Clinical trials: Endocrine Disorder
Pancreatic Cancer
Vitamin E δ-Tocotrienol Multiple Dose in Healthy Subjects
The Principal Investigator believes that Vitamin E δ-Tocotrienol will slow the progression of pancreatic cancer cells. Therefore, the investigators must determine the safety and tolerability of Vitamin E δ-Tocotrienol in healthy…
- Trial name
- NCT01450046
- Testing
- Vitamin E δ-Tocotrienol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hypogonadism, Osteopenia
Testosterone and Alendronate in Hypogonadal Men
This study will investigate the hypothesis that the combination of testosterone replacement and alendronate will improve bone density and parameters of bone quality more than either medication alone in older men with low…
- Conditions
- Hypogonadism, Osteopenia, Osteoporosis
- Trial name
- NCT01460654
- Testing
- Testosterone, Alendronate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Obesity, Diabetes Mellitus, Type 2
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
The purpose of this study is: 1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2.
- Trial name
- BARIA-DDZ (NCT01477957)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Gestational Diabetes Mellitus
FGF19 and the Expression of IRS-1 and GLUT-1 in Gestational Diabetes Mellitus
Insulin resistance plays a key role in the development of gestational diabetes mellitus(GDM). As the largest endocrine organ and the transport intermediary of maternal-fetal nutrient and a large of hormone and enzymes, placenta…
- Trial name
- NCT03816605
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Diabetes Mellitus, Type 2, Sedoanalgesia
The Effect of Diabetes Mellitus in Colonoscopy Under Sedoanalgesia
INTRODUCTION AND AIM Diabetes Mellitus (DM) is a common endocrine disease in the world. Colon polyps and colorectal cancers are reported more in DM patients.
- Trial name
- NCT04477694
- Testing
- colonoscopy under sedoanalgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baskent University
Non Small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT03551951
- Testing
- Test for circulating tumor cells, DNA alterations
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Breast Cancer, Ovarian Cancer
Guilford Genomic Medicine Initiative (GGMI)
Genomic medicine, using genetic information to improve health outcomes, is heralded as the answer to rising medical costs by focusing on prevention and tailored care.
- Conditions
- Breast Cancer, Ovarian Cancer, Colon Cancer, Thrombophilia
- Trial name
- GGMI (NCT01372553)
- Where
- United States
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- The Moses H. Cone Memorial Hospital
Diabetes Mellitus Type 2
Adipose Tissue Imaging in Type 2 Diabetes
The metabolic function of different white adipose tissue depots in the body and its role in the development of type 2 diabetes (T2D) remains unclear.
- Trial name
- ATI-DM2 (NCT02528695)
- Testing
- 18F-FDG PET/CT, euglycemic clamp, hypoglycemic clamp
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Insulin-Dependent
Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer
This study will evaluate the safety and effectiveness of a continuous glucose monitor in children with Type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00069628
- Testing
- GlucoWatch® G2™ Biographer (GW2B), Continuous Glucose Monitoring System (CGMS)
- Where
- 6 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Diabetes, Hypertension
Survey of Thai-Muslim Health Status
The purpose of this study was to determine the prevalence and risk factors of diabetes, hypertension, hyperlipidemia among Thai muslim population aged 35-75 years.
- Conditions
- Diabetes, Hypertension, Hyperlipidemia
- Trial name
- NCT00701454
- Testing
- No intervention
- Where
- Thailand
- Volunteers
- 1,488 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Obesity, Diabetes
Comparison of Pulse Chips and Commercial Snacks on Food Intake, Appetite and Blood Glucose in Healthy Young Adults
Consumers are often forced to eat fast, convenient foods and snacks ("eat on the go") in order to match the pace of their lifestyles. However, these snack options more often than not offer little health benefit to the consumer.
- Trial name
- NCT03297931
- Testing
- Corn Chips + Onion Dip, Yellow pea chip + hummus, Pinto bean chip + hummus
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pregnancy, Gestational Diabetes
Behavior of Biomarkers During Pregnancy and Lactation Through a Biological Multi-paradigm Model: BECOME Study Protocol
Background Despite of advances in research, at the moment, various points related to the physiology of gestation and the etiology of severe diseases that can be developed in the course of it remain unknown.
- Conditions
- Pregnancy, Gestational Diabetes, Hypertension, Obesity
- Trial name
- BECOME (NCT02811172)
- Testing
- BEhavior of biomarkers during pregnanCy and lactatiOn
- Where
- Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Pancreatic Cancer
Role of the Cystic Fluid Interleukins and Tumor Necrosis Factor (TNF) Levels in Characterizing Pancreatic Cysts Detected by Endoscopic Ultrasound (EUS)
This study aims to find a correlation between cytokines levels and malignancy potential of different cystic types.
- Trial name
- NCT03178812
- Testing
- EUS with fine-needle aspiration of pancreatic cyst, Laboratory Blood test
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Diabetic Retinopathy
Restoration of Retinal Vascular Responses in Type 1 Diabetic Patients
Diabetic retinopathy is the leading cause of blindness in the developed world. The causes of the disease are poorly understood. One of the earliest changes that occur in the retinas of diabetic patients, well before overt…
- Trial name
- NCT02099981
- Testing
- Aminoguanidine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Ovarian Diseases, Ankylosing Spondylitis
Ovarian Reserve and Ankylosing Spondylitis
The aim of this study was to determine the status of ovarian reserve in patients with ankylosing spondylitis (AS) using anti-mullerian hormone (AMH) level and antral follicle count (AFC).
- Conditions
- Ovarian Diseases, Ankylosing Spondylitis, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04209881
- Testing
- ovarian reserve for Ankylosing spondylitis and control groups
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
Study of Carrageenan's Effect on Insulin Resistance in Humans
The purpose of this study is to determine whether the ingestion of the common food additive carrageenan contributes to insulin resistance and thus to the pathogenesis of type 2 diabetes in humans.
- Trial name
- NCT02629705
- Testing
- Carrageenan
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes Mellitus
Bioequivalence Study of Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR (Extended-release) and Dapagliflozin / Metformin XR Relative to Individual Components in Healthy Subjects
In this integrated, Phase I study, the safety, tolerability, food effect, and pharmacokinetic (PK) properties of Fixed-Dose Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR and Dapagliflozin / Metformin XR…
- Trial name
- NCT03138356
- Testing
- 2.5 mg saxagliptin / 5 mg dapagliflozin / 850 mg metformin XR FDC tablet, 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR FDC tablet, 5 mg dapagliflozin / 850 mg metformin XR FDC
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Influenza, Vaccine Reaction
Effectiveness of Trivalent Influenza Vaccine (TIV) in Type 2 Diabetes Mellitus (T2DM) Patients With and Without Complications of Chronic Kidney Disease (CKD)
This study assesses the effectiveness of the seasonal flu vaccine in individuals with Type 2 Diabetes Mellitus (T2DM) with and without Chronic Kidney Disease (CKD), as well as in healthy individuals.
- Conditions
- Influenza, Vaccine Reaction, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- NCT06252051
- Testing
- Trivalent Influenza Vaccine
- Where
- Indonesia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Endometrioma, Thyroid
Comparison of Thyroid Volumes in Patients With and Without Endometrioma
The aim of our study is to evaluate whether there is a statistical difference between thyroid gland volume in patients with pathological diagnosis of endometriosis or endometrioma and in patients who underwent surgery for other…
- Trial name
- NCT05323539
- Testing
- Evaluating Thyroid Volumes by ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital
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