Clinical trials: Endocrine and Metabolic Diseases
Diabetes
Effects of Moringa Oleifera on hsCRP and Hgba1c Level of Patients in Ospital ng Maynila Medical Center Diabetic Clinic
Current evidence supports a central role of inflammation in the pathogenesis of atherosclerosis and diabetes [57-60]. Diabetes Mellitus type 2 is an inflammatory atherothrombotic condition associated with high prevalence of…
- Trial name
- NCT02308683
- Testing
- Moringa oleifera
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ospital ng Maynila Medical Center
Diabetes Mellitus, Type 2
A Phase II Study to Evaluate the Effects of Oral ONO-5129 in Type 2 Diabetes Mellitus
The objectives of this study are to characterize the pharmacodynamic profile, safety and tolerability of ONO-5129 in patients with Type 2 Diabetes mellitus
- Trial name
- NCT00212641
- Testing
- ONO-5129
- Where
- 67 sites in United States
- Volunteers
- 105 people
- Sponsor
- Ono Pharma USA Inc
Diabetes Mellitus
SEGUDIAB Study: Evaluation of Safety in the Diabetic Patients
The safety in the diabetic patient refer so much to the accuracy of the treatment and to the handling of the diabetic in security topics.
- Trial name
- SEGUDIAB (NCT01087541)
- Testing
- Educational program 6-hour standardized
- Where
- Spain
- Volunteers
- 6,830 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Diabetes
Evaluation of the Effects of Heating or Massaging or Vibrating at the Vicinity of the Insulin Delivery Site
The aim of this study is to test the pharmacodynamics of insulin analogs and their dependence on external and physiological alterations.
- Trial name
- NCT00767741
- Testing
- with heat and massage
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Insuline Medical Ltd.
Diabetes Mellitus, Type 2
Extension to a Study to Assess the Efficacy and Safety of Three Doses of Vildagliptin in Patients With Type 2 Diabetes
This is a 28-week extension to a study of the safety and effectiveness of three doses of vildagliptin, an unapproved drug, compared to placebo in lowering overall blood glucose levels in people with type 2 diabetes who have not…
- Trial name
- NCT00138541
- Testing
- vildagliptin
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Novartis
Gestational Diabetes Mellitus With Baby Delivered
The MoMMii Study. Diabetes Prevention Intervention on Families With Past Gestational Diabetes
Women with gestational diabetes (GDM) have increased risk of developing type 2 diabetes; their children show more insulin resistance and diabetes compared to offspring of mother without diabetes in pregnancy.
- Trial name
- MoMMii (NCT02343354)
- Testing
- Nutrition/physical activity intervention
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Type 2
Efficacy and Safety of Vildagliptin Versus Placebo in Patients With Type 2 Diabetes
This mechanistic study is designed to investigate the effect of vildagliptin on the sensitivity of the a-cell to glucose under hypoglycemic conditions in patients with type 2 diabetes (T2DM).
- Trial name
- NCT00390520
- Testing
- Vildagliptin
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- Novartis
Type 1 Diabetes Mellitus
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
The biggest challenges for glycemic control during the day time involve meals and exercise variations, which are impacted by age, fitness level, duration, intensity and history of exercise.
- Trial name
- NCT02604524
- Testing
- Closed-Loop Control, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Daniel Chernavvsky, MD, CRC
Type 2 Diabetes
Efficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)
This long term, placebo-controlled trial is intended to assess the efficacy and safety of exenatide, dosed twice a day, in Japanese patients with Type 2 Diabetes who are treated with oral antidiabetic(s) but not well controlled.
- Trial name
- NCT00577824
- Testing
- exenatide
- Where
- 12 sites in Japan
- Volunteers
- 181 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Long-term Daily Use of Trazenta® Tablets in Patients With Type 2 Diabetes Mellitus
Study to investigate the safety and efficacy of long-term daily use of Trazenta® Tablets as monotherapy in patients with type 2 diabetes mellitus and to assess baseline characteristics of patients with type 2 diabetes mellitus…
- Trial name
- NCT01650259
- Testing
- OAD, Trazenta
- Where
- Japan
- Volunteers
- 4,876 people
- Sponsor
- Boehringer Ingelheim
Gastric Cancer, Type 2 Diabetes
Roux-en-Y Versus Billroth II Reconstruction After Subtotal Gastrectomy in Gastric Cancer Comorbid With Type II Diabetes
Gastric bypass improves glycemic levels in type 2 diabetes. However, the efficacy may be varied by different gastric-small intestine reconstruction used in the procedure.
