Clinical trials: Endometriosis; Peritoneum
Endometriosis; Peritoneum, Endometriosis
Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue
This study aims to evaluating inflammatory and apoptotic activity in rat's endometriosis lesion treated by Propolis compared to Dienogest
- Trial name
- NCT04374006
- Testing
- Dienogest, Propolis
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Endometriosis
IVF Versus Surgery for Endometriosis Related Infertility
The management of endometriosis-related infertility remains controversial. In particular, there is an equipoise for infertile women with endometriotic lesions detected at ultrasound.
- Trial name
- SVIDOE (NCT04743167)
- Testing
- Surgery, IVF
- Where
- 3 sites in Italy
- Volunteers
- 206 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Endometriosis, Deep Infiltrating Endometriosis
Prospective Trial of [18F]AlF-FAPI-74 for PET Imaging of Fibroblast Activation Protein in Patients With Endometriosis
The goal of this clinical trial is to learn whether [18F]AlF-FAPI-74 PET/CT can help detect endometriosis in adult women who are already scheduled for laparoscopy due to suspicion of deep infiltrating endometriosis or superficial…
- Conditions
- Endometriosis, Deep Infiltrating Endometriosis, Women, Superficial Peritoneal Endometriosis
- Trial name
- EM-FAPI (NCT07876648)
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infertility, Endometriosis
The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.
In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy.
- Trial name
- NCT01682642
- Testing
- Zoladex
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Endometriosis; Peritoneum
Is Laparoscopic Excision for Peritoneal Endometriosis Helpful or Harmful?
The trial seeks to test effect of laparoscopic excision of peritoneal endometriosis on pelvic pain. Data will also be gathered on quality of life and neuropathic pain.
- Trial name
- NCT05162794
- Testing
- Laparoscopy with excision, Laparoscopy without excision, Medical treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Endometriosis
Serum and Peritoneal Fluid Bank for Endometriosis Markers
The purpose of this study is to investigate differences in protein expression profiles of blood and peritoneal fluid samples obtained from patients who do, and those who do not, have endometriosis seen during laparoscopic…
- Trial name
- NCT00194233
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Endometriosis, Infertility Unexplained
Endometriosis and Peritoneal Dysbiosis
Endometriosis is a complex clinical syndrome that impairs many aspects of a woman's life, characterized by a chronic estrogen-dependent inflammatory process, mainly affecting the pelvic organs, with ectopic presence of tissue…
- Trial name
- NCT05824819
- Testing
- Next Generation Sequencing (NGS)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Endometriosis
The Immune Base of Endometriosis
Endometriosis is a chronic disabling inflammatory disease which effects 15-20% of women in their reproductive life. In patients suffering from endometriosis retrograded menstrual cells induce an inflammatory…
- Trial name
- NCT00370123
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Endometriosis (Diagnosis), Endometriosis
Combining Ultrasound and Biomarkers to Diagnose Superficial Endometriosis
Endometriosis is a benign gynecological disease characterized by uterine-like cells growing outside the uterus, leading to pain, infertility, and inflammation.
- Trial name
- SPGENDO (NCT05523284)
- Testing
- SonoPODography
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Endometriosis
PGL5001 Proof of Concept Study in Inflammatory Endometriosis
This is a prospective, three-part (Part A1, Part A2 and Part B),Phase II study investigating the efficacy, safety, pharmacokinetics and pharmacodynamics of the JNK inhibitor PGL5001 orally administered for up to 5 months with…
- Trial name
- JADE (NCT01630252)
- Testing
- PGL5001
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- PregLem SA
Endometriosis, Endometriosis-related Pain
Histologic Comparison of Ablative Techniques for Endometriosis
To our knowledge, no other human studies directly compare the effectiveness of the various ablative technologies. We set out to design a study to directly compare ablative energy sources and evaluate their ability to destroy…
- Conditions
- Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic, Endometriosis; Peritoneum
- Trial name
- NCT06414083
- Testing
- Diathermy, CO2 Laser, Argon Beam Coagulator
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- TriHealth Inc.
Endometriosis
Effect of Rosiglitazone on Peritoneal Cytokines in Women With Endometriosis
The purpose of this study is to compare the effect of rosiglitazone versus placebo on soluble proinflammatory markers in peritoneal fluid of women with endometriosis.
- Trial name
- NCT00121953
- Testing
- Rosiglitazone
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometriosis-related Pain, Endometriosis
Pelvic Neuro-Angiogenesis in Deep Endometriosis
Endometriosis is observed in one out of every ten women in society, causing endometrial cells to be found outside their normal location in the body and proliferate in other locations, leading to fibrosis in the tissue due to the…
- Conditions
- Endometriosis-related Pain, Endometriosis, Deep Endometriosis, Endometriosis; Peritoneum
- Trial name
- NCT06286371
- Testing
- Laparoscopic Endometriosis Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Uludag University
Endometriosis
Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier
Endometriosis is a common disease of women in the reproductive age and is an important cause for female infertility. Endometriosis is often associated with the development of adhesions which further compromises the fertility of…
- Trial name
- NCT02165917
- Testing
- Excision plus hyaluronic acid gel, Excision only
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Pius-Hospital Oldenburg
Endometriosis, Laparoscopy
Diagnostic Value of ICG in Endometriosis
This study evaluates the diagnostic value of the addition of indocyanine green and near infrared fluorescence imaging during laparoscopy in patients with suspected endometriosis.
- Conditions
- Endometriosis, Laparoscopy, Near Infrared Fluorescence Imaging, Indocyanine Green (ICG)
- Trial name
- NCT03850158
- Testing
- Indocyanine Green
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary
Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions
Full conditioning of the peritoneal cavity during laparoscopic surgery will decrease post-operative pain, inflammation and adhesion formation.
- Conditions
- Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary, Fibroid/Myoma (Uterus/Cervix)
- Trial name
- NCT01344486
- Testing
- full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Endometriosis, Angiopoietin-like Protein-4
Endometriosis-Angiopoietin-like Protein-4
Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like…
- Conditions
- Endometriosis, Angiopoietin-like Protein-4, Pelvic Pain
- Trial name
- NCT07164196
- Testing
- Angiopoietin-like protein-4 (ANGPTL4) Peritoneal Fluid Level, Cancer Antigen 125 (CA-125) Serum Level, Angiopoietin-like protein-4 (ANGPTL4) Serum Level
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Endometriosis
Evaluation of M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages.
Accumulating evidence suggests that the peritoneal microenvironment of women affected by endometriosis undergoes a number of local inflammatory-reparative phenomena, with the involvement of resident macrophages, and the…
- Trial name
- NCT03136978
- Testing
- Evaluation of M1 and M2 macrophages by flow cytometry.
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Messina
Endometriosis
ICG-Based Fluorescence Imaging for Intra-operative Detection of Endometriosis
Endometriosis is a common disease for which the current gold standard for diagnosis is a diagnostic laparoscopy with histologic confirmation.
- Trial name
- NCT03017989
- Testing
- NIRF imaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Endometriosis
Endometriosis: Immunomodulation
The purpose of this study is to compare the effect of pioglitazone versus no drug on soluble profinflammatory markers in peritoneal fluid of women with endometriosis.
- Trial name
- NCT01184144
- Testing
- Pioglitazone
- Sponsor
- University of Wisconsin, Madison