Clinical trials: Endocrine Disorder
Diabetes Mellitus, Type 2, Coronary Artery Disease
Ticagrelor With and Without Aspirin in Patients With Diabetes Mellitus
Recent studies have shown that withdrawing aspirin and maintaining P2Y12 inhibitor monotherapy for up to 12 months post-PCI, after a brief period of DAPT, reduces bleeding without increasing ischemic harm.
- Trial name
- OPTIMUS-7 (NCT04484259)
- Testing
- Ticagrelor monotherapy, Ticagrelor plus aspirin, Clopidogrel with aspirin
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Florida
Orthostatic Hypotension, Diabetes
Insulin Therapy and Falls Due to Orthostatic Hypotension
In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and…
- Conditions
- Orthostatic Hypotension, Diabetes, Syncope
- Trial name
- NCT01914146
- Testing
- Insulin, No Insulin
- Where
- Canada
- Sponsor
- University of British Columbia
Ovarian Cancer
The Registry of Genetic Alterations of Taiwan Ovarian Cancer
Despite recent progress in chemotherapy and targeted therapy for ovarian cancer, the 5-year survival rate remains around 40% because of rapid development of treatment resistance and recurrence.
- Trial name
- NCT06127446
- Where
- 8 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Health Research Institutes, Taiwan
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Type 2 Diabetes Mellitus
Ghrelin and Beta Cell Function in Diabetes
Ghrelin is a hormone naturally produced in the stomach and the gut. The purpose of this research study is to determine the role of this gut hormone in the regulation of insulin secretion from the pancreas and glucose disposal…
- Trial name
- NCT02440061
- Testing
- Synthetic human AG, Arginine, 0.9% saline solution
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jenny Tong, MD, MPH
Obesity, Food Addiction
Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity
Morbid or severe obesity is a chronic pathology of multifactorial etiology that affects 4.3% of the French population. In these patients, eating disorders are frequent and must be managed as they are considered risk factors with…
- Trial name
- ADALOB (NCT04626570)
- Testing
- Cognitive and Behavioral Therapy
- Where
- 9 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Tours
Ovarian Cancer
Perifosine and Docetaxel in Patients With Relapsed Epithelial Ovarian Cancer
The goal of this clinical research study is to find out if a combination treatment of perifosine and docetaxel will help shrink or slow the growth of cancer cells in recurrent ovarian cancer.
- Trial name
- NCT00431054
- Testing
- Perifosine, Docetaxel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
T2D
BM-MNC and UCMSC for Type 2 Diabetes Mellitus Patients
The aim of this preliminary study is to evaluate the safety and efficacy of bone-marrow mononuclear cells (BM-MNCs) and umbilical-cord tissue-derived mesenchymal stem cells (UC-MSCs) administration in type 2 diabetes patients
- Trial name
- NCT04501341
- Testing
- Bone-marrow aspiration, Intra-pancreatic Catheterisation of BM-MNC, Intravenous Infusion of UC-MSC
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Indonesia
Diabetes, Hypoglycemia
Sitagliptin Versus Sulphonylurea in Type 2 Diabetes During Ramadan
This study will assess if Sitagliptin addition to metformin or glitazone is better than current sulphonylurea based treatments during Ramadan.
- Trial name
- NCT00766441
- Testing
- Sitagliptin, sulphonylurea
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Manchester
Peer Support and Chronic Disease, Obesity
Peer Support Dyads in Churches
The purpose of this study is to explore how working with a partner can influence participation in a church wellness program. There are many different types of church wellness programs.
- Conditions
- Peer Support and Chronic Disease, Obesity, Type II Diabetes, Cardiovascular Disease
- Trial name
- NCT03463941
- Testing
- Peer Support Dyad Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes Type II
Novel Biomarker for Development of T2D
The investigators wants to determine if 11β-HSD1 activity will be positively associated, and 5α-reductase activity negatively associated, with (a) degree of insulin resistance defined by the homeostatic model assessment of…
- Trial name
- NCT02326129
- Where
- 3 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes Mellitus
Glycemic Optimization On Discharge From the Emergency Room
Continuous glucose monitors can help people with diabetes avoid blood sugar levels that are either dangerously high or low. This study evaluates whether continuous glucose monitoring after discharge from the emergency room can…
- Trial name
- GOOD-ER (NCT05197829)
- Testing
- Continuous Glucose Monitoring, Care Coordination
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mark O'Connor
Type 2 Diabetes Mellitus
A Study of DS-8500a in Japanese Subjects With Type 2 Diabetes Mellitus Receiving Sitagliptin
The objectives of the study is to evaluate the efficacy and safety of DS-8500a compared with placebo in patients with type 2 diabetes mellitus (T2DM) receiving sitagliptin.
- Trial name
- NCT02685345
- Testing
- DS-8500a 25 mg, DS-8500a 75 mg
- Where
- Japan
- Volunteers
- 85 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Diabetes Mellitus, Type 2
Insulin Glargine in Type 2 Diabetes
The aim of this project is to confirm the efficacy and safety profile of Insulin glargine in daily practice and to improve the physicians' knowledge and experience concerning Insulin glargine
- Trial name
- NCT00268645
- Testing
- Insulin Glargine
- Where
- Turkey (Türkiye)
- Volunteers
- 534 people
- Sponsor
- Sanofi
Type 2 Diabetes, Obesity
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide.
- Conditions
- Type 2 Diabetes, Obesity, Semaglutide, GLP-1
- Trial name
- GLIMMER (NCT07272837)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Hyperglycemia
Hyperglycemia in a Coronary Intensive Care Unit
Newly diagnosed hyperglycemia (NDH) and stress hyperglycemia (SH) during acute illness is reported as a non-physiological condition in hospitals.
- Conditions
- Diabetes Mellitus, Hyperglycemia, Blood Glucose, Myocardial Ischemia
- Trial name
- NCT00984737
- Testing
- Insulin
- Where
- Turkey (Türkiye)
- Sponsor
- Baskent University
Albuminuria
Effects of Amlodipine/Benazepril on Albuminuria in Hypertensive Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus is usually associated with high blood pressure, which is a risk factor for kidney disease. Aggressive blood pressure reduction is an important strategy to protect the kidney and reduce urinary protein…
- Trial name
- NCT00136773
- Testing
- amlodipine/benazepril
- Volunteers
- 332 people
- Sponsor
- Novartis
Type 2 Diabetes
Characterization of Cardiovascular Risk Profile and Therapeutic Management in Patients With Type 2 Diabetes Mellitus in Italy
CardioMET is an observational, multicenter, real-life registry, intending to collect data on patients with Type 2 Diabetes Mellitus, attending internal medicine and cardiology outpatient clinics.
- Trial name
- CardioMET (NCT07375069)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Federico II University
Diabetes Mellitus, Type 2
Consultations in Adapted Physical Activity on Behaviours in Physical Exercise by Type 2 Diabetics
Assesment the impact of three individuals consultations in adapted physical activity by type 2 diabetics
- Trial name
- NCT00403741
- Testing
- motivational interviewing
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Pancreatic Cancer
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Hypothesis: Survival benefits could be found in SBRT Plus Pembrolizumab and Trametinib compared with SBRT plus gemcitabine.
- Trial name
- NCT02704156
- Testing
- Cyberknife plus Pembrolizumab and Trametinib, Cyberknife plus Gemcitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changhai Hospital
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