Clinical trials: Endocrine and Metabolic Diseases
Type 2 Diabetes Mellitus
Simplified Onboarding in Adults With Type 2 Diabetes
This is an outpatient study testing different starting doses of insulin in participants with type 2 diabetes. Participants will manage their diabetes using the Omnipod M System.
- Trial name
- SIMPLEUSE (NCT07070830)
- Testing
- Active Comparator: Omnipod M System with lower starting dose, Active Comparator: Omnipod M System with higher starting dose
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Insulet Corporation
Lipodystrophy, Familial Partial
Familial Partial Lipodystrophy Study
Studying patients with rare adipose tissue disorders may help the investigators to better understand the pathophysiology of diabetes and dyslipidemia in relation to adiposity, and thus have an enormous impact on public health.
- Trial name
- FPL (NCT02858830)
- Testing
- High fat mixed meal
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Open-label Investigation of the Safety and Efficacy of DIABECELL in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to establish the efficacy and safety of xenotransplantation of DIABECELL [immunoprotected (alginate-encapsulated) porcine islets] in patients with established type 1 diabetes mellitus
- Trial name
- NCT01736228
- Testing
- DIABECELL
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Living Cell Technologies
Diabetes Mellitus, Type 1
Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes
This study is evaluate the superior efficacy of a Continuous Glucose Monitor (CGM)-based advisory system in Type 1 Diabetes Mellitus (T1DM), as compared to Sensor Augmented Mode (SAM) therapy, and with characterizing the impact…
- Trial name
- DSS-2 (NCT04443153)
- Testing
- Personalized Feedback, Decision Support System, Sensor Augmented Mode
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Text Message for Adolescents With Poorly Controlled Type 1 Diabetes
The purpose of this study is to assess HbA1c reduction after supportive care by SMS among adolescents with poorly controlled type 1 diabetes.
- Trial name
- DIABETO-SMS (NCT02230137)
- Testing
- Text message arm
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Type 2 Diabetes
The Effect of Exercise on Hepatic Glucose Metabolism
It is known that obesity and/or physical inactivity greatly increase a person's risk of developing heart disease and other serious health problems.
- Trial name
- NCT01783275
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Diabetes, Wounds
Plerixafor in Diabetic Wound Healing
Chronic non-healing wounds represent a major source of morbidity, disability, and mortality in diabetic patients. Diabetes is the leading cause of non-traumatic limb amputations worldwide.
- Conditions
- Diabetes, Wounds, Critical Limb Ischemia
- Trial name
- MOZOBL07740 (NCT02790957)
- Testing
- Plerixafor
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Gian Paolo Fadini
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus
Exubera Large Simple Trial To Evaluate Long-Term Pulmonary And Cardiovascular Safety
The purpose of this study is to evaluate the long-term pulmonary and cardiovascular safety of Exubera in routine clinical practice.
- Trial name
- VOLUME (NCT00359801)
- Testing
- Randomization to Exubera (insulin human [rDNA origin] inhalation powder) or Usual Diabetes Care
- Where
- 197 sites in United States, Germany and 3 more
- Volunteers
- 1,976 people
- Sponsor
- Pfizer
Type 1 Diabetes, Hypoglycemia
Insulin Management for Exercise in Patients With Type 1 Diabetes
The purpose of this study is to compare the time spent in glucose target range (4.0-10.0 mmol/L) during exercise and in recovery using three different basal insulin management strategies for prolonged aerobic exercise: A) pump…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Physical Activity
- Trial name
- NCT03130101
- Testing
- Change in their basal insulin rate
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- York University
Diabetes Mellitus, Type 2
Acute Effects of Aerobic Exercise on Flow Mediated Slowing and Flow Mediated Dilation in Adults With and Without Type 2 Diabetes
The endothelium is a protective lining of cells inside blood vessels. It keeps blood vessels working smoothly by controlling how wide or narrow your blood vessels are and protecting them from damage.
- Trial name
- ARM WRESTLING (NCT06684912)
- Testing
- High-intensity interval exercise, Moderate continuous exercise
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Type 2 Diabetes
Myocardial Perfusion in Type 2 Diabetes
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
- Trial name
- NCT01043965
- Testing
- Metformin
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type 1 Diabetes, Obesity
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
The main purpose of this study is to find out how well and how safely tirzepatide works long-term in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 20 months.
- Conditions
- Type 1 Diabetes, Obesity, Overweight
- Trial name
- SURPASS-T1D-2 (NCT06962280)
- Testing
- Tirzepatide
- Where
- 79 sites in United States, Argentina and 8 more
- Volunteers
- 465 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Chronic Disease
Patient Activation Through Community Empowerment/Engagement for Diabetes Management (PACE-D)
The study is a non-randomised controlled trial involving an intervention group and a control group. It aims to evaluate the effects of a patient engagement and empowerment model of collaborative care support planning on clinical…
- Conditions
- Diabetes Mellitus, Chronic Disease, Patient Care Planning, Patient Participation
- Trial name
- PACE-D (NCT04288362)
- Testing
- Intervention Group, Control Group
- Where
- Singapore
- Volunteers
- 1,620 people
- Sponsor
- National University Health System, Singapore
Healthy
A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
The purpose of this study is to assess the bioequivalence (similarity of the drug amount in blood among the formulations) of the fixed dose combination (two components combined in one tablet) of canagliflozin and metformin…
- Trial name
- NCT02077803
- Testing
- Canagliflozin, 100 mg, Metformin XR, 500 mg, CANA/MET XR FDC, Formulation 1, 50 mg/1000 mg
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Prediabetes (Impaired Fasting Glucose and/or Impaired Glucose Tolerance)
Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes
The purpose of this study is to determine whether Rubus occidentalis extract could improve fasting or postprandial serum glucose levels, and related metabolic markers among patients with prediabetes (impaired fasting glucose…
- Trial name
- NCT01964703
- Testing
- Rubus occidentalis extract
- Volunteers
- 29 people
- Sponsor
- Korea University Anam Hospital
Reflexology, Type 2 Diabetes
Effect of Reflexology on Diabetic Foot and Glycemic Control in Elderly Diabetic Individuals
Background: Glycemic control can be difficult in the elderly with diabetes.Diabetic foot problems characterized by vascular and neuropathy are serious complications.
- Conditions
- Reflexology, Type 2 Diabetes, Older People
- Trial name
- NCT04416503
- Testing
- Foot reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Abant Izzet Baysal University
Diabetes Mellitus
The Skills, Confidence & Preparedness Index (SCPI)
The LMC Skills, Confidence and Preparedness Index (SCPI) is a tool that was developed by diabetes specialists to individualize the education/support that a healthcare provider delivers to patients with diabetes.
- Trial name
- SCPI (NCT03863561)
- Testing
- Diabetes self-management education (DSME) program
- Where
- 7 sites in Canada
- Volunteers
- 486 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Type 2 Diabetes Mellitus, Obesity
Inulin,SCFA Production and Metabolic Response
In this placebo controlled, double-blind, randomized crossover study the investigators will investigate in overweight/obese healthy male volunteers whether inulin administration will increase intestinal SCFA production, thereby…
- Trial name
- NCT02009670
- Testing
- 13C inulin
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Pre Diabetes
Development and Validation of DM and Pre-DM Risk Prediction Model
Many DM and pre-DM remain undiagnosed. The aim is to develop and validate a risk prediction function to detect DM and pre-DM in Chinese adults aged 18-84 in primary care (PC). The objectives are to: 1.
- Trial name
- NCT04881383
- Testing
- OGTT and HbA1c
- Where
- Hong Kong
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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