Clinical trials: Endothelial Cell Density
Uveitis, Posterior
Corneal Endothelial Cell Density in Eyes Treated With a Fluocinolone Acetonide Intravitreal Implant
An Observational Change-From-Baseline Evaluation of Corneal Endothelial Cell Density in Eyes Treated with a Fluocinolone Acetonide Intravitreal Implant
- Trial name
- NCT03145025
- Testing
- Retisert, Fluocinolone Acetonide Intravitreal Implant
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma, Endothelial Cell Loss, Corneal
Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent Implantation
The objective of this study is to evaluate the change of endothelial cell count after XEN45 in patients with or without cataract operation.
- Trial name
- NCT04547036
- Testing
- XEN45
- Where
- Austria
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Corneal and Endothelial Cell Measurements
Comparative Study of Specular Microscope for Cell Density, Coefficient of Variation, Hexagonality and Corneal Thickness
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Nidek Specular Microscope CEM-530.
- Trial name
- NCT01729975
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Endothelial Cell Density Loss
Study of Endothelial Cell Condition After Cataract Surgery Performed Using Capsulorhexis or ZEPTO
This study will use images of the subjects' corneal endothelium obtained using non-invasive specular microscopy to obtain corneal endothelial cell density, the coefficient of variation in endothelial cell size, and the percentage…
- Trial name
- ZEPTO (NCT04882189)
- Testing
- Imaging
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centricity Vision, Inc.
Corneal Endothelial Cell Loss, Mydriasis
Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco
Study evaluates safety of intracameral injection of Fydrane (tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) on corneal endothelium, and efficiency in maintaining pupillary dilatation during phacoemulsification surgery.
- Conditions
- Corneal Endothelial Cell Loss, Mydriasis, Cataract
- Trial name
- NCT04396301
- Testing
- Fydrane®: (Manufacturer DELPHARM TOURS, FRANCE).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Endothelial Cell Density Loss
Endothelial Changes in Diabetic and Non-diabetic Patients Undergoing Phacoemulsification
The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of…
- Trial name
- NCT07369388
- Testing
- Phacoemulsification
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Endophthalmitis
Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis.
There has thus far been only one randomized and masked clinical trial in the world to evaluate the efficacy of the intraoperative intracameral injection of antibiotics with the objective of preventing endophthalmitis following…
- Trial name
- NCT02770729
- Testing
- Moxifloxacin, No injection of moxifloxacin
- Where
- Brazil
- Volunteers
- 3,640 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Cataract
Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery
This is a study aimed at evaluating the effectiveness and impact of two intraocular irrigating solution (BSS ® versus glucose-bicarbonate-Ringer Lactate - GBRL) on the health of the cornea after cataract surgery by…
- Trial name
- NCT01334658
- Testing
- Phacoemulsification cataract surgery, Glucose-bicarbonate-Ringer Lactate (GBRL), Balanced Salt Solution (BSS®)
- Volunteers
- 64 people
- Sponsor
- Grupo de Estudos em Oftalmologia Clínica e Cirúrgica
Metabolic Syndrome
The High Density Lipoprotein and Endothelial Function, Niacin and Nitric Oxide Study (The High-Ennd Study)
The aim of the present study is to characterize novel mechanisms whereby HDL may exert potent vasculoprotective effects independent of reverse cholesterol transport, in particular the effect of HDL on the regulation of the…
- Trial name
- NCT00346970
- Testing
- Extended-Release Niacin
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Pseudoexfoliation
Corneal Endothelium Evaluation After Phacoemulsification in Diabetec and Non-diabetic Patients With Pseudoexfoliation
Our study is a comparative study, that was conducted to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (IOL) implantation in normal…
- Trial name
- NCT04965168
- Testing
- phacoemulsification of the lens
- Where
- Egypt
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Minia University
Age Related Cataract, Cataract
Effect of Trypan Blue on Corneal Endothelial Cell Count During Phacoemulsification
This randomized controlled trial evaluated the effect of trypan blue on corneal endothelial cell count in patients undergoing phacoemulsification for age-related cataract.
- Trial name
- NCT07735000
- Testing
- Trypan Blue, Phacoemulcification
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Healthy
Corneal Endothelial Cell Density Changes In Healthy Subjects, When Administered ISV-403 for 5 Days
The objective of this study is to evaluate the effect on corneal endothelial cell density changes when ISV-403 is administered for five (5) days compared to no drug treatment, in healthy subjects.
- Trial name
- NCT01120418
- Testing
- Besifloxacin Ophthalmic Suspension 0.6%
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Pterygium
Pterygium Head Body MMC1: Two Different Surgical Procedures and Their Effect on Endothelial Cell Count.
To evaluate changes in endothelial cell count after pterygium surgery with mitomycin C (MMC) 0.02%
- Trial name
- PHB-MMC1 (NCT02641132)
- Testing
- Mitomycin C 0.02%, Pterygium surgery
- Where
- 2 sites in Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Cataract
BSSPlus Versus Lactated Ringer's for Phacoemulsification
Two intraocular irrigating solutions (BSSPlus versus Lactated Ringer's) are compared in this prospective, randomized, masked trial to investigate for differences in preservation of corneal integrity after phacoemulsification…
- Trial name
- NCT00801359
- Testing
- Phacoemulsification, BSSPlus solution, Lactated Ringer's solution
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Cataract
Aqualase Versus Torsional ip. A Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity
Objective of this study is the comparative assessment of the impact of torsional and liquefaction technologies on endothelial cells (ECC), corneal edema (CCT) and corneal sensitivity (CCS) in a sample of cataract patients.
- Trial name
- NCT01480557
- Testing
- liquefaction, Torsional ip
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- Democritus University of Thrace
Corneal Endothelial Cell Changes
Corneal Endothelial Cell Density Changes, When Mapracorat Ophthalmic Suspension 3%, is Administered for 14 Days
The objective of this study is to evaluate the effect on corneal endothelial cell density (cells/mm²) changes at 3 months when mapracorat ophthalmic suspension, 3% is administered QID (four times daily), for 14 days in healthy…
- Trial name
- NCT01736462
- Testing
- Mapracorat
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Endothelial Corneal Dystrophy
Predictive Factors of Good Results After Primary Descemet's Membrane Endothelial Keratoplasty (DMEK)
Aim: Identify predictive factors of good results after primary Descemet's Membrane Endothelial Keratoplasty (DMEK) in Fuchs Endothelial Corneal Dystrophy (FECD).
- Trial name
- GOODRMEK (NCT04469933)
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Amount of Corneal Flattening (Kmax Flattening), Change in the Endothelial Cell Count
Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management
The objective of this study is to compare the clinical effectiveness and safety of Topo-Pachymetric Customized Accelerated Epithelium-On (aCFXL) to Standard Accelerated Epithelium-Off (aCXL) Corneal Collagen Cross-Linking in the…
- Trial name
- NCT06549387
- Testing
- Corneal cross linking
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Glaucoma
Evaluation of the Impact of the XEN® Implant on Endothelial Cell Density, 3 Years After Surgery
Glaucoma is a blinding optic neuropathy affecting 80 million people worldwide, with primary open-angle glaucoma being the most common etiology.
- Trial name
- RETROXEN (NCT05904613)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Corneal Endothelial Cell Loss, Ozone Therapy
Effect of Systemic Ozone Therapy on Corneal Endothelium
This study evaluates the safety of systemic ozone therapy on the corneal endothelium, a vital non-renewable tissue that maintains corneal transparency.
- Trial name
- OZON-CORNEA (NCT07718100)
- Testing
- Systemic Ozone Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University