Clinical trials: Endocrine System Disorder
Diabetes Mellitus, Type 1, Systolic Dysfunction
Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related…
- Conditions
- Diabetes Mellitus, Type 1, Systolic Dysfunction, Diastolic Dysfunction
- Trial name
- NCT06129448
- Testing
- transthoracic echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sirnak State Hospital
Obesity & Overweight, Type 2 Diabetes
A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers
Phase 1 Safety and Relative Bioavailability Study of DWRX5003 in Healthy Adults
- Trial name
- NCT07539415
- Testing
- DWRX5003, DWC202502, DWC202503
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
NAFLD (Nonalcoholic Fatty Liver Disease), Polycystic Ovarian Syndrome (PCOS)
PolyCystic Ovary Syndrome as Suggested Risk Group for Non-Alcoholic Fatty Liver Disease
To study the prevalence, non-invasive diagnostics and evolution of non-alcoholic-fatty-liver-disease (NAFLD) in patients with polycystic ovary syndrome (PCOS)
- Trial name
- P-CORIGA (NCT07146815)
- Testing
- FibroScan, MRI PDFF
- Where
- Belgium
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Menstrual Cycle Abnormal, Polycystic Ovary Syndrome
Quantum Menstrual Health Monitoring Study
The Quantum Menstrual Health Monitoring Study will measure four key reproductive hormones in the urine to characterize patterns that predict and confirm ovulation, referenced to serum hormones and the gold-standard of the…
- Conditions
- Menstrual Cycle Abnormal, Polycystic Ovary Syndrome, Athletes
- Trial name
- QMHMS (NCT05936840)
- Testing
- Mira Monitor tracking
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Quanovate Tech Inc.
Diabetes
Single Ascending Oral Doses of SY-008 in Healthy Subjects
This is a phase Ⅰ，single-center, randomized, double-blinded, placebo-controlled, single ascending dose trial of SY-008 in healthy subjects.
- Trial name
- NCT03462589
- Testing
- SY-008
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Insulin Resistance, Diabetes
Diabetes, Insulin Resistance and Body Composition
The goal of this retrospective study is to learn about the correlation between diabetes, insulin resistance and body compositions.
- Trial name
- NCT06724068
- Testing
- Diabetes，Insulin resistance，Control
- Where
- China
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- Xuan Song
PreDiabetes, Elevated Blood Sugar
Microlearning Application for Diabetes Prevention
The purpose of this study is to test the effectiveness of a mobile application diabetes prevention program delivered with microlearning and microcoaching.
- Trial name
- NCT05071820
- Testing
- Health U mobile application, National Diabetes Prevention Program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes, Exercise Physiology
Elevated FFA and Skeletal Muscle Lipid Content
There is increasing evidence that skeletal muscle lipid content (IntraMyoCellular Lipid, IMCL) markedly increases the risk of metabolic complications, including insulin resistance and cardiovascular events.
- Trial name
- NCT01906333
- Testing
- Exercise, Glucose, Fasted
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypogonadotropic Hypogonadism
Low Energy Availability and Pituitary Function (LEAP Study)
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
- Trial name
- LEAP (NCT05808647)
- Testing
- 5-day controlled metabolic dietary intake
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.
We investigated the effect of the administration of small doses of thyroxine to healthy humans and patients with type 2 diabetes on postprandial forearm muscle glucose uptake, insulin sensitivity indices, lipid metabolism, in…
- Trial name
- NCT02509858
- Testing
- thyroxine, A meal (730kcal, 50%carbohydrate, of which 38% was starch, 40% fat, and 10% protein)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Polycystic Ovary Syndrome, Metabolic Syndrome
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by elevated androgen levels due to ovarian overproduction.
- Trial name
- NCT06551285
- Testing
- Ovapro (Lifepro)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Histiocytosis, Langerhans-Cell
Cardiovascular Risk Factors and LCH in Adults
Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and hypopituitarism, conditions associated with increased risk of cardiovascular diseases.
- Trial name
- NCT00483925
- Where
- Greece
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Ovarian Cancer
Early Detection of Ovarian Cancer Using Plasma Cell-free DNA Fragmentomics (Retrospective Study)
The purpose of this study is to enable non-invasive early detection of ovarian cancer in high-risk populations through the establishment of a multimodal machine learning model using plasma cell-free DNA fragmentomics.
- Trial name
- NCT05693974
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Diabetes Mellitus, Type 2
A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CNTO 3649 in Healthy Adults and Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics of CNTO 3649 following a single dose in healthy adults and following multiple doses in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00882726
- Testing
- CNTO 3649 IV (Healthy participants), CNTO 3649 SC (Healthy participants), CNTO 3649 SC (Diabetic patients)
- Where
- 3 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Centocor, Inc.
Cardiovascular Disease, Diabetes Mellitus
Living With Statins - Interventional Exercise Study
Background. Statins are cholesterol lowering drugs that are prescribed to lower the risk of cardio-vascular diseases. The use of statins has increased markedly and it is now one of the most prescribed drugs in the world.
- Trial name
- LIFESTAT (NCT02796378)
- Testing
- Training+Simvastatin+Q10
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 1 Diabetes Mellitus
Investigation of Chronotropic Index, Exercise Capacity in Type 1 Diabetes Mellitus
To investigate whether diabetes affects lung function and exercise capacity and impairs autonomic nervous system.
- Trial name
- NCT04819815
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gazi University
Diabetes Mellitus, Gingival Recession, Generalized
Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial
The goal of this clinical trial is to evaluate local and systemic factors involved in palatal mucosal healing after Free Gingival Graft harvest in diabetic patients and to compare them with those in non-diabetic patients.
- Conditions
- Diabetes Mellitus, Gingival Recession, Generalized, Gingival Recession, Localized
- Trial name
- NCT07500935
- Testing
- Free gingival graft
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mauro Santamaria
Type 1 Diabetes Mellitus
Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas
BACKGROUND. Optimal glucose control can prevent/relent tissue damage in patients with type 1 diabetes mellitus (T1DM). Ongoing efforts aim at developing closed loop control (CLC) algorithms linking subcutaneous continuous glucose…
- Trial name
- NCT02003274
- Testing
- Clamp-Mixed Meal, IVGTT-Mixed Meal Arm
- Where
- 2 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes Mellitus, Type 2
Feasibility Study on the Impact of Economic Incentives to Improve the Management of Type 2 Diabetes Mellitus
This feasibility study aims to compare the implementation process of three different interventions that use economic incentives to promote lifestyle behavioral changes in patients with type 2 diabetes mellitus, and to identify…
- Trial name
- REDEEM-Pilot (NCT02891382)
- Testing
- Diabetes education, Goal setting, Companion Support
- Where
- Peru
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
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