Clinical trials: Endocrine and Metabolic Diseases
Diabetes Mellitus, Diabetes Mellitus, Type 2
A Virtual Cardiometabolic Health Program for African Immigrants: The Afro-DPP Program
A pilot study titled "A Virtual Cardiometabolic Health Program for African Immigrants (The Afro-DPP Program) will be conducted to address the cardiometabolic of community-dwelling African immigrants who have multiple…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, PreDiabetes, Hypertension
- Trial name
- NCT05144737
- Testing
- The Diabetes Prevention Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes
This study is conducted to test the hypothesis that in type 2 diabetic adults with fatty liver who are resistant to metformin, treatment with liraglutide in combination with metformin will cause an absolute reduction in liver fat…
- Conditions
- Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Type 2 Diabetes
- Trial name
- LIRAINS (NCT01399645)
- Testing
- Liraglutide-metformin vs insulin-metformin
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Diabetes Mellitus: Type 1
A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus and to Compare One of Those Formulations (30Units) With an Injection of Insulin Lispro
28 subjects to be enrolled for a screening period, 3 dosing visits \& a follow-up visit. Visits 2 and 3 dosing of TI Inhalation Powder, cross over between two 15 U cartridges and one 30 U cartridge.
- Trial name
- NCT00662857
- Testing
- Technosphere® Insulin Inhalation Powder, Technosphere Insulin® Inhalation Powder, RAA Population
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Mannkind Corporation
Atherosclerosis, Type 2 Diabetes Mellitus
Effect of Sitagliptin on Progression of Coronary Intermediate Lesion
This study was to investigate the Effect of Sitagliptin, a dipeptidyl peptidase-4 inhibitor, on Progression of Coronary Intermediate Lesion.
- Trial name
- NCT02655757
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li Bo
Diabetes, Senile Dementia, Alzheimer Type
A Study of Mobile Medical Supportive Care Program for Family Caregivers With Dementia Combined With Diabetes
The purpose of this project is to evaluate the effectiveness of the clinical application of a mHealth supportive care program for family caregivers with dementia combined with diabetes based on the supportive care framework.
- Trial name
- NCT06785857
- Testing
- mHealth Supportive Care Program, Offline supportive care
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Diabetes Mellitus Type 2
A Study of a GLP-1 Analogue in Patients With Type 2 Diabetes Treated With Metformin.
This 6 arm study will evaluate the efficacy, safety, pharmacokinetics and pharmacodynamics of multiple doses and regimens of a GLP-1 analogue in patients with type 2 diabetes who are treated with a stable dose of metformin.
- Trial name
- NCT00423501
- Testing
- taspoglutide
- Where
- 49 sites in United States, Australia and 8 more
- Volunteers
- 306 people
- Sponsor
- Hoffmann-La Roche
Morality, Diabetes
Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight
The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The…
- Conditions
- Morality, Diabetes, Hypertension, Overweight
- Trial name
- NCT03281512
- Volunteers
- 14,383 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Type II Diabetes Mellitus
Retrospective Study of Patients With Type 2 Diabetes Mellitus on Dapagliflozin Therapy in Taiwan
Retrospective Study of Patients With Type 2 Diabetes Mellitus on Dapagliflozin Therapy in Taiwan.
- Trial name
- NCT03084965
- Where
- 8 sites in Taiwan
- Volunteers
- 1,987 people
- Sponsor
- AstraZeneca
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Obesity and Type 2 Diabetes
Stem Cell Isolation From Femoral Heads Post Total Hip Arthroplasty
Femoral heads will be collected at University Hospital (London, ON, Canada) from individuals with type-2 diabetes, obesity, and no T2D/no obesity controls.
