Clinical trials: Endocrine Disorders of Female Reproductive System
Polycystic Ovary Syndrome
PCOS Indirect and Intangible Economic Burden
The primary purpose of the PCOS Indirect and Intangible Economic Buren study is to estimate the economic costs of having PCOS in terms of quality of life and work productivity.
- Trial name
- PCOSCHALLENGE (NCT05903404)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- PCOS Challenge: The National Polycystic Ovary Syndrome Association
Ovarian Cancer, Healthy Volunteers
Safety and Biodistribution of Technetium Tc 99m EC20 in Normal Volunteers and Ovarian Cancer Patients
Open-label, single-center, single-treatment group, baseline-controlled (for safety) study of the safety and biodistribution of Technetium Tc 99m EC20 in four normal subjects and four subjects with known or suspected ovarian…
- Trial name
- NCT01689636
- Testing
- Tc 99m EC20
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Endocyte
Polycystic Ovary Syndrome, Diminished Ovarian Reserve
Clinical Trial of Anovulatory Infertility
This project aims to study the expression of clock genes and related proteins in follicular fluid and granulosa cells, depicting the periodic, amplitude, and phase changes of biological clock genes and related proteins in women…
- Conditions
- Polycystic Ovary Syndrome, Diminished Ovarian Reserve, Ovulation Disorder
- Trial name
- NCT06601452
- Testing
- a compound prescription of Chinese medicine
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nanjing University of Chinese Medicine
Polycystic Ovary Syndrome, Vitamin D Deficiency
Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome
This prospective cross-sectional case-control study aims to investigate the relationship between serum vitamin D levels, visceral adipose tissue (VAT) thickness, and metabolic parameters in adolescents diagnosed with polycystic…
- Conditions
- Polycystic Ovary Syndrome, Vitamin D Deficiency, Insulin Resistance
- Trial name
- NCT06970821
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Polycystic Ovary Syndrome, Metabolic Syndrome
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by elevated androgen levels due to ovarian overproduction.
- Trial name
- NCT06551285
- Testing
- Ovapro (Lifepro)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Indirect Inguinal Hernia, Undescended Testis
INVESTIGATION OF THE GENETIC ETIOLOGY OF HERNIA SAC DEVELOPMENT IN MALE CHILDREN WITH UNDESCENDED TESTIS AND INGUINAL HERNIA
The aim of the project is to elucidate the genetic etiology underlying the development of the processus vaginalis (PV) in male children with indirect inguinal hernia (IIH) and undescended testis (UT), through the investigation of…
- Trial name
- NCT07586332
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Trakya University
Polycystic Ovary Syndrome, Exposure to Endocrine Disruptors
History of Exposure to Endocrine Disruptors in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a common endocrine disorder that affects between 7% and 14% of women of childbearing age, leading to impaired fertility, clinical and biological hyperandrogenism.
- Trial name
- NCT04998448
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to investigate the use of ultra-high performance liquid chromatography-mass spectrometry for metabolomics and proteomics research in patients with Polycystic Ovary Syndrome (PCOS) and…
- Trial name
- NCT06256289
- Testing
- Canagliflozin 100mg Tab, Metformin Hydrochloride
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ping Li,MD
Polycystic Ovary Syndrome, Glucose Intolerance
Glucose Metabolism in Different PCOS Phenotypes
In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.
- Conditions
- Polycystic Ovary Syndrome, Glucose Intolerance, Liver Fat, Glucose Metabolism Disorders
- Trial name
- NCT03204461
- Testing
- Oral glucose tolerance test (OGTT), 1H-magnetic resonance spectroscopy
- Where
- Austria
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Hyperandrogenemia
Etiological Factors of Obesity-Associated Hyperandrogenemia in Peripubertal Girls
The purpose of this study is to learn if obese pre- and early pubertal girls with hyperandrogenemia (HA) are more insulin resistant (i.e., have lower insulin-stimulated glucose disposal) compared to obese peripubertal girls…
- Conditions
- Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
- Trial name
- CRM002 (NCT00928759)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
PCOS (Polycystic Ovary Syndrome)
Health-Related Quality of Life and Metabolic Outcomes in PCOS
The primary outcome of interest is change in PCOS health-related quality of life, while the secondary outcome of interest is change in adiposity, cardiometabolic, and inflammation biomarkers.
- Trial name
- NCT07571915
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
Ovarian Cancer, Endometrial Cancer
Advanced Methods for Cancer Detection by Vaginal Screening
This pilot study is the first step in the development of an new assay that may be further tested as a screening method for ovarian and endometrial cancers.
- Trial name
- ADVISE (NCT02622776)
- Testing
- Vaginal DNA Collection
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Anna Tinker
Polycystic Ovary Syndrome
Novel Subtypes of Polycystic Ovary Syndrome
To classify subtypes of Polycystic Ovary Syndrome (PCOS) using machine-learning algorithms, and compare the reproductive and metabolic characteristics and IVF outcomes across these identified subtypes.
- Trial name
- NCT06124391
- Testing
- Long-term follow-up
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Breast Neoplasms, Endometrial Neoplasms
Chemotherapy With Whole Body Hyperthermia to Treat Resistant Breast, Endometrial, Cervical and Ovarian Cancers
Thermal therapy (hyperthermia of heat) can increase the effect of chemotherapy treatments. By itself, thermal therapy can also kill cancer cells.
- Conditions
- Breast Neoplasms, Endometrial Neoplasms, Cervix Neoplasms, Ovarian Neoplasms
- Trial name
- NCT00178802
- Testing
- thermochemotherapy (with 5-fluorouracil/interferon-a/liposomal doxorubicin)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hyperandrogenism, Polycystic Ovary Syndrome
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CRM008 (NCT03068910)
- Testing
- Micronized progesterone, Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Awareness Of Gynecologists About Role Of Physical Therapy In Management Of Polycystic Ovarian Syndrome
This study aimed to measure the extent of knowledge of gynecologists about the role of physical therapy in the management of PCOS.
- Trial name
- NCT06543225
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Cairo University