Clinical trials: Endoscopic Submucosal Dissection (ESD)
Colonic Polyp
Evaluation of a Double Balloon Interventional Platform (DiLumen) for Complex Colonic ESD
The purpose of this randomized study is to compare ESD procedural time and cost facilitated with a dual balloon accessory device versus ESD procedures performed without the accessory device.
- Trial name
- NCT03846609
- Testing
- double balloon interventional platform (DiLumen), no double balloon interventional platform (DiLumen)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Mercy Medical Center
Robot Surgery, Endoscopic Submucosal Dissection (ESD)
Efficacy and Safety of Robot-assisted Endoscopic Submucosal Dissection for Colorectal Neoplasm
The objective of this study is to investigate the role of the flexible auxiliary single-arm transluminal endoscopic robot (FASTER) system in colorectal endoscopic submucosal dissection (ESD) and to validate its superiority over…
- Conditions
- Robot Surgery, Endoscopic Submucosal Dissection (ESD), Colorectal Neoplasms
- Trial name
- NCT06973083
- Testing
- FASTER-assisted ESD, Conventional ESD
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Shandong University
Endoscopic Submucosal Dissection, Levobupivacaine
Local LevoBupivacaine for Pain Relief After Endoscopic Submucosal Dissection for Esophageal Lesions
Endoscopic submucosal dissection (ESD) is commonly performed for (pre)cancerous lesions in the esophagus. Following ESD, post-procedural chest pain is seen in many patients.
- Trial name
- BESD-RCT (NCT06611176)
- Testing
- Local levobupivacaine
- Where
- 3 sites in Netherlands
- Volunteers
- 88 people
- Sponsor
- Laura Boer
GIST
Long Outcome of Endoscopic Submucosal Dissection for Small Gastrointestinal Stromal Tumors (<2cm)
Data are currently insufficient to guide the management of very small gastrointestinal stromal tumors（GISTs）（< 2 cm) discovered incidentally on endoscopy,this study is designed to collect the medical records of patients in…
- Trial name
- NCT03082079
- Testing
- ESD
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)
This single-center, prospective, single-arm study will evaluate whether giving neoadjuvant chemoimmunotherapy can safely shrink esophageal cancer and allow organ-preserving endoscopic removal in selected patients.
- Trial name
- Endosurgery-02 (NCT07317609)
- Testing
- Tislelizumab, Carboplatin, Nab-paclitaxel
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Endoscopic Submucosal Dissection
Multi-center Evaluation of the Clinical Utility of ESD in the Western Population
The aim of this multi-center study is to prospectively document the clinical utility of ESD.
- Trial name
- NCT02989818
- Testing
- Endoscopic Submucosal Dissection
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Florida
Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions.
- Conditions
- Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT07088744
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- 4 sites in China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer, Rectal Polyp
EndoscoPic Submucosal dIssection Using geL Versus glycerOl for Submucosal iNjection
The EPSILON study aims to comparatively evaluate the submucosal injection using ORISETM gel and glycerol during an ESD procedure in a specific population with superficial gastric and rectal (pre)neoplastic lesions.
- Trial name
- EPSILON (NCT04977401)
- Testing
- Endoscopic submucosal dissection, use of Orise Gel as lifting agent for endoscopic submucosal dissection, use of glycerol as lifting agent for endoscopic submucosal dissection
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 32 people
- Sponsor
- Erasme University Hospital
Esophageal Cancer, Esophageal Dysplasia
Comparison of O-type Hybrid Knife and IT Knife in ESD
By combining injection and dissection capability together, O-type Hybrid knife could possibly shorten the endoscopic submucosal dissection procedure for upper gastrointestinal neoplasms.
- Conditions
- Esophageal Cancer, Esophageal Dysplasia, Stomach Cancer, Stomach Dysplasia
- Trial name
- NCT01760070
- Testing
- Hybrid knife, IT knife
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori, Early Gastric Cancer
Helicobacter Pylori Infection Status and Pathological Features for Predicting Gastric Cancer Biological Behavior and Prognosis: A Real-World Observational Study
This multicenter retrospective and prospective real-world observational study will evaluate the relationship of Helicobacter pylori (H.
- Trial name
- NCT07724496
- Testing
- 13C-Urea Breath Test, Serum Helicobacter pylori Antibody Testing, Pathological Assessment of Gastric Tissue
- Where
- 3 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Gastrointestinal Disease, Gastrointestinal Bleeding
Blood Pressure During ESD is Related With the Postoperative Bleeding
Endoscopic submucosal dissection(ESD) is a prominent minimally invasive operation technique for treating early gastrointestinal tumor.
- Trial name
- NCT03070665
- Testing
- Norepinephrine
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Shanghai Zhongshan Hospital
Carcinoma in Situ of Cervical Part of Esophagus
Deeper Intubation Make Effects on Cervical Esophageal ESD
To compare the efficacy and safety of intratracheal deep intubation with traditional intubation in endoscopic submucosal dissection for early esophageal cancer in the cervical esophagus, and to follow up and assess their…
- Trial name
- NCT06420258
- Testing
- Deeper endotracheal intubation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Provincial Hospital
Barretts Esophagus With Dysplasia
Complete Resection of Barrett's Esophagus Harboring Neoplasia With Endoscopic Submucosal Dissection.
Patients with Barrett's esophagus (BE) have a change in the lining of the esophagus. The normal one the lining of the esophagus changes to a lining similar to that of the intestine.
- Trial name
- BESD (NCT05983419)
- Testing
- ESD
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Francisco Baldaque-Silva
Esophageal Stenosis
Intralesional Steroid Injection Versus Oral Prednisolone in Prevention of Esophageal Stricture
Endoscopic resection of superficial esophageal neoplasms is already a reality and presents important advantages when compared to esophagectomy as fewer complications and better quality of life.
- Trial name
- NCT04498260
- Testing
- Local steroid - triamcinolone acetonide, Oral steroid - predonisolone
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Esophageal Neoplasm, Esophageal Polyp
Monopolar and Bipolar in Esophageal ESD
The objective of this study is to prospectively document the efficacy and clinical outcomes of Endoscopic Submucosal Dissection procedure that utilize either a novel Bipolar-Current ESD device or the standard monopolar…
- Conditions
- Esophageal Neoplasm, Esophageal Polyp, Endoscopic Submucosal Dissection, Bipolar Electocautery
- Trial name
- NCT05736705
- Testing
- Endoscopic Submucosal Dissection, Bipolar electrocautery knife
- Where
- United States
- Sponsor
- Baylor College of Medicine
Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Severe Dysplasia
Piecemeal Versus En Bloc Resection of Large Rectal Adenomas
Currently, colonoscopy is the safest way to detect bowel tumors and polyps, since these can be biopsied and removed in one working process.
- Conditions
- Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Severe Dysplasia, Colorectal Adenomatous Polyp, Colorectal Low Grade Intraepithelial Neoplasia
- Trial name
- PERLA (NCT02238938)
- Testing
- en-bloc resection, piecemeal resection
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 110 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Barrett Esophagus
Autologous Cell Sheets Transplantation After ESD in the Esophagus
Healing of mucosal defects after endoscopic mucosal resection in the oesophagus is prone to result in varying degrees of stenosis, especially if the resected area is large and/or circumferential.
- Trial name
- CellSheet2 (NCT02455648)
- Testing
- ESD/EMR plus Cell Sheet, ESD/EMR
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Matthias Löhr
Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma
EMR Versus ESD for Barrett's Neoplasia
Rationale: The optimal technique for removal of visible dysplastic lesions in Barrett's esophagus remains controversial. Endoscopic mucosal resection (EMR) is safe, effective, easy to apply, and has been the most widely used…
- Conditions
- Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma, Esophageal Cancer
- Trial name
- REMOVE-RCT (NCT05276791)
- Testing
- EMR, ESD
- Where
- 6 sites in Netherlands
- Volunteers
- 331 people
- Sponsor
- St. Antonius Hospital
Early Gastric Cancer or Gastric Adenoma
Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time
Gastric cancer remains a major global health burden, ranking fifth in incidence worldwide and disproportionately affecting Asia, with China accounting for a significant share of cases and deaths.
- Trial name
- NCT07401303
- Testing
- ESD
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Superficial Esophageal Cancer
A Study to Evaluate the Esophageal Stenosis Inhibition Effects of CLS2702C/CLS2702D After Endoscopic Submucosal Dissection (ESD) in Patients With Superficial Esophageal Cancer in the Steroid Administration Risk Group
The purpose of this study is to evaluate the efficacy and safety of esophageal epithelial regenerative treatment by the transplantation of the product, CLS2702C, to the esophageal wound site after extensive ESD for superficial…
- Trial name
- NCT04689594
- Testing
- CLS2702C/CLS2702D
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- CellSeed Inc.