- Trial name
- NCT06775600
- Testing
- Hip Replacement
- Volunteers
- 30 people
- Sponsor
- David Hess
Type 2 Diabetes
Efficacy and Safety of Saxagliptin VS. Glimepiride in Chinese T2DM Patients Controlled Inadequately With Metformin
This is a multi-centre, open-label, randomized, parallel trial to investigate the efficacy and safety profile of saxagliptin and glimepiride treatment in patients with type 2 diabetes inadequately controlled with metformin…
- Trial name
- SPECIFY (NCT02280486)
- Testing
- Saxagliptin, Glimepiride
- Where
- China
- Volunteers
- 388 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Congenital Adrenal Hyperplasia
Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia
This study is a randomized, double-blind, active-controlled, phase III study of Chronocort® compared with immediate-release hydrocortisone replacement therapy in participants aged 16 years and over with Congenital Adrenal…
- Trial name
- CONnECT (NCT05063994)
- Testing
- Chronocort, Cortef
- Where
- 21 sites in United States, France and 1 more
- Volunteers
- 55 people
- Sponsor
- Neurocrine UK Limited
Diabetes Mellitus, Type 2
Lowering Food Insecurity and Improving Diabetes With Financial Incentives
The overarching aim of this proposal is to test the efficacy of financial incentives in improving HbA1c, blood pressure, and quality of life in food insecure adults with poorly controlled type 2 diabetes.
- Trial name
- LIFT-FINANCE (NCT05352022)
- Testing
- Monthly Unconditional Financial Incentive, Weekly Food Purchasing Financial Incentive, Glycemic Control Financial Incentive
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- State University of New York at Buffalo
Diabetes, Healthy
Bioequivalence of Two Liraglutide Formulations in Healthy Volunteers
This trial is conducted in Europe. The aim of this trial is to test for bioequivalence of the phase 3a formulation of liraglutide (formulation 4) and the liraglutide formulation planned for phase 3b trials (final formulation 4).
- Trial name
- NCT01515553
- Testing
- liraglutide
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Novo Nordisk A/S
Prediabetes
Impact of Saccharin and Acesulfame-Potassium on Glycemia
The major purpose of this research project is to learn if consuming artificial sweeteners have any impact on glucose levels in adults at high risk for developing type 2 diabetes.
- Trial name
- NCT07506577
- Testing
- non-sugar sweetener - saccharin, non-sugar sweetener - acesulfame potassium, non-sugar sweetener - control
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Polytechnic Institute and State University
Type 2 Diabetes Mellitus
Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Combination Versus Insulin Glargine Alone on Top of Metformin in Type 2 Diabetic Patients
Primary Objective: The purpose of this study was to compare insulin glargine/ lixisenatide fixed ratio combination (FRC) versus insulin glargine on glycemic control over 24 weeks, as evaluated by glycosylated hemoglobin (HbA1c)…
- Trial name
- NCT01476475
- Testing
- Insulin glargine /lixisenatide Fixed Ratio Combination, Insulin glargine, Metformin (Background drug)
- Where
- 70 sites in United States, Chile and 11 more
- Volunteers
- 323 people
- Sponsor
- Sanofi
Female Infertility, Polycystic Ovary Syndrome
Evaluation of Clinical Outcomes and Costs of a Lifestyle Intervention in Obese Infertile Women
BACKGROUND: Obesity increases the risk of polycystic ovary syndrome (PCOS), characterized by anovulatory cycles, but it is also associated with reduced fertility even in ovulatory women.
- Conditions
- Female Infertility, Polycystic Ovary Syndrome, Obesity
- Trial name
- OF (NCT01483612)
- Testing
- Interdisciplinary lifestyle intervention
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Type 2
First Research Study of the Possible New Medicine NNC0113-2023 in Healthy Men.
The aim of this study is to assess how safe the study drug is and how well a participant tolerates it after a single oral (taken by mouth) dose.
- Trial name
- NCT03617081
- Testing
- NNC0113-2023
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus, Quality of Life (QOL)
Societal Burden Associated With Type 1 Diabetes in Canada
The purpose of this observational study is to estimate the burden of T1D on caregivers of patient with T1D in terms of work productivity, healthcare resource utilization and quality of life.
- Conditions
- Type 1 Diabetes Mellitus, Quality of Life (QOL), Work Productivity, Caregiver Subjective Burden
- Trial name
- T1D (NCT06786130)
- Testing
- observational study
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Type 2 Diabetes
Teneligliptin(MP-513) vs. Placebo in Patient With Metformin Monotherapy
The study design of this trial is double blind, parallel-group, randomized, Placebo controlled study.
- Trial name
- T2DM (NCT01805830)
- Testing
- MP513
- Where
- South Korea
- Volunteers
- 189 people
- Sponsor
- Handok Inc.
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