Clinical trials: Endarterectomy, Carotid
Coronary Stenosis
Trial Comparison of Accuseal and Bovine Pericardial Patch During Endarterectomy
Carotid Endarterectomy (CEA), surgical removal of the blockage in the neck artery, is the accepted management of choice for significant blockage of the carotid artery.
- Trial name
- NCT01184183
- Testing
- Comparing Accuseal Vs. Bovine Pericardial in CEA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Transient Ischemic Attack, Carotid Stenosis
EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis
The purpose of this study is to evaluate whether carotid angioplasty with stent (CAS) is as safe and effective as carotid surgery in regards to: 1. the risk of stroke and death within 30 days of the procedure; 2.
- Conditions
- Transient Ischemic Attack, Carotid Stenosis, Atherosclerosis
- Trial name
- NCT00190398
- Testing
- Carotid angioplasty and stenting with cerebral protection
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Artery Diseases
Postapproval Trial On Carotid Stenting in Patients With High Risk Vs Standard Risk for Open Carotid Endarterectomy(REAL)
Until the irruption of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST), carotid stenting (CAS) has been mainly offered to those patients considered at "high risk" for open carotid endarterectomy (CEA)…
- Trial name
- REAL (NCT02750644)
- Volunteers
- 125 people
- Sponsor
- Joaquin de Haro, M.D.
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Carotid Artery Disease, Carotid Stenosis
Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)
The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke, Atherosclerosis
- Trial name
- ACT I (NCT00106938)
- Testing
- Carotid artery stenting with filter (interventional), Carotid artery endarterectomy (surgical)
- Where
- 62 sites in United States
- Volunteers
- 1,663 people
- Sponsor
- Abbott Medical Devices
Carotid Stenosis
Histological Validation Of Carotid Plaque Composition In Preoperative Imaging
Patients scheduled for carotid endarterectomy undergo preoperative imaging to assess vulnerable plaque. The imaging modalities include (in various combinations at different study sites) 3-dimensional ultrasound, PET/CT imaging…
- Trial name
- NCT01456403
- Testing
- Histological validation
- Where
- 3 sites in Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hemodynamic Stability
Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane
The purpose of this study is to compare the hemodynamics effects of two usual hypnotic agents (LENOXe ™ (xenon 100 % v/v) and sevoflurane) during a general anesthesia for carotid endarterectomy in elderly patients.
- Trial name
- NCT00937807
- Testing
- xenon, sévoflurane
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Air Liquide Santé International
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Carotid Artery Diseases, Peripheral Artery Disease
Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG
From our experience among Egyptian population in our institution, there is an increased prevalence of hidden subclinical peripheral artery disease along with carotid artery affection.
- Trial name
- NCT03516929
- Testing
- carotid duplex, both LL arterial duplex
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Mr Ihab Ali
Carotid Endarterectomy (CEA) Surgical Patients
Ultrasound Evaluation for Baxter VASCU-GUARD Vascular Patches Post-Endarterectomy and Complications Assessment
VASCU-GUARD vascular patches with the new packaging have been available at the Houston Methodist Hospital since January 2023. This study is a retrospective chart review, aiming to compare the performance of Baxter VASCU-GUARD…
- Trial name
- VASCU-GUARD (NCT07048067)
- Testing
- Carotid endarterectomy (CEA)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Methodist Hospital Research Institute
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy
SONOBIRDIE Trial is a randomized, single-blind, sham-controlled study designed for a demonstration of the safety and effectiveness of sonolysis (continual transcranial Doppler (TCD) monitoring) in reduction of risk of stroke or…
- Trial name
- SONOBIRDIE (NCT02398734)
- Testing
- sonolysis
- Where
- Czechia
- Volunteers
- 1,492 people
- Sponsor
- University Hospital Ostrava
Carotid Artery Diseases, Coronary Artery Disease
Outcome of LA Versus GA for Staged CEA Prior To CABG
A retrospective analysis of all patients that underwent carotid endarterectomy (CEA) for stenotic disease - diagnosed at pre-operative investigation - prior to CABG as staged operation within 6- months.
- Conditions
- Carotid Artery Diseases, Coronary Artery Disease, Stroke
- Trial name
- NCT04901000
- Testing
- Carotid endarterectomy
- Volunteers
- 44 people
- Sponsor
- Thomas Aherne
Cerebral Hypoxia, Carotid Stenosis
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their…
- Conditions
- Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
- Trial name
- NCT05652426
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duzce University
Stroke
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks.
- Trial name
- EVA3S-2 (NCT07054060)
- Testing
- carotid endarterectomy, Carotid artery stenting
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Anne
Carotid Stenosis
Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients
The trial randomise patients with asymptomatic carotid artery narrowing in whom prompt physical intervention is thought to be needed, but there there is still substantial uncertainty shared by patient and doctor about whether…
- Trial name
- ACST-2 (NCT00883402)
- Testing
- CEA, CAS
- Where
- 125 sites in United States, Austria and 30 more
- Volunteers
- 3,638 people
- Sponsor
- University of Oxford
Carotid Stenosis
A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy
The primary aim of this protocol is to investigate a possible new, neuroprotective treatment to prevent cognitive deficits that occur after carotid endarterectomy.
- Trial name
- NCT00401921
- Testing
- Minocycline
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Choroid, Carotid Stenosis
Ocular Effects of Carotid Endarterectomy
All patients undergoing carotid endarterectomy in Shaare Zedek Medical Hospital, during about 1 year, will be offered to participate. Retinal and choroidal structural changes will be assessed using swept-source OCT technology
- Conditions
- Choroid, Carotid Stenosis, Carotid Endarterectomy
- Trial name
- NCT02448355
- Testing
- OCT swept source DRI-Atlantis, Topcon
- Volunteers
- 30 people
- Sponsor
- Shaare Zedek Medical Center
Atherosclerosis
Early Therapeutic Effects of Statins and Fibrates on Unstable Atherosclerotic Plaques
Rupture of unstable atherosclerotic plaques is the underlying pathophysiologic mechanism of acute coronary syndromes and thus also of perioperative myocardial ischemia.
- Trial name
- NCT00243672
- Testing
- Atorvastatin, Gemfibrozil
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Stenoses, Carotid, Stroke
Anatomical Relationship Between Carotid Artery and Hyoid Bone in Stenotic and Non-stenotic Carotids
Ischaemic stroke is attributable to thromboembolism caused by carotid atherosclerotic disease in 18-25% of patients. Guidelines for prevention of stroke (especially carotid endarterectomy) in patients with carotid atherosclerotic…
- Trial name
- CAROTHYD (NCT05349526)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Carotid Endarterectomy
Monitoring Brain Perfusion and Cerebral Oximetry in Carotid Endarterectomy Surgeries
The goal of this study is to demonstrate Or-Nim's CerOx monitor ability to monitor changes in cerebral blood flow and oximetry during CEA surgery.
- Trial name
- CerOx (NCT02102386)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine