Clinical trials: Endometriosis
Deep Endometriosis, Chronic Pelvic Pain
Repetitive Transcranial Magnetic Stimulation as an Analgesic Treatment in Endometriosis Chronic Pain : Feasibility
Endometriosis is associated with different types of pain (acute, chronic, excess nociception, neuropathic) generated by different mechanisms in the nervous system.
- Trial name
- ENDOSTIM (NCT03204682)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Endometriosis, Endometriosis of Colon
Intraoperative vs Transvaginal Ultrasound in Rectosigmoid Endometriosis
Deep infiltrating endometriosis (DIE) of the rectum and rectosigmoid colon represents one of the most severe forms of endometriosis and often requires surgical management when symptomatic and unresponsive to medical therapy.
- Conditions
- Endometriosis, Endometriosis of Colon, Endometriosis; Bowel, Endometriosis, Rectum
- Trial name
- INTREND (NCT07517055)
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endometriosis, Pelvic Pain
Endometriosis : Traditional Medicine vs Hormone Therapy
This 36-week study will determine whether traditional Chinese medicine (acupuncture and Chinese herbs) is as effective as hormone therapy for alleviating endometriosis-related pelvic pain.
- Trial name
- NCT00034047
- Testing
- Acupuncture, Chinese Products, Nafarelin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Endometriosis
Follow-up of Treatment Outcome, Quality of Life, Sexual Life and Partnership After Surgery of Endometriosis
Follow-up of treatment outcome, quality of life, sexual life and partnership after surgery of endometriosis by means of a questionnaire 1 year after surgical Intervention.
- Trial name
- NCT03769584
- Testing
- Follow-up questionnaire, Follow- up interview
- Where
- Switzerland
- Volunteers
- 31 people
- Sponsor
- University Hospital, Basel, Switzerland
Endometriosis
A Study to Evaluate Safety and Efficacy of Elagolix in Patients With Moderate to Severe Endometriosis-Associated Pain
This is a Phase 3, multicenter, double-blind, placebo-controlled, randomized study to assess the safety and efficacy of elagolix versus placebo in premenopausal 18 to 49 year old women with moderate to severe…
- Trial name
- NCT05648669
- Testing
- Elagolix
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Endometrioma
Surgicel Reduces Ovarian Endometriomas Recurrence
Two hundred women aged from 20 to 35 years undergoing conservative laparoscopic treatment of ovarian endometriomas (either by drainage or cyst wall excision) were included.
- Trial name
- NCT02947724
- Testing
- SURGICEL®
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endometriosis, Uterine Fibroids
A Phase 1 Clinical Study to Evaluate the Effects of SHR7280 on the Pharmacokinetics of Midazolam, S-warfarin, Omeprazole, Digoxin, and Rosuvastatin in Healthy Subjects
The purpose of this study is to evaluate the effects of SHR7280 on the pharmacokinetics of midazolam, S-warfarin, omeprazole, digoxin and rosuvastatin in healthy subjects.
- Conditions
- Endometriosis, Uterine Fibroids, Assisted Reproduction
- Trial name
- NCT06949124
- Testing
- SHR7280 Tablets
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Visualization of Ureters in Gynecological Surgery, Deep Infiltrative Endometriosis
ICG for Visualization of the Ureters in DIE
Endometriosis is a common condition with an incidence of approximately 10% of all women in the fertile phase. Deep infiltrating endometriosis (DIE) has been shown to be associated with high morbidity.
- Conditions
- Visualization of Ureters in Gynecological Surgery, Deep Infiltrative Endometriosis, ICG (Indocyanine Green), Near Infrared Imaging
- Trial name
- Lavic (NCT05206279)
- Testing
- Ureteral injection of Indocyanine Green Powder (diluted)
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Endometriosis, Endometriosis (Diagnosis)
Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function
Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity.
- Conditions
- Endometriosis, Endometriosis (Diagnosis), Urinary Tract Diseases
- Trial name
- RENDO (NCT07776574)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Endometriosis, Chronic Pain
Perioperative Yoga Therapy and Endometriosis Surgery
YOGENDOCHIR is a multicentre, prospective, randomised, controlled, parallel-group study involving 188 adult women scheduled to undergo surgery for endometriosis.
- Conditions
- Endometriosis, Chronic Pain, Impairment of Quality of Life
- Trial name
- YOGENDOCHIR (NCT07765680)
- Testing
- Standard surgical management for endometriosis, Structured perioperative yogatherapy programme plus standard surgical management
- Where
- 4 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Lille
Endometriosis
Robotic Surgical Management of Endometriosis: Excision Versus Ablation
Patients who are planning to undergo laparoscopic surgery for endometriosis will be assigned to either ablation or excision of endometriosis.
- Trial name
- NCT02350790
- Testing
- Robotic ablation, Robotic excision
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis
Influence of Laparoscopic Endometrioma Stripping Surgery on Serum Anti-mullerian Hormone Levels
To compare changes in follicular ovarian reserve in women before and six months after laparoscopic operation: endometrioma stripping surgery.
- Trial name
- NCT02286076
- Where
- 3 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Centre of Serbia
Endometriosis
Work Ability-Productivity Among Clinical Health Workers Endometriosis Study
A qualitative multicentre study protocol. The prospective research explores clinical health workers with a diagnosis of endometriosis, experiencing regular pain and their perceptions of work ability-productivity.
- Trial name
- Work ACHES (NCT05770843)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Birkbeck, University of London
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Endometriosis Ovary
Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy
Endometriosis is a disease characterized by the presence of endometrial tissue outside the uterus cavity, causing important chronic pain and sterility in those patients suffering from it.
- Trial name
- NCT03826355
- Testing
- CO2 (carbon dioxide) laser vaporisation, Stripping technique
- Volunteers
- 16 people
- Sponsor
- Hospital Clinic of Barcelona
Ovarian Endometrioma
Laparoscopic Ovarian Cystectomy Versus Aspiration and Coagulation in Ovarian Endometrioma
The aim of this study is to evaluate the impact of laparoscopic ovarian cystectomy versus aspiration and coagulation on ovarian reserve and pelvic pain in cases of ovarian endometrioma.
- Trial name
- NCT03615352
- Testing
- ovarian cystectomy, ovarian cyst aspiration and coagulation
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Shaimaa Mostafa Mohammed Refaay El shemy
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Endometriosis, Endometriosis Ovary
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis
Endometriosis is one of the most common infertility-related gynecologic disorder that affect approximately 10-15% of women in reproductive age. The main symptoms are chronic pelvic pain, infertility, dysmenorrhea and dyspareunia.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Rectovaginal Septum
- Trial name
- NCT04401592
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Endometriosis
Relaxin, Matrix Metalloproteinase-2 and Interleukin-6 in Women With Chronic Pelvic Pain
In our study, by evaluating the serum and vaginal-peritoneal fluid levels of Relaxin, Matrix Metalloproteinase-2 and Interleukin-6 in women over 35 years of age with chronic pelvic pain, the investigators aimed to reveal their…
- Trial name
- NCT06628479
- Testing
- interleukin, enzyme, hormone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Endometriosis
Predictive Value of Preoperative Evaluation in Cases of Recurrent Endometriosis
To investigate the effect of preoperative evaluation parameters in predicting recurrent disease in women who have undergone cystectomy or unilateral salpingo-oophorectomy due to endometriosis.
- Trial name
- NCT06132009
- Testing
- Surgery of endometriosis
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bagcilar Training and Research Hospital