- Trial name
- NCT01528059
- Testing
- Stomach-small intestine reconstruction
- Where
- China
- Volunteers
- 110 people
- Sponsor
- feng Zheng
Type 1 Diabetes Mellitus
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus on Basal Plus Mealtime Insulin
Primary Objective: To compare the glucose control during treatment with a new formulation of insulin glargine and Lantus in adult participants with type 1 diabetes mellitus Secondary Objectives: To compare a new formulation of…
- Trial name
- NCT01658579
- Testing
- HOE901-U300 (new formulation of insulin glargine), Lantus (insulin glargine)
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Sanofi
Diabetes
Clinical Characteristics and Disease Burden of Diabetic Patients Based on Tianjin Regional Database
The study aims to investigate the clinical characteristics, treatment, and economic burden of disease of Chinese diabetic/non-diabetic patients with/without established cardiovascular disease (CVD), chronic kidney disease (CKD)…
- Trial name
- NCT04903496
- Where
- China
- Volunteers
- 1,233,162 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
Acute Studies on the Glycemic Index After Intake of Different Sorts of Barley in Subjects With Type 2 Diabetes
In a series of double-blinded randomized cross-over acute studies, the investigators want to study the effects of different types of barley on the glycemic index (GI) in subjects with type 2 diabetes.
- Trial name
- NCT04646746
- Testing
- 100% wheat, 50% nude barley and 50% wheat, 75% nude barley and 25% wheat
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Thyroid, PD-1
Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors
The purpose of this research study is to see if the amount of vitamin D in ones blood makes it more or less likely to develop thyroid gland toxicity when being treated with immunotherapy that blocks the activity of proteins…
- Conditions
- Thyroid, PD-1, Cancer
- Trial name
- NCT04615988
- Testing
- blood draw and questionnaire completion, questionnaire completion, blood collection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Insulin Resistance
Identifying Risk for Diabetes and Heart Disease in Women
Background: Rates of diabetes and heart disease in women are increasing. Early recognition of risk could help women live longer and healthier lives.
- Conditions
- Obesity, Insulin Resistance, Triglycerides, Diabetes
- Trial name
- NCT01809288
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 2
Efficacy and Safety of Vildagliptin Compared to Gliclazide in Drug Naive Patients With Type 2 Diabetes
This study is not being conducted in the United States. The purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to gliclazide in lowering overall blood glucose levels in…
- Trial name
- NCT00102388
- Testing
- vildagliptin, Gliclazide
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,092 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes, Postprandial Hypotension
Acarbose, Postprandial Hypotension and Type 2 Diabetes
Postprandial hypotension carries a risk of significant morbidity and morbidity including syncope, falls, dizziness, fatigue, stroke and myocardial infarction.
- Trial name
- NCT02043886
- Testing
- Acarbose
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Type 2 Diabetes Mellitus
Preservation of Beta-cell Function in Type 2 Diabetes Mellitus
The study evaluates the rate beta-cell function decline in newly diagnosed type 2 diabetic patients on two different treatment regimens: insulin and metformin versus glyburide, metformin and pioglitazone.
- Trial name
- NCT00232583
- Testing
- Metformin, Insulin, Metfomin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus
Phase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus
Study D5553C00002 is a multicenter, randomized, double-blind, placebo-controlled, parallel group, Phase 3 study to compare the safety and efficacy of exenatide once weekly (EQW) added to titrated basal insulin glargine with or…
- Trial name
- NCT02229383
- Testing
- Exenatide
- Where
- 123 sites in United States, Hungary and 4 more
- Volunteers
- 464 people
- Sponsor
- AstraZeneca
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