Clinical trials: Endotoxin Levels
TNF-alfa, Endotoxin Levels
Vitamin A and Response to Endotoxin
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models.
- Trial name
- NCT00168649
- Testing
- Vitamin A
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Chronic Kidney Disease
Vitamin D Repletion in Chronic Kidney Disease
The reason for doing this research is that people with kidney disease often suffer from heart disease. Why this happens is not fully known.
- Trial name
- NCT00772772
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Pulp Necrosis, Apical Periodontitis
Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic…
- Trial name
- NCT07897591
- Testing
- Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Retina, Regional Blood Flow
Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
Oxidative stress, which refers to cellular damage caused by reactive oxygen intermediates, has been implicated in many disease processes, especially age-related disorders.
- Conditions
- Retina, Regional Blood Flow, Endotoxin, Escherichia Coli
- Trial name
- NCT00431691
- Testing
- vitamin and mineral supplement, Escherichia coli Endotoxin (LPS), 100% O2
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
End Stage Renal Disease
The Effect of Probiotic Supplementation
This is a double-blind randomised controlled trial where participants will be randomised to either twice daily 65ml of Lactobacillus casei Shirota for six months or a matched placebo.
- Trial name
- NCT04390347
- Testing
- Yakult
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Bloodstream Infection
Procalcitonin and Endotoxin Sequential Levels to Optimize the Treatment of Bloodstream Infections
Bloodstream infections (BSI) are a major cause of morbidity and mortality. Bloodstream infections are also costly and result in prolonged hospital stays.
- Trial name
- NCT00870623
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Nebraska
Necrotic Pulp
Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth
The aim of this prospective in vivo randomized clinical trial to evaluate influence of combination of calcium Hydroxide (CALCIPAST Paste, Poland) and chlorhexidine Gel 2% (Gluco-Chex 2%, Cerkamed, Poland) in comparison to calcium…
- Trial name
- NCT03009006
- Testing
- Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting, Calcium Hydroxide Paste - Non-Setting
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Leaky Gut Syndrome
Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
- Trial name
- NCT01088087
- Testing
- colostrum
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Endotoxemia, Peripheral Arterial Disease
Elevated Levels of Antibodies to Endotoxin Core in Hemodialysis Patients With Peripheral Artery Disease
Background Peripheral arterial disease (PAD) and its relevant complications are more common in hemodialysis (HD) patients. The potential association regarding chronic kidney disease dysbiosis, inflammation and metabolic…
- Trial name
- NCT05752968
- Where
- Taiwan
- Volunteers
- 155 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Hemoperfusion, Sepsis
EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients
Sepsis and septic shock are life-threatening conditions in which the body's response to infection can cause dangerously low blood pressure and organ failure.
- Conditions
- Hemoperfusion, Sepsis, ICU, Endotoxin Levels
- Trial name
- NCT07788144
- Testing
- Adsorptive Hemofilter for Continuous Renal Replacement Therapy, Polymyxin B-Immobilized Hemoperfusion Cartridge
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyoung Moo Im
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Preoperative Cardiac Surgery Patients
The Effect of Prophylactic Pre Operative Probiotic Therapy on Endotoxin Levels in Cardiac Surgery Patients
The primary hypothesis for the study is that pre-operative prophylactic probiotic Lactobacilli tablets will reduce the severity and incidence of endotoxin rise in post cardiopulmonary bypass in cardiac surgery patients.
- Trial name
- NCT00256022
- Testing
- Lactobacillus Probiotic, Lactose Powder
- Sponsor
- Melbourne Health
Fatigue, End Stage Renal Disease (ESRD)
Lipid Infusion in Dialysis Patients With Endotoxemia
The purpose of this study is to determine whether a phospholipid emulsion is effective in the treatment of chronic endotoxemia in hemodialysis patients.
- Trial name
- LIPIDOSE (NCT00506454)
- Testing
- Lipidose
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Sepsicure
Liver Cirrhosis, Coagulation Disorder
Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes
Rifaximin is an antibiotic that acts locally in the gastrointestinal tract with a broad spectrum of antibacterial activity. The efficacy of rifaximin is well documented in the prevention of acute hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Coagulation Disorder, Platelet Disorder, Endotoxemia
- Trial name
- NCT06630572
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Sepsis
Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation
SRT2379 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice.
- Trial name
- NCT01416376
- Testing
- SRT2379
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sirtris, a GSK Company
Diabetes Mellitus Type 2
Study to Explore the Effects of Probiotics on Endotoxin Levels in Type 2 Diabetes Mellitus Patients
Probiotics, which are believed to be health promoting live microorganisms, have been reported to influence circulating endotoxin levels.
- Trial name
- NCT01765517
- Testing
- Probiotics
- Where
- Saudi Arabia
- Volunteers
- 83 people
- Sponsor
- King Saud University