Clinical trials: Endothelial Progenitor Cells
Myocardial Reperfusion Injury, Treatment Outcome
Clinical Efficacy of Extracorporeal Cardiac Shock Wave Therapy in Patients With Ischemia-reperfusion Injury
This trial was a prospective, open-label, single-center, randomized trial, To observe the clinical efficacy of extracorporeal cardiac shock wave in the treatment of patients with myocardial ischemia-reperfusion injury and the…
- Conditions
- Myocardial Reperfusion Injury, Treatment Outcome, Prognosis, ST Elevation Myocardial Infarction
- Trial name
- CEECSWIRI (NCT05624203)
- Testing
- Extracorporeal cardiac shock wave therapy(ECSW)
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Coronary Restenosis
EGO-COMBO Clinical End-point Extension Study Beyond 36 Months
In this study, the safety and efficacy of COMBO TM stent beyond 36 months are assessed, in particular the occurrence of late stent thrombosis and late loss catch-up (restenosis).
- Trial name
- NCT02263313
- Testing
- EGO-COMBO group
- Where
- China
- Volunteers
- 59 people
- Sponsor
- The University of Hong Kong
Systemic Lupus Erythematosus
Ramipril, Endothelial Function and Endothelial Progenitor Cells in Patients With Systemic Lupus Erythematosus
The aim of this study was to evaluate the effect of ramipril on the endothelial function and on the number of endothelial progenitor cells (EPCs) in systemic lupus erythematosus (SLE) patients.
- Trial name
- NCT03979976
- Testing
- Ramipril
- Where
- Brazil
- Volunteers
- 37 people
- Sponsor
- Federal University of São Paulo
Acute Coronary Syndrome (ACS)
EndoTic - Endothelium and Ticagrelor
Randomized clinical trial to assess the influence of treatment with ticagrelor or clopidogrel in the number of CECs (Circulating Endothelial Cells) and EPCs (Endothelial Progenitor Cells) in patients with ACS (Acute Coronary…
- Trial name
- NCT02244710
- Testing
- Ticagrelor vs Clopidogrel
- Where
- 3 sites in Spain
- Volunteers
- 109 people
- Sponsor
- Fundación Investigación Sanitaria en León
Type 2 Diabetes, Endothelial Dysfunction
Endothelial Effects of Basal Insulin: Detemir Versus Glargine
Endothelial progenitor cell (EPC) level represents a surrogate marker of cardiovascular risk and an indicator of the ongoing vascular damage.
- Conditions
- Type 2 Diabetes, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT00699686
- Testing
- Glargine, Detemir
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Aging, Exercise
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health.
- Conditions
- Aging, Exercise, Cardiovascular Disease
- Trial name
- EPC-Ex (NCT01169831)
- Testing
- Exercise Training, Exercise Cessation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Vascular Formation
Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force
This study will evaluate the effects of NHLBI's employee exercise program, Keep the Beat, on blood vessel function. Damage to blood vessels can cause narrowing of the vessels, resulting in reduced blood flow to parts of the body…
- Trial name
- NCT00246883
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Prospective Registry to Asses the Long-term Safety and Performance of the Combo Stent
Patients with stenosis in one or more coronary artery are often treated with a percutaneous coronary intervention (PCI). As part of the PCI treatment a stent is often placed to keep the vessel open over time.
- Trial name
- REMEDEE Reg (NCT01874002)
- Testing
- Combo stent
- Where
- 9 sites in Latvia, Luxembourg and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Robbert J de Winter
Atherosclerotic Disease
Telomeres and Arterial Aging
The prevailing view in telomere epidemiology is that leukocyte telomere length (LTL) is associated with atherosclerosis and accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative…
- Trial name
- TELARTA (NCT02176941)
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Central Hospital, Nancy, France
Metabolic Syndrome
The High Density Lipoprotein and Endothelial Function, Niacin and Nitric Oxide Study (The High-Ennd Study)
The aim of the present study is to characterize novel mechanisms whereby HDL may exert potent vasculoprotective effects independent of reverse cholesterol transport, in particular the effect of HDL on the regulation of the…
- Trial name
- NCT00346970
- Testing
- Extended-Release Niacin
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Healthy
Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers
We plan to investigate the acute effects of inhaling e-cigarette vapor on cell function measured by microvesicles and endothelial progenitor cells.
- Trial name
- ESMOKE (NCT02532894)
- Testing
- Electronic cigarette
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy
CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men
The original purpose of this research study was to understand the effects of testosterone (T) and estrogen on stem cells in the blood.
- Trial name
- CEP-1 (NCT00729859)
- Testing
- Acyline, Acyline + Testosterone gel, Acyline + testosterone gel + anastrozole
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Washington
The Apparatus for Processing the Tubular Graft Modification Will be Designed and Evaluated., The On-site Capturing of the Endothelial (Progenitor) Cells by Peptide-mediated Selective Adhesion in Vitro and in Vivo Will Also be Elucidated.
Endothelialized ePTFE Graft by Nanobiotechnology
The replacement of autologous blood vessels by artificial grafts is urgently needed in clinical applications. Expanded polytetrafluoroethylene (ePTFE) grafts are the most clinically used artificial blood vessels because of its…
- Conditions
- The Apparatus for Processing the Tubular Graft Modification Will be Designed and Evaluated., The On-site Capturing of the Endothelial (Progenitor) Cells by Peptide-mediated Selective Adhesion in Vitro and in Vivo Will Also be Elucidated., The Patency Rate of ITRI-made Artificial Blood Vessels Will be Evaluated by the Porcine Animal Model.
- Trial name
- NCT02002104
- Where
- Taiwan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
End Stage Liver Disease
Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis
This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis.
- Trial name
- NCT03109236
- Testing
- GCSF, CD133 Cells Transplantation
- Where
- Singapore
- Volunteers
- 66 people
- Sponsor
- National University Hospital, Singapore
Hypertrophic Obstructive Cardiomyopathy
Mobilization of Endothelial Progenitor Cells and Aspirin
Aspirin at doses used during acute myocardial infarction may inhibit the mobilization of endothelial progenitor cells (EPCs).
- Trial name
- TROPHIC 3 (NCT02674958)
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Glioblastoma, Glioma
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness
Tumors of the central nervous system affect 21 people per 100,000 every year, a figure that refers to countries with advanced economies, with an increase in incidence over time.
- Conditions
- Glioblastoma, Glioma, Glioma Glioblastoma Multiforme
- Trial name
- NCT06348693
- Testing
- cell isolation from tumor biopsies and biomarker investigation
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Immunosuppression, Renal Failure
The Vienna Prograf and Endothelial Progenitor Cell Extension Study
Conversion of renal transplant recipients from either tacrolimus or cyclosporin A to tacrolimus modified release to investigate the effects of the MDR1/CYP450 genotype on the trough blood levels of tacrolimus with modified…
- Trial name
- PEP-X (NCT03751332)
- Testing
- Tacrolimus
- Volunteers
- 87 people
- Sponsor
- Medical University of Vienna
Type 2 Diabetes Mellitus
Study About Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients
In this study, the investigators aim to investigate whether saxagliptin modulate endothelial progenitor cells number and flow-mediated dilation in newly diagnosed, treatment-naive type 2 diabetic patients.
- Trial name
- NCT02920801
- Testing
- saxagliptin, Metformin
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells
The objectives of the study are to test the hypothesis that external counter pulsation therapy (ECPT) provides clinical benefit by improving the number and function of endothelial progenitor cells (EPCs) in peripheral blood of…
- Trial name
- NCT00272571
- Testing
- External counter pulsation therapy
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)