Clinical trials: Endonasal Surgery
Pituitary Adenoma
Long-term Follow up for Retinal Vascular Changes After Endoscopic Endonasal Pituitary Surgery.
This study investigates the retinal vascular features, using optical coherence tomography angiography, in patients during one year's follow up after the endoscopic endonasal surgery to remove an intra-suprasellar pituitary…
- Trial name
- NCT04546386
- Testing
- Endoscopic endonasal pituitary surgery
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Paranasal Sinus Diseases, Nasal Diseases
Design of an Augmented Reality System by Integration of CT Scan or MRI Data With Endoscopic Images for Video-assisted Endonasal Endoscopic Surgery
The gold standard surgical treatment for benign nasosinus pathologies is endoscopic surgery. This surgery has experienced considerable growth over the last 30 years.
- Conditions
- Paranasal Sinus Diseases, Nasal Diseases, Lacrimal Apparatus Diseases
- Trial name
- NORA (NCT04968561)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Skull Base Neoplasms, Skull Neoplasms
Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery
This study is being done to demonstrate the feasibility of using a nasal endoscope to perform intraoperative angiography of surgical field, with the goals to evaluate anatomical landmarks and tumor characteristics during skull…
- Conditions
- Skull Base Neoplasms, Skull Neoplasms, Bone Neoplasm, Neoplasms
- Trial name
- ICG2 (NCT03072186)
- Testing
- near-infrared light nasal endoscope used with ICG
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University
Surgery--Complications
Incidence of Rhinological Morbidities During Endonasal Pituitary Surgery, With or Without Nasoseptal Flap
Determine and compare prospectively the incidence of rhinological adverse events during pituitary surgery with or without nasoseptal flap
- Trial name
- HLNS (NCT04493801)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Brest
Acromegaly
A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.
If someone is diagnosed with a pituitary tumor that causes acromegaly (too much growth hormone) the treatment is to have it surgically removed. This study has two phases.
- Trial name
- NCT01861717
- Testing
- lanreotide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Saint John's Cancer Institute
Skull Base Pathology
Olfactory Function Following Endoscopic Endonasal Skull Base Surgery
The purpose of this study is to compare a subject's sense of smell before and after endoscopic endonasal surgery to remove a skull base abnormality (i.e.
- Trial name
- UPSIT (NCT02165969)
- Testing
- endoscopic endonasal surgery with UPSIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ricardo L. Carrau, MD
Pituitary Neoplasm, Pituitary Adenoma
Rhinological Outcomes in Endonasal Pituitary Surgery
This is a prospective, multi-center observational study designed to address patient-reported nasal outcomes in adults undergoing endoscopic and microscopic surgical removal of pituitary tumors.
- Conditions
- Pituitary Neoplasm, Pituitary Adenoma, Prolactinoma, Cushings Disease
- Trial name
- NCT01504399
- Where
- 4 sites in United States
- Volunteers
- 235 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Skull Base, Pituitary
Forces During Skull Base Surgery
This study is designed to measure forces applied using standard surgical instruments at the skull base during resection of skull base lesions.
- Conditions
- Skull Base, Pituitary, Robotics, Endonasal Surgery
- Trial name
- NCT01705821
- Testing
- Use of force sensing surgical curette, Removal of pituitary tumor using modified curette
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University
Cervical Surgery, Endonasal Surgery
Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery
Music therapy is a controlled method of listening to music, utilizing its physiological, psychological, and emotional effects on humans during the treatment of illness or trauma.
- Conditions
- Cervical Surgery, Endonasal Surgery, Otologic Disease, Oropharyngeal Disease
- Trial name
- MUSICORL (NCT06600919)
- Testing
- Preoperative Music Therapy Session
- Where
- Reunion
- Volunteers
- 500 people
- Sponsor
- Clinique Saint-Vincent
Nasolacrimal Duct Obstruction
A Comparison of Endonasal Dacryocystorhinostomy With and Without Silicone Tubes
Aim of study is to investigate whether the use of silicone tubes in endonasal DCR surgery increases the success rate and / or complication rate compared to surgery without tubes.
- Trial name
- NCT00784992
- Testing
- Endonasal dacryocystorhinostomy
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pituitary Adenoma
Evaluation of Early Retinal Vascular Modifications After Endoscopic Endonasal Pituitary Surgery
This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the…
- Trial name
- NCT04425954
- Testing
- Endoscopic Endonasal Pituitary Surgery
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Federico II University
Otorhinolaryngologic Diseases
Randomized Assessment of Devices Used to Prevent Post-operative Hemorrhagic Risk in Endonasal Surgery
This study evaluates the efficiency and the cost of three medical devices and the abstention of the use of specific product for the post-operative haemostasis in endonasal surgery .
- Trial name
- PRHEPOCE (NCT03243344)
- Testing
- Surgiflo, Floseal, Algosteril
- Volunteers
- 571 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
CerebroSpinal Fluid (CSF) Leak
NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery
Postoperative cerebrospinal fluid (CSF) leak is a significant complication of endoscopic endonasal approaches (EEA) to the skull base.
- Trial name
- NoSeal (NCT07216157)
- Testing
- Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant
- Where
- Poland
- Volunteers
- 225 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Empty Nose Syndrome
Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome
This study investigates wether patients with increased trigeminal perception threshold and low expression of TRP channels have more often nasal blockage despite functionally successful nasal surgery (TRP channel = transient…
- Trial name
- NCT02230423
- Testing
- Nasal surgery
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University of Zurich
Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water
The Effect of Cold Water Spray Application on Dry Mouth and Thirst Symptoms and Comfort of Patients After Endonasal Endoscopic Surgery After Admission to Intensive Care Unit
The aim of this observational study was to evaluate the effect of cold water spray application on dry mouth and thirst symptoms and comfort of patients who underwent endonasal endoscopic pituitary surgery in neurosurgery in the…
- Conditions
- Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water, Thirst, Dry Mouth
- Trial name
- NCT06763133
- Testing
- Cold Water Spray Application, Clinical routine practice
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Skull Base
Bed Rest Duration and Outcomes in Endoscopic Skull Base Reconstruction
This study is a randomized controlled trial conducted across multiple centers. Due to the anatomical and pathological complexity of endoscopic endonasal skull base surgery, the study scope was restricted to the midline anterior…
- Trial name
- BRO (NCT07465861)
- Testing
- non-bed-rest, 2-day bed-rest, 1-day bed-rest
- Volunteers
- 316 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Pituitary Tumor
Nasal Packing Following Endoscopic Endonasal Pituitary Resection
There is considerable controversy about the use of nasal packing following endoscopic endonasal resection of pituitary tumors as a necessary treatment amongst Rhinology-Skull Base Surgeons.
- Trial name
- NCT03677713
- Testing
- No nasal packing., Nasal Packing
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Recurrent Nasopharyngeal Carcinoma
Early Recurrent Nasopharyngeal Cancer: the Effect of Surgery vs IMRT
This study is a multicenter RCT to compare 3-year overall survival(OS) rate, progression free survival(PFS),local progression free survival(LPFS),regional progression free survival(RPFS),distant metastasis free survival(DMFS)…
- Trial name
- NCT04215510
- Testing
- endonasal endoscopic surgery, radiation therapy(IMRT)
- Where
- 3 sites in China
- Volunteers
- 286 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Olfaction
A Clinical Trial to Study the Effects on the Olfaction Capacity of an Individual Undergoing Skull Base Surgeries Using Cautery vs Scalpel .
Olfaction is a prominent entity that determines a person's quality of life. During human evolution, olfaction has played an essential role in determining safe food, assessing threats, and developing social relationships.
- Trial name
- NCT07385911
- Testing
- Scalpel, Cautery
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences, Jodhpur
Pituitary Adenoma
Semi-sitting Versus Supine Position in Endoscopic Skull Base Surgery
This study is to prospectively compare the standard supine (control group) and the semi-sitting position (head elevation of 30°; intervention group) in endoscopic endonasal pituitary surgery.
- Trial name
- PosESS (NCT04584866)
- Testing
- Endonasal endoscopic pituitary surgery in semi-sitting position, Endonasal endoscopic pituitary surgery in supine position
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University Hospital, Basel, Switzerland