whether the results of the noninvasive immune monitoring test strategy performed in the…
- Conditions
- Kidney Disease, Kidney Failure, End Stage Renal Disease
- Trial name
- NCT01974999
- Where
- 7 sites in United States, Canada
- Volunteers
- 184 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Disease Requiring Hemodialysis, End-Stage Kidney Disease (ESKD)
DIALysis With EXpanded Solute Removal
The goal of this clinical trial is to evaluate the health effects of expanded hemodialysis in patients receiving hemodialysis. The main question it aims to answer is: 1) Does expanded hemodialysis reduce the risk of death from…
- Conditions
- Chronic Kidney Disease Requiring Hemodialysis, End-Stage Kidney Disease (ESKD), Chronic Kidney Disease Requiring Chronic Dialysis, Pragmatic Randomized Controlled Trial
- Trial name
- DIALEX (NCT06660277)
- Testing
- Super High-Flux Dialyzer, High-Flux Dialyzer
- Where
- 3 sites in Canada
- Volunteers
- 4,800 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End-Stage Renal Disease Requiring Haemodialysis
Effects of Supervised Exercise Training on Erythrocyte Deformability in Hemodialysis Patients
This study evaluated red blood cell function and aerobic capacity in adults receiving maintenance hemodialysis and in healthy reference participants.
- Trial name
- NCT07836881
- Testing
- Supervised Exercise Training
- Where
- Taiwan
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Asia University
End Stage Renal Disease, Chronic Kidney Diseases
Shared Decision Making in Dialysis
Older patients ≥65 years with chronic kidney disease (CKD) face challenges in decision making about dialysis. These patients report little effort by physicians to elicit treatment preferences, discuss prognoses, or explain the…
- Trial name
- DIAL-SDM (NCT04392440)
- Testing
- DIAL-SDM, usual care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Rochester