Clinical trials: Endocrine System Disorder
Diabetes (DM)
Studies of Insulin and Glucagon Action in the Liver
This study examines how glucagon works to regulate glucose metabolism, based on new findings that suggest glucagon signaling in the liver has more than one role, and that these multiple roles can be opposing in nature.
- Trial name
- SIGNAL (NCT07300982)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Reproductive Effects, Pregnancy
Vitamin D and Pregnancy: Camden Study
Vitamin D is present in food either naturally or by fortification and included in nutritional supplements. It is also synthesized photochemically by the skin from ultraviolet B radiation.
- Trial name
- NCT02032459
- Where
- United States
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- Rowan University
Cancer, Hypogonadism
Prevalence of Hypogonadism in Male Cancer Patients
Cancer and its complications are common problems. In most cases, this condition has a profound impact on survival and quality of life (QoL).
- Trial name
- NCT00472940
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Puberty, Precocious
First Observatory of Precocious Puberty.
The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe.
- Trial name
- PAPPEL (NCT06263868)
- Where
- 23 sites in France
- Volunteers
- 3,360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Diabetes
N2-(1-carboxyethyl)-2'Deoxyguanosine (CEdG) a Potential Biomarker for Diabetes
The purpose of this study is to see if the CEdG assay can produce internally consistent results and initiate its validation as a biomarker for diabetes in humans.
- Trial name
- NCT02065310
- Testing
- N2-(1-carboxyethyl)-2'deoxyguanosine (CEdG)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pregnancy Complications, Diabetes Mellitus
Correlation of CGM Metrics With OGTT and Pregnancy Outcomes in Pregnant Women With or Without a High Risk for GDM
the aim of the study is to obtain CGM data concomitant with OGTT and to determine what CGM metrics obtained in pregnant women with and without a high risk of GDM correlate best with the diagnostic OGTT (obtained via the 2-step…
- Conditions
- Pregnancy Complications, Diabetes Mellitus, Hyperglycemic Disorder
- Trial name
- NCT05537480
- Testing
- Continuous glucose monitoring device
- Where
- Israel
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Type 2 Diabetes
Glimepiride Induced Insulin Secretion Will be Inhibited by Hypoglycemia
This study will look at two FDA approved medications that improve how the pancreas works in patients with Type 2 Diabetes. In order to understand how these medications work in patients with diabetes we must first measure the…
- Trial name
- NCT00608179
- Testing
- Glimepiride, glyburide, glucose clamp
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Type 2 Diabetes Mellitus
Safety Study of ISIS 325568 in Healthy Volunteers
The primary purpose of this trial is to assess the safety of ISIS 325568 when given at increasing single doses and to assess the safety of the same doses when given multiple times.
- Trial name
- NCT00519727
- Testing
- ISIS 325568
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Adrenal Insufficiency
A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects
This was a single centre, open label, randomised, two period, crossover study to evaluate the bioavailability of Chronocort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed healthy adult male…
- Trial name
- NCT03343327
- Testing
- Chronocort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Digestive Health, Quality of Life
Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024).
- Trial name
- NCT06946017
- Testing
- Fermented dairy protein with prebiotic fiber supplement
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Diabetes
Life Style Modifications Prevents Type 2 Diabetes in Asian Indians
Three year prospective randomised controlled trial in IGT subjects to study the effect of metformin and lifestyle modification in preventing the conversion to diabetes
- Trial name
- NCT00279240
- Testing
- Metformin
- Where
- India
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.V. Hospital for Diabetes
Pregnancy, Gestational Diabetes Mellitus
Investigation of Mechanisms for Transmission of Impaired Glucose Metabolism in Infants Exposed to Diabetes in Utero
This proposed study; Investigation of mechanisms for transmission of impaired glucose metabolism in infants exposed to diabetes in utero, will test the overarching hypothesis that impaired maternal substrate oxidation (metabolic…
- Trial name
- IMAGINE (NCT02926079)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Retinopathy, Diabetic, Diastolic Dysfunction
REWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes Mellitus
Retinopathy may be associated with diastolic dysfunction and/or coronary flow reserve in the heart, and albuminuria in diabetic patients.
- Conditions
- Retinopathy, Diabetic, Diastolic Dysfunction, Microalbuminuria
- Trial name
- NCT04025996
- Testing
- Cardiac Assessments and Eye Assessments
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Obesity, Diabetes
Crossover Trials Which Assessed Consumption of Slowly Digestible Carbohydrates for 21 Days on Gastric Emptying Rates
To gain a better understanding about the conditioning effect of consumption of slowly digestible carbohydrate on gastric emptying rate, respiratory quotient and metabolic flexibility, this study will focus on monitoring change in…
- Trial name
- INT (NCT05430061)
- Testing
- slowly digestible carbohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Purdue University
Elevated Triglycerides, Diabetes
Change of Fructose to Fat in South Asians
The purpose of this study is to determine whether hepatic de novo lipogenesis (DNL) in response to the ingestion of a mixture of glucose and fructose is greater in South Asians compared to controls (Caucasians).
- Conditions
- Elevated Triglycerides, Diabetes, Cardiovascular Disease, Dyslipidemia
- Trial name
- NCT01562782
- Testing
- Fructose + Glucose Beverage
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Overweight, Obesity
Effect of Dietary Habits on Metabolic Health
The goal of this application is to understand the connection between people's eating habits and the risk for developing diabetes, obesity, and cardiovascular disease.
- Conditions
- Overweight, Obesity, Prediabetes, Meals
- Trial name
- NCT02298790
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
This is an open-label study that will measure blood levels of different parts of a drug called GKS189075. People participating in this study will receive a single dose of 250mg GSK189075 by mouth.
- Conditions
- Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, Renal Insufficiency
- Trial name
- NCT00501462
- Testing
- GSK189075
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes, Food Insecurity
The Food for Health Study
The project, called Food for Health (F4H), will study a new Produce Prescription Program (PPP) designed for rural Native American older adults.
- Conditions
- Type 2 Diabetes, Food Insecurity, Rural Health
- Trial name
- F4H (NCT07254689)
- Testing
- Produce Prescription Program
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Montana
Polycystic Ovary Syndrome
AMH, Glucose Intolerance and Metabolic Syndrome in PCOS
Association between serum anti-Mullerian hormone (AMH) level and prevalence of glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS)
- Trial name
- NCT02676518
- Testing
- serum
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Glucose, Diabetes
Cmate Blood Glucose Analyzer: Clinical Comparison Study of Fasting Blood Glucose Levels in the Morning
As of February 2024, there are 529 million people worldwide living with diabetes. The number of diabetes patients continues to rise annually, and there is also a trend toward younger patients.
- Trial name
- NCT07088497
- Testing
- dietary control
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Revlis Biotech Company Limited
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