Clinical trials: Endometriosis, Rectum
Endometriosis, Endometriosis Ovary
Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis
Background: Endometriosis is a chronic gynecological disease with the growth of endometrial tissue outside the endometrium. In all its properties, this tissue is similar to the mucous membrane of the uterus.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Externa, Endometriosis, Rectum
- Trial name
- ELTA (NCT03481842)
- Testing
- Linifanib, BIBW2992, Axitinib
- Where
- Switzerland
- Sponsor
- BioGene Pharmaceutical Ltd.
Endometriosis, Endometriosis of Colon
Intraoperative vs Transvaginal Ultrasound in Rectosigmoid Endometriosis
Deep infiltrating endometriosis (DIE) of the rectum and rectosigmoid colon represents one of the most severe forms of endometriosis and often requires surgical management when symptomatic and unresponsive to medical therapy.
- Conditions
- Endometriosis, Endometriosis of Colon, Endometriosis; Bowel, Endometriosis, Rectum
- Trial name
- INTREND (NCT07517055)
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis, Rectum
Surgery for Lower Rectum Deep Endometriosis (Segmental/Disc) - Prospective Comparison of Digestive Symptoms and Pain
Several studies show a significant drop in pain scores, improved fertility outcomes and amelioration of impaired sexual functioning in women following surgical resection of colorectal endometriosis.
- Trial name
- NCT04398641
- Testing
- Evaluation of pre- and postoperative gastrointestinal functional outcomes
- Where
- 2 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Univ.-Doz. Dr.med.univ. Gernot Hudelist, MSc.
ULTRASONOGRAPHY, Endometriosis, Rectum
The Identification of Optimal Ultrasonografic Tecniques for Determining the Location , Size and the Surgical Methods of Intestinal Endometriotric Nodules
The identification of optimal ultrasonografic tecniques for determining the location , size and the surgical methods of intestinal endometriotric nodules
- Trial name
- Sonography (NCT04891003)
- Testing
- Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Endometriosis, Deep Endometriosis
The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma
The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma.
- Conditions
- Endometriosis, Deep Endometriosis, Bowel Endometriosis, Colorectal Carcinoma
- Trial name
- NCT07386431
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Endometriosis, Endometriosis-related Pain
Intraoperative Sono-assessment In Deep Endometriosis
Deep infiltrating endometriosis (DIE) involving the bowel, particularly the rectosigmoid region, is associated with significant gastrointestinal symptoms and impaired quality of life.
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome, Endometriosis, Rectum
- Trial name
- INSIDE (NCT07517081)
- Volunteers
- 57 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis, Rectum
Endoscopic Rectal UltraSound With Elastosonography and Contrast in Deep Pelvic Endometriosis With Bowel Involvement
The aim of the study will be to determine the diagnostic and prognostic value of elastosonography and the use of the contrast agent (Sonovue®) in the endoscopic ultrasound exploration of deep pelvic endometriosis.
- Trial name
- NCT03138954
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Société Française d'Endoscopie Digestive
Endometriosis, Rectum
Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Rectal Endometriosis
Rectal endometriosis (RE) induces lesions associated with painful symptoms that can alter quality of life. High Intensity Focused Ultrasound (HIFU) is a non-invasive ablative procedure using a high-intensity ultrasound probe to…
- Trial name
- ENDO-HIFU-R1 (NCT04494568)
- Testing
- HIFU treatment
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- EDAP TMS S.A.
Endometriosis Rectum
Association Between Ultrasound Morphology of Intestinal Endometriosis Nodules and Symptom Severity
Association between the ultrasound appearance of deep bowel endometriosis and the frequency of pain
- Trial name
- NCT06720688
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometriosis, Endometriosis Ovary
EHP-5 in Preoperative Assessment in Women With Endometriosis
There is no validated tool in quality-of-life assessment of women with endometriosis in Croatia. First aim is to validate Endometriosis Health Profile-5 (EHP-5) before implementing this questionnaire in clinical practice.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis-related Pain, Quality of Life
- Trial name
- EHP-5CRO (NCT04491305)
- Testing
- Surgically treated women with endometriosis and confirmed diagnosis
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University of Zagreb
Endometriosis, Rectum, Endometriosis of Colon
Bidimensional Rectal-water Contrast-transvaginal Ultrasonography (2D-RWC-TVS) Versus 3D-RWC-TVS in the Diagnosis of Rectosigmoid Endometriosis
An accurate diagnosis of the presence, location and extent of the rectosigmoid endometriosis is of paramount importance for the clinicians in order to inform the patients on the potential surgical or medical treatments.
- Trial name
- 3Dvs2D-RWC-TVS (NCT04339946)
- Testing
- Three-dimensional rectal water contrast transvaginal ultrasonography (3D-RWC-TVS), Two-dimensional rectal water contrast transvaginal ultrasonography (2D-RWC-TVS)
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Ospedale Policlinico San Martino
Endometriosis Related Pain, Quality of Life
Bowel ENDOmetriosis; Evaluation of Diagnostics and Quality of Life
Endometriosis on the bowel is a benign condition that can cause major complaints and severely affect the quality of life of women of fertile age.
- Conditions
- Endometriosis Related Pain, Quality of Life, Pain, Chronic, Bowel Dysfunction
- Trial name
- ENDO (NCT03779256)
- Testing
- 2D transvaginal ultrasound
- Where
- 3 sites in Australia, Austria and 1 more
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital
Endometriosis, Rectum
Bowel Preparation Before 3D Rectal Water Contrast Transvaginal Ultrasonography for Rectosigmoid Endometriosis
Three-dimensional (3D) rendering may be employed during transvaginal rectal water-contrast transvaginal ultrasonography (RWC-TVS) for detecting the presence and describe the characteristics of rectosigmoid endometriosis.
- Trial name
- NCT04406155
- Testing
- 3D-RWC-TVS with bowel preparation, 3D-RWC-TVS without bowel preparation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
Endometriosis, Rectum, Bowel Endometriosis
Indocyanine Green and Rectosigmoid Endometriosis
Indocyanine green is a fluorescent dye used for the intraoperative evaluation of tissue perfusion. The aim of this study is to evaluate a possible correlation between rectosigmoid vascularization and surgical and clinical data…
- Trial name
- vincendo (NCT03532074)
- Testing
- assessment of bowel symptoms before surgery, assessment of rectosigmoid during laparoscopy, follow up and assessment of bowel symptoms after surgery
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometriosis
Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
Deep invasive endometriosis (DIE) includes lesions of the rectosigmoid. Theses lesions are associated with painful symptoms that can alter quality of life.
- Trial name
- NCT03613298
- Testing
- HIFU (Focal One®)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- EDAP TMS S.A.
Endometriosis, Rectum
Persistence Disease After Laparoscopic Shaving of Rectal Endometriosis
When performing shaving of a rectal endometriotic nodule, the surgeon can use the macroscopic appearance of the nodule and the tactile feedback provided by the laparoscopic instruments to decide the area of the bowel that needs…
- Trial name
- ENDO-SHAVING (NCT04411004)
- Testing
- Transvaginal ultrasound, 5-point Likert scale
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Policlinico San Martino
Deep Endometriosis, Surgery
Surgical TReatment of Women With Deep ENDometriosis
TrEnd trial is aimed to collect data from consecutive patients undergoing segmental sigmoid colon/rectal resection for deep endometriosis.
- Trial name
- TrEnd (NCT06386276)
- Testing
- Colorectal bowel resection
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Casa di Cura Privata 'Malzoni - Villa dei Platani' S.P.A.
Endometriosis, Endometriosis, Rectum
Patient Reported Outcomes After Surgery for Rectal Endometriosis
To describe the difference in patient reported outcomes after conservative treatment in comparison to radical rectal surgery in patients with deep endometriosis infiltrating the rectum (up to 15cm from the anus with at least…
- Conditions
- Endometriosis, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis; Bowel
- Trial name
- PROCURE (NCT04204707)
- Testing
- PROMS
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 294 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis, Rectum
Functional Outcomes of Surgical Management of Deep Endometriosis Infiltrating the Rectum
The purpose of this study is to determine whether performing colorectal resection in deep endometriosis infiltrating the rectum is responsible for a higher rate of postoperative digestive and urinary dysfunction when compared to…
- Trial name
- ENDORE (NCT01291576)
- Testing
- Rectal/colorectal segmental resection, Rectal nodule excision
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Endometriosis, Sigmoid, Endometriosis, Rectum
Three-dimensional (3D) Rectal Water Contrast Transvaginal Ultrasonography Versus Computed Colonography in the Diagnosis of Rectosigmoid Endometriosis
Rectosigmoid involvement by endometriosis causes intestinal symptoms such as constipation, diarrhea, and dyschezia. A non-invasive diagnosis of bowel endometriosis is relevant to provide the patients information on the potential…
- Trial name
- NCT04295343
- Testing
- Three-dimensional (3D) rectal water contrast transvaginal ultrasonography, Computed colonography
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino