Clinical trials: Endodontic Diseases
Apical Periodontitis
Intraoral Cryotherapy on Cytokine Levels and Postoperative Endodontic Pain
The aim of this study is to evaluate the effects of intraoral cryotherapy on the inflammatory cytokine levels during root canal treatment and postoperative pain intensity and incidence.
- Trial name
- NCT05017064
- Testing
- Cryotherapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Pain, Postoperative, Pain
Effect of Different Obturation Techniques on Postoperative Pain
This study evaluated the postoperative pain after the endodontic treatment by using three different obturation techniques. ( Cold lateral condensation (CLC), thermoplasticized solid-core carrier method (GuttaCore) and cold…
- Conditions
- Pain, Postoperative, Pain, Endodontic Inflammation
- Trial name
- NCT04228913
- Testing
- Root Canal Obturation Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Apical Periodontitis
The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study
The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic…
- Trial name
- NCT06764004
- Testing
- Stem Cell Product, Bleeding and clots
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Gagging, Satisfaction, Patient
Controlling Gag Reflex During Endodontic Diagnostic Radiography
Intraoral radiography plays a vital role in endodontic diagnosis and treatment planning. However, many patients experience discomfort during periapical radiographic procedures due to factors such as a pronounced gag reflex and…
- Conditions
- Gagging, Satisfaction, Patient, Endodontic Disease, Anxiety
- Trial name
- NCT07236138
- Testing
- Periapical radiograph will be taken without VR, Periapical radiograph will be taken with VR
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qassim University
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontitis
Background Root canal therapy is the primary treatment of choice for necrotic mature teeth with periapical lesions (PRLs), which does not restore the tooth's vitality.
- Trial name
- NCT06179433
- Testing
- Root canal treatment, Regenerative endodontic procedure
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Post-operative Pain, Retreatment
Evaluation of Postoperative Pain After Single Visit Retreatment of Symptomatic and Asymptomatic Teeth
Introduction: The aim of this study comparing the post operative pain after the retreatment of asymptomatic and symptomatic teeth that during single visit treatment with rotary and reciprocal nickel titanium files.
- Conditions
- Post-operative Pain, Retreatment, Symptomatic Periapical Periodontitis, Endodontic Disease
- Trial name
- Endodontics (NCT06357481)
- Testing
- Endodontic Retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periapical Periodontitis, Tooth Diseases
Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
This study evaluates the clinical effect of regenerative endodontic procedure using PRF in immature permanent teeth with apical periodontitis.
- Conditions
- Periapical Periodontitis, Tooth Diseases, Stomatognathic Diseases
- Trial name
- NCT02801552
- Testing
- PRF
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Periapical Periodontitis
Hyaluronic Acid in Endodontic Microsurgery
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first…
- Trial name
- NCT07501585
- Testing
- Hyaluronic Acid, Endodontic microsurgery
- Where
- Russia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Endodontic Disease, Root Canal Infection
Comparison of Antibacterial Efficacy of Three Final Irrigants
This study was conducted to determine the antibacterial affect of three different solutions used as final irrigant during endodontic therapy.
- Trial name
- NCT03853200
- Testing
- QMix Root Canal Irrigant, 17%EDTA+2%Chlorhexidine, EDTA
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Retreatment, Endodontic Diseases
THE EFFECT OF FILLING MATERIAL AND PLACEMENT TECHNIQUE ON POSTOPERATIVE PAIN IN NON-SURGICAL ENDODONTIC RETREATMENT: A RANDOMIZED CLINICAL TRIAL
Postoperative pain is a common concern following root canal retreatment. The type of root canal filling material and the technique used to place it may influence pain experienced after treatment.
- Trial name
- NCT07908394
- Testing
- BioMTA+, Well-Root PT
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Teeth, Endodontically-Treated
Safety and Efficacy of Using the Endodontic Self Adjusting File - SAF for Root Canal Treatment
The study's primary goal is to assess the safety of the SAF (Self Adjusting File) device for root canal treatments. The study's secondary goal is to evaluate the effectiveness of the SAF device for root canal treatments
- Trial name
- NCT00497042
- Testing
- Self Adjusting File
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ReDent Nova
Endodontic Disease, Endodontic Inflammation
Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment
Purpose: To evaluate anesthetic efficacy and overall patient experience with use of Kovanaze tetracaine/oxymetazoline nasal spray for root canal treatment of vital premolar and anterior teeth needing root canal treatment.
- Conditions
- Endodontic Disease, Endodontic Inflammation, Local Anesthesia, Dental Anesthesia
- Trial name
- NCT03502135
- Testing
- Tetracaine HCl and oxymetazoline HCl nasal spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Root Canal Treatment
Post-Endodontic Pain According to Menstrual Cycle Phases
This study aimed to evaluate whether the phase of the menstrual cycle affects pain after root canal treatment. A total of 99 patients (72 females and 27 males) who needed root canal treatment in lower molar teeth were included.
- Trial name
- PEP-MC (NCT07291518)
- Testing
- root canal treathment
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ahter Sanal Cikman