Clinical trials: Endocrine Disorder
Treatment Resistant Disorders
Adding L-carnitine in Clomiphene Resistant Polycystic Ovary Improves the Quality of Ovulation and the Pregnancy Outcome
Adding L-carnitine is more successful than clomiphene as a first line therapy for ovulation induction in women with clomiphene resistant PCOS
- Trial name
- NCT01665547
- Testing
- l-carnitine
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Diabetes (DM)
Feasibility Trial of a Sub-conjunctival Insert
The purpose of this single-centre, open label prospective study is to investigate a novel ocular mini insert (OMI) for detection of blood glucose levels in human subjects.
- Trial name
- OMI (NCT07105332)
- Testing
- OMI and Photometer
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- EyeSense GmbH
Cancer Diagnosis, LungCancer
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions.
- Conditions
- Cancer Diagnosis, LungCancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT06036563
- Where
- 8 sites in China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Diabetes
Personalised Medicine for Morbid Obesity
The prevalence of morbid obesity (BMI > 40 kg/m2) is increasing rapidly in the UK, but the investigators lack a coherent strategy for detailed assessment and treatment of the individuals affected, who are at high risk of…
- Trial name
- NCT01365416
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cardiovascular Disease
The Impact of Almond Nut Consumption on Markers of CVD & Metabolic Health
The purpose of this study is to investigate the cardio-metabolic health effects of consuming almond nuts in place of habitual (usual) snack products in adults at moderate risk of developing cardiovascular disease
- Trial name
- Almonds (NCT02907684)
- Testing
- Almonds, Muffins/Crackers
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- King's College London
Obesity, Diabetes Type 2
Pharmacogenetics of Response to GLP1R Agonists
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA.
- Trial name
- PORT (NCT05071898)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes
Protocol for the Evaluation of Dario™ BGMS Performance at Elevated Altitude
The purpose of this study is to assess the performance of the Dario Blood Glucose Monitor (BGMS), at elevated altitudes, by obtaining whole blood fingerstick samples from individuals and analyzing the blood on the Dario Blood…
- Trial name
- NCT02352298
- Testing
- Dario Blood Glucose Monitoring System, YSI Analyzer
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- LabStyle Innovations Ltd.
Type 1 Diabetes
The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes
The principal hypothesis of this study is that the micro and macro vasculature of young diabetes mellitus type 1 (DM1) patients is particularly susceptible to atherogenic factors which cause vascular dysfunction at multiple…
- Trial name
- NCT01337947
- Testing
- Definity microbubbles
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)
A 24 week study to compare the use of Metformin, birth control pills and a carefully planned intensive lifestyle program that includes weight loss and exercise.
- Trial name
- NCT00714233
- Testing
- Metformin, Oral Contraceptive Pills (Yasmin), Lifestyle Modification
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hereditary Breast and Ovarian Cancer
Identification and Referral of Women at Risk for Hereditary Breast/Ovarian Cancer
The purpose of this study is to identify the most effective means of follow-up for women who screen positive on B-RST (Breast Cancer Genetics Referral Screening Tool) applied in the standard clinical setting of mammography, to…
- Trial name
- NCT02786147
- Testing
- Breast Cancer Genetics Referral Screening Tool 3.0, Standard Handout, Physician Notification
- Where
- 2 sites in United States
- Volunteers
- 665 people, healthy volunteers welcome
- Sponsor
- Emory University
Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus)
Effect of Viscous Soluble Fibres on Body Weight
Abstract: Background: Obesity is a global pandemic affects all age groups and is independent risk factors for most chronic diseases. Dietary intervention is an essential component of obesity management.
- Conditions
- Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus), General Population
- Trial name
- NCT03257449
- Testing
- Viscous Fibre
- Where
- Canada
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Overactive Bladder, Insulin Resistance
Genomics and Epigenomics for New Insights in fEmale OAB (GENIE) Study
Millions of women suffer from overactive bladder, and the changes in bladder function affect their quality of life. The study team believes that it needs to be better understand why women get overactive bladder in the first place…
- Trial name
- GENIE (NCT03057158)
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Prediabetes
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction.
- Trial name
- Rhythm (NCT07820384)
- Testing
- Time restricted eating, Healthy Eating, Extended eating window
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Diabetes, Hyperglycemia Steroid-induced
Effect of Short Course of Glucocorticoid in Patients With Diabetes Mellitus(DM) Type 2
Participants will receive prednisone 40 mg for 3 days. 75 g oral glucose tolerance test (OGTT), insulin and C-peptide will be measured on day 1 (before prednisone) and day 3 (after prednisone).
- Trial name
- NCT03661684
- Testing
- Prednisone
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cook County Health
Healthy Volunteers, Overweight
First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes
The purpose of this study is to investigate how safe, and how well tolerated, the new study drug NNC0480-0389 is when it is given together with semaglutide.
- Conditions
- Healthy Volunteers, Overweight, Obesity, Diabetes Mellitus, Type 2
- Trial name
- NCT04259801
- Testing
- NNC0480-0389, Semaglutide
- Where
- Netherlands
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Hypoparathyroidism, Hyperparathyroidism
Corticosteroid Rhythms in Hypoparathyroid Patients
The investigators hypothesise that parathyroid hormon (PTH) depletion interferes with normal activity of the hypothalamus-pituitary-adrenal (HPA)-axis and the renin-angiotensin-aldosterone-system (RAAS), which in turn may impact…
- Trial name
- NCT02986607
- Testing
- parathyroid hormon 1-84
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Diabetes Mellitus, Type 2, PreDiabetes
Blood Markers of Early Pancreas Cancer
Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an…
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Pancreas Cyst, Chronic Pancreatitis
- Trial name
- NCT03568630
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Obesity, Type 2 Diabetes
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02159144
- Testing
- cold stress
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Short Stature, Growth Hormone Deficiency
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.
This project is designed to answer the question: Is there an acute IGFBP-3 response in normal children? Our specific hypothesis states that under the influence of growth hormone secretagogues, intact IGFBP-3 molecule will undergo…
- Trial name
- NCT00235599
- Testing
- IGFBP-3 Stimulation Test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Obesity; Endocrine
Study on the Mechanism of lcn2 in Obesity
Obesity is now becoming a worldwide serious problem. Obesity is associated with a spectrum of severe diseases, including diabetes, cardiovascular diseases, and cancers.
- Trial name
- NCT04573998
- Testing
- LSG
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shen Qu